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Study finds biologic therapies for rheumatoid arthritis not associated with increased cancer risk
Date:9/4/2012

e disease, but concerns over cancer risk abound because the therapies interfere with the immune system.

The researchers part of MD Anderson's team of internal medicine specialists dedicated to treating cancer patients for medical issues other than cancer used the Cochrane Collaboration to analyze the results of 29,423 adult patients from 63 randomized controlled trials. As a group, the trials selected compared the safety of all nine BRMs currently approved by the FDA against a placebo or traditional DMARD and included only patients with rheumatoid arthritis who had a minimum of six months of follow-up. The Cochrane Collection is an independent, non-profit organization that houses the largest collection of records of randomized controlled trials in the world.

They observed no statistically significant increased risk of any type of cancer in patients treated with BRMs compared with the other medications. In the trials analyzed, 211 patients developed a malignancy during the trial. No significant differences existed between patients in the control group who developed cancer versus those treated with BRM therapies.

"Although additional reviews of observational studies are needed to establish any long-term risk, this is a step forward in understanding overall the risk of developing cancer when taking this newer class of medication," says Suarez-Almazor. "With these results patients and clinicians can make informed decisions about treating rheumatoid arthritis."


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Contact: Julie Penne
jpenne@mdanderson.org
713-792-0622
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

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