Navigation Links
Study finds biological clue in brain tumor development
Date:3/18/2009

Scientists at The University of Nottingham have uncovered a vital new biological clue that could lead to more effective treatments for a children's brain tumour that currently kills more than 60 per cent of young sufferers.

Clinician scientists at the University's Children's Brain Tumour Research Centre, working on behalf of the Children's Cancer and Leukaemia Group (CCLG), have studied the role of the WNT biological pathway in central nervous system primitive neuroectodermal tumours (CNS PNET), a type of brain tumour that predominantly occurs in children and presently has a very poor prognosis.

In a paper published in the British Journal of Cancer, they have shown that in over one-third of cases, the pathway is 'activated', suggesting that it plays a role in tumour development. The research also highlighted a link between WNT pathway activation and patient survival patients who had a CNS PNET tumour that was activated survived for longer than those without pathway activation.

The reason for the link between WNT pathway activation and better patient prognosis is as yet unclear. It could be that these tumours represent a less aggressive subset or that pathway activation itself actually harms the tumour. However, the pathway could represent an important new target for the treatment of more effective drugs, with fewer side effects.

Senior author Professor Richard Grundy, from the Children's Brain Tumour Research Centre, said: "The principal aim of our research is to reduce the morbidity and mortality of children with central nervous system tumours through improved understanding of tumour biology. Following on from this, we need to translate this knowledge into effective new treatments for brain tumours through the development and assessment of accurately targeted treatments that will cause fewer side effects than conventional chemotherapy or radiotherapy and be more effective. The ultimate aim is to develop 'drugs' that
'/>"/>

Contact: Emma Thorne
emma.thorne@nottingham.ac.uk
44-115-951-5793
University of Nottingham
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Penn study finds pro-death proteins required to regulate healthy immune function
2. New study shows promise in reducing surgical risks associated with surgical bleeding
3. Study, meta-analysis examine factors associated with death from heatstroke
4. Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinsons symptoms
5. Study says COPD testing is not measuring up
6. Preclinical study suggests organ-transplant drug may aid in lupus fight
7. Ability to cope with stress can increase good cholesterol in older white men, study finds
8. High alcohol consumption increases stroke risk, Tulane study says
9. Mailman School of Public Health study examines link between racial discrimination and substance use
10. Pitt study finds inequality in tobacco advertising
11. Stanford study highlights cost-effective method of lowering heart disease risks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/4/2015)... 04, 2015 The New Mel Brooks ... music, will be performed by the award-winning Drama Department ... this March 6-22, 2015, on Fridays, Saturdays and Sundays. ... High School (27118 Silver Spur Road, Rolling Hills ... the program or may be purchased on-line at ...
(Date:3/4/2015)... CA (PRWEB) March 04, 2015 The ... launch of their new L-Style Revolution™ Program. The customized ... men and women of all health and fitness levels ... maintenance goals faster than traditional methods. , “We’re really ... available customized plans based on award winning techniques to ...
(Date:3/4/2015)... 2015 Organic Valley, the nation’s largest cooperative ... its cause campaign to Save the Bros, http://savethebros.com/ ... a difference to Bros everywhere. To date, the video ... The video was named Adweek’s best commercial of the ... and Digiday, among other media outlets. , “We are ...
(Date:3/4/2015)... 04, 2015 The report covers ... survey, marketing channels, industry development trend and proposals. ... industry, including spices definitions, applications and industry chain ... analysis are provided with a focus on history, ... A comparison between the international and Chinese situation ...
(Date:3/4/2015)... March 04, 2015 RapidScale, a global ... Las Vegas, Nevada, on March 16th-18th. They are hosting ... have some of its top engineering executives in attendance ... the RapidScale solution set. Attendees include William Hiatt, CTO; ... Engineer; and Ryan Turpin, Cloud Support Manager. , ...
Breaking Medicine News(10 mins):Health News:The New Mel Brooks Musical Young Frankenstein Performance March 6-March 22, 2015, by the Award Winning Drama Department at Peninsula High School, Rolling Hills 2Health News:The Makers of Liporidex, The Popular Sports Nutrition Supplement Brand, Launches Its New L-Style Revolution™ Diet & Exercise Program That Promises Turbo Charged Results 2Health News:ORGANIC VALLEY URGES PUBLIC TO SAVE THE BROs: CAMPAIGN EARNS MORE THAN 1M VIEWS ON YOUTUBE 2Health News:ORGANIC VALLEY URGES PUBLIC TO SAVE THE BROs: CAMPAIGN EARNS MORE THAN 1M VIEWS ON YOUTUBE 3Health News:World Spices Market Overview & Development 2015-2020 Now Available at DeepResearchReports.com 2Health News:World Spices Market Overview & Development 2015-2020 Now Available at DeepResearchReports.com 3Health News:Rapidscale to Host First Cloudtalk Events at Channel Partners in Las Vegas 2Health News:Rapidscale to Host First Cloudtalk Events at Channel Partners in Las Vegas 3
... Mich., April 1, 2008 ,The Institute for Health ... Health Workplace Center for employers with,founding sponsor HealthMedia, ... demonstrable outcomes. Employers are now paying,attention to this ... -- Behavioral health conditions account for nearly 8% ...
... Researchers Studying New Way to Rehabilitate Stroke Patients, ... people who experience a stroke each year, many never ... their stroke. But physical,therapists, using a specialized treadmill, have ... -- correctly., The results of their study, conducted ...
... ... Named, FRANKLIN LAKES, N.J., April 1, 2008 At the annual,National ... Anthony Welters, Dr. June E. Osborn and Dr. Nelson L. Adams,were the ... Award, respectively., The event was held at the Union League Club ...
... Global,marketing information firm J.D. Power and Associates, ... 40th anniversary today, marking,four decades of fulfilling the ... integrating the voice of the customer into business ... http://www.newscom.com/cgi-bin/prnh/20050527/LAF028LOGO-a ), In 1968, Power established ...
... 1, 2008 Rap music has gone from an art ... to one that often glorifies illegal drug use, according to ... nearly two decades. The study is published in the ... reviewed scientific journal., Positive portrayals of drug use have increased ...
... good patient care , , MONDAY, March 31 (HealthDay News) ... concept of national health insurance, which represents a shift ... survey finds. , Typically, national health insurance plans ... guarantees health coverage for everyone. In most cases, these ...
Cached Medicine News:Health News:IHPM and HealthMedia Announce Industry's First Behavioral Health Workplace Center for Employers 2Health News:IHPM and HealthMedia Announce Industry's First Behavioral Health Workplace Center for Employers 3Health News:Stroke Patients Re-Learn to Walk Correctly Again Using Special Treadmill 2Health News:The Changing Face of Medicine: National Medical Fellowships Annual Awards Gala Honors Three Fellows 2Health News:The Changing Face of Medicine: National Medical Fellowships Annual Awards Gala Honors Three Fellows 3Health News:J.D. Power and Associates Celebrates 40th Anniversary of Representing the Voice of the Customer 2Health News:J.D. Power and Associates Celebrates 40th Anniversary of Representing the Voice of the Customer 3Health News:J.D. Power and Associates Celebrates 40th Anniversary of Representing the Voice of the Customer 4Health News:J.D. Power and Associates Celebrates 40th Anniversary of Representing the Voice of the Customer 5Health News:Drug use increasingly glamorized in rap music, according to new study of 2-decade trends 2Health News:Drug use increasingly glamorized in rap music, according to new study of 2-decade trends 3Health News:Majority of U.S. Doctors Back National Insurance Plan 2
(Date:3/4/2015)... 4, 2015   Mayo Clinic and ... the next generation of wearable biosensors designed to fight ... this technology will be game-changer. These patch biosensors may ... James Levine, M.D., Ph.D. , a Mayo Clinic ... and can be integrated into the care people receive." ...
(Date:3/4/2015)... Kan. , March 4, 2015   Aratana ... pet therapeutics company focused on the licensing, development and ... announced that it will present at the Barclays ... 2015, at the Loews Miami Beach Hotel in ... Steven St. Peter , M.D., President and Chief Executive ...
(Date:3/4/2015)... , March 4, 2015 From March ... the 2015 Distribution Management Conference and Expo in ... is HDMA,s largest supply chain education event, attended ... parties who keep the pharmaceutical distribution industry moving. ... regulatory and legislative issues important to healthcare distribution ...
Breaking Medicine Technology:Mayo Clinic and Gentag, Inc. Announce Agreement To Develop Wireless Sensors for Treatment of Obesity and Diabetes 2Mayo Clinic and Gentag, Inc. Announce Agreement To Develop Wireless Sensors for Treatment of Obesity and Diabetes 3Aratana Therapeutics to Present at the Barclays Global Healthcare Conference 2
... Georgia , May 20, 2010 , ... - Critical Care Pharmacology Course Promotes Patient ... ... than 1,300 healthcare organizations,has partnered with the American Association of Critical-Care Nurses (AACN) ...
... Colo. , May 19 Heska Corporation (Nasdaq: HSKA ) ... announced today the first installations of the Company,s new Vital Path™ Blood ... , , ... , , ...
Cached Medicine Technology:Elsevier/MC Strategies Partners with American Association of Critical-Care Nurses to Launch Interactive, Online Pharmacology Course 2Elsevier/MC Strategies Partners with American Association of Critical-Care Nurses to Launch Interactive, Online Pharmacology Course 3Elsevier/MC Strategies Partners with American Association of Critical-Care Nurses to Launch Interactive, Online Pharmacology Course 4Elsevier/MC Strategies Partners with American Association of Critical-Care Nurses to Launch Interactive, Online Pharmacology Course 5Elsevier/MC Strategies Partners with American Association of Critical-Care Nurses to Launch Interactive, Online Pharmacology Course 6Elsevier/MC Strategies Partners with American Association of Critical-Care Nurses to Launch Interactive, Online Pharmacology Course 7Heska Announces First Installation of New Blood Gas & Electrolyte Analyzer 2Heska Announces First Installation of New Blood Gas & Electrolyte Analyzer 3
MAXM is a reliable benchtop solution for processing mid-size volume workloads. Features include three-dimensional VCS technology, continuous autoloading and easy-to-use data management capabilities....
... LH 755 simplifies and automates ... expert automation and advanced technologies ... reliable, accurate results every time. ... slide quality with its slide-on-slide ...
... from the ground-up with ergonomic concerns in ... most adjustable observation tube on the market. ... user can adjust the microscope to suit ... the operator maintain an upright, comfortable posture, ...
... operates with a simple click of ... Direct the mouse cursor to the ... of the slide and the magnified ... Graphic User Interface (GUI) enables one-click ...
Medicine Products: