Navigation Links
Study finds cause of mysterious food allergy, suggests new treatment strategy
Date:7/13/2014

New research in Nature Genetics identifies a novel genetic and molecular pathway in the esophagus that causes eosinophillic esophagitis (EoE), opening up potential new therapeutic strategies for an enigmatic and hard-to-treat food allergy.

EoE is a chronic inflammatory disorder of the esophagus. The condition is triggered by allergic hypersensitivity to certain foods and an over-accumulation in the esophagus of white blood cells called eosinophils (part of the body's immune system). EoE can cause a variety of gastrointestinal complaints including reflux-like symptoms, vomiting, difficulty swallowing, tissue scarring, fibrosis, the formation of strictures and other medical complications.

Reporting their results online, the multi-institutional team of researchers was led by scientists at Cincinnati Children's Hospital Medical Center. The authors identified a molecular pathway specific to epithelial tissue in the esophagus involving a gene called CAPN14, which they found becomes dramatically up-regulated in the disease process.

Epithelial cells help form the membrane of the esophagus. The scientists report that when these cells were exposed to a well-known molecular activator of EoE an immune hormone called Interleukin 13 (IL-13) it caused dramatic up-regulation of CAPN14. The researchers said this happened in what they described as an epigenetic hotspot for EoE on the cells' chromosomes.

CAPN14 encodes an enzyme in the esophagus that is part of the disease process called calpain14, according to Marc E. Rothenberg, MD, senior investigator on the study and director of the Center for Eosinophilic Disorders at Cincinnati Children's. Because caplain14 can be targeted and inhibited by drugs, the study opens up new therapeutic strategies for researchers.

"In a nutshell, we have used cutting edge genomic analysis of patient DNA as well as gene and protein analysis to explain why people develop EoE," Rothenber
'/>"/>

Contact: Jim Feuer
jim.feuer@cchmc.org
513-636-4656
Cincinnati Children's Hospital Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Study Suggests Vaccine May Help Kids With Brain Cancer
2. Study reveals how cancer drug causes diabetic-like state
3. Coffee Drinking in Pregnancy Wont Lead to Sleepless Baby: Study
4. Lower GI problems plague many with rheumatoid arthritis, Mayo Clinic study finds
5. Veggies Like Broccoli, Cabbage May Help Fight Breast Cancer: Study
6. No Added Cancer Risk From Hip Replacement Materials: Study
7. Reported Decline in U.S. Pneumonia Deaths May Be False: Study
8. Early Study Finds Some Promise for Lung Cancer Vaccine
9. Narcissists Often Ace Job Interviews, Study Finds
10. Sexual objectification of female artists in music videos exists regardless of race, MU study finds
11. Soy may alleviate hot flashes in menopause, large-scale study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... 2015 Blue Cross and Blue Shield of ... what it means to “Live Fearless.” , The ... share their stories about how they or someone they know ... by living in the moment. By telling these types of ...
(Date:1/22/2015)... York (PRWEB) January 22, 2015 Thousand ... Fresenius Medical Care recalled its GranuFlo and NaturaLyte dialysis ... litigation underway in U.S. District Court, District of Massachusetts, ... January 20th, the Court has remanded a case filed ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 A ... Sports Medicine flagship journal Medicine & Science in ... before exercise may help reduce gastrointestinal (GI) problems ... , Participants in the double-blind, placebo-controlled study ...
(Date:1/22/2015)... Payday lending practices in four southern ... financial distress to the states that permit them, according ... Center on Race and Wealth. , While they generate ... loans at the same time substantially depress economic activity, ...
(Date:1/22/2015)... Lower-Auto-Insurance.com has released a new blog post explaining the importance of ... the costs of an auto insurance policy . , Clients ... prices for their vehicle insurance policies. The safety a vehicle offers ... Because of this, drivers should always carry a first aid ...
Breaking Medicine News(10 mins):Health News:Blue Cross and Blue Shield of Minnesota to Showcase “Faces of Fearless” 2Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 2Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 3Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 4Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 2Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 3Health News:Howard University Spotlights the Economic Impact of Payday Lending in Southern States 2Health News:Driving Safe And Other Factors That Make Auto Insurance Affordable! 2
... lead to better detection and treatment , , SATURDAY, April ... certain pancreatic cancers might offer hope for treatment of ... of human pancreatic cancers looked at by Johns Hopkins ... receptor (pEGFR), which previous studies had noted as being ...
... solution enhancements will help organizations reduce overtime. , ... ... Atlas Business Solutions, Inc. (ABS), a leading provider of employee ... ScheduleAnywhere®, the affordable and easy-to-use online employee scheduling solution. The ...
... for children, families and future teachersDEARBORN, Mich., April 17 ... Families (CEF) and the University of Michigan-Dearborn,s ... of their new shared facility with a fun night ... Road Crew. Mike Galante, AM Radio Disney Local ...
... net and save a life , ... Washington, D.C. (Vocus) April 17, 2009 -- "I ... leading killer of children and refugees in Africa., , , , ,"Now, I ... Nothing But Nets. How does 100,000 people sound? , , ,"One of the ...
... Failing to list mental disorders makes prevention more difficult, ... About half of those who commit suicide have been ... than 10 percent of their death certificates list mental ... , Incomplete death certificates make it more difficult for ...
... In current economic climate, where people are watching their ... 20 percent off retail pricesWARRENSVILLE HEIGHTS, Ohio, April 17 ... launched a program to help provide its residents with ... The city is making free prescription drug discount ...
Cached Medicine News:Health News:Research Takes Aim at Pancreatic Cancer 2Health News:ScheduleAnywhere.com Gives Managers New Tools to Create Employee Schedules and Reduce Overtime 2Health News:ScheduleAnywhere.com Gives Managers New Tools to Create Employee Schedules and Reduce Overtime 3Health News:Oakwood Healthcare and UM-Dearborn Welcome the Community to Their New Dearborn Facility 2Health News:Oakwood Healthcare and UM-Dearborn Welcome the Community to Their New Dearborn Facility 3Health News:UN Foundation Chairman Ted Turner Thanks Ashton Kutcher, CNN and Others for Raising Awareness About Malaria on Twitter 2Health News:Death Certificates Incomplete for Suicide Victims 2Health News:City of Warrensville Heights Residents Have Access to Easy-to-Use Prescription Drug Discount Card Launched Today 2
(Date:1/23/2015)... FORT MYERS, Fla. , Jan. 23, 2015  Today ... approval of Novartis, Bexsero® for the prevention of ... to 25. Bexsero and Pfizer,s vaccine Trumenba®, which received ... in helping prevent this devastating disease. ...
(Date:1/23/2015)... , Jan. 23, 2015  The Partnership to Fight Chronic Disease ... health care leaders and a new study analyzing the impact ... PFCD is a nationwide coalition working to educate policy makers and ... at the Capitol was focused on how the Iowa ...
(Date:1/23/2015)... , Jan. 23, 2015 More than a third ... quarter of those with private insurance, filled a prescription for ... a report in this week,s Morbidity and Mortality Weekly Report ... care providers to treat moderate to severe pain.  They are ...
Breaking Medicine Technology:The National Meningitis Association (NMA) Applauds FDA Approval of Second Vaccine To Protect Against Serogroup B Meningococcal Disease 2New research shows Iowa health exchange would benefit from improvements 2New research shows Iowa health exchange would benefit from improvements 3Opioid painkillers widely prescribed among reproductive age women 2Opioid painkillers widely prescribed among reproductive age women 3
... authorization for prescription medications is a time-consuming process for ... faxes and hard-copy request forms. While some on-line solutions ... solution and one that is integrated with available e-prescribing ... in the marketplace, CVS Caremark (NYSE: CVS ...
... SHENZHEN, China, May 16, 2011 /PRNewswire-Asia/ -- Global ... or the "Company"), a China-based leading vertically integrated ... and herbal cultivation businesses through its subsidiaries in ... its unaudited financial results for the first quarter ...
Cached Medicine Technology:CVS Caremark to Pilot Electronic Prior Authorization to Help Speed Patient Access to Prescription Medication 2CVS Caremark to Pilot Electronic Prior Authorization to Help Speed Patient Access to Prescription Medication 3Global Pharm Holdings Group Announces First Quarter 2011 Financial Results 2Global Pharm Holdings Group Announces First Quarter 2011 Financial Results 3Global Pharm Holdings Group Announces First Quarter 2011 Financial Results 4Global Pharm Holdings Group Announces First Quarter 2011 Financial Results 5Global Pharm Holdings Group Announces First Quarter 2011 Financial Results 6Global Pharm Holdings Group Announces First Quarter 2011 Financial Results 7Global Pharm Holdings Group Announces First Quarter 2011 Financial Results 8Global Pharm Holdings Group Announces First Quarter 2011 Financial Results 9Global Pharm Holdings Group Announces First Quarter 2011 Financial Results 10Global Pharm Holdings Group Announces First Quarter 2011 Financial Results 11
... Cadwells stainless steel ring electrodes feature ... and an adjustable slider that moves ... motion. Cadwell rings also feature ultraflexible, ... and the wear resistance of bend-relief ...
... The Patient Pak contains these ... bars (can be separated into ... two grounds. Single patient use ... wires (one twisted red and ...
... is an easy-to-use, automated system that enables ... assays for managing hemostatic disordersincluding D-Dimer, Von ... offers reflex and rerun testing for greater ... by our high-quality service to help your ...
... The RX ACCUNET Embolic Protection System is ... easy filter control when performing carotid stenting ... wire based filter system that utilizes rapid ... easily control the filter during catheter manipulations. ...
Medicine Products: