Navigation Links
Study finds another potential risk factor for developing dementia and Alzheimer's disease in women
Date:1/2/2012

CHICAGO -- A hormone derived from visceral fat called adiponectin may play a role as a risk factor for development of all-cause dementia and Alzheimer disease (AD) in women, according to a study published Online First by the Archives of Neurology, one of the JAMA/Archives journals.

The number of people affected by dementia worldwide is estimated to double over the next 20 years from the current number of about 36 million people, the authors provide as background information in the article. AD is the most common form of dementia. The authors write that data suggest an association between insulin resistance and inflammation, hallmarks for type 2 diabetes, and development of dementia. "An additional potential factor that may contribute to the onset of AD and all-cause dementia is adiponectin. Adiponectin is a hormone derived from visceral fat, which sensitizes the body to insulin, has anti-inflammatory properties, and plays a role in the metabolism of glucose and lipids."

Thomas M. van Himbergen, Ph.D., from the Lipid Metabolism Laboratory, Human Nutrition Research Center on Aging, Tufts University, Boston, and colleagues measured levels of glucose, insulin, and glycated albumin, as well as C reactive protein, lipoprotein associated phospholipase A2, and adiponectin in the plasma of patients at the 19th biennial examination (1985 1988) of the Framingham Heart Study.

The 840 patients (541 women, median age of 76 years) were followed-up for an average of 13 years and evaluated for signs of the development of AD and all-cause dementia. During that time, 159 patients developed dementia, including 125 cases of AD. After adjustment for other dementia risk factors (age, apoE genotype, low plasma docosahexaenoic acid, weight change) only adiponectin in women was associated with an increased risk of all-cause dementia and AD.

"It is well established that insulin signaling is dysfunctional in the brains of patients with AD, and since adiponectin enhances insulin sensitivity, one would also expect beneficial actions protecting against cognitive decline," the authors write. "Our data, however, indicate that elevated adiponectin level was associated with an increased risk of dementia and AD in women."

"One of the main features of adiponectin is that it has been shown to play a role in the sensitization of insulin and therefore may become a therapeutic target for the treatment of T2D (type 2 diabetes). Surprisingly, a higher adiponectin level was found to be a predictor of all-cause and vascular mortality. In concurrence with the mortality findings, the current investigation shows that an elevated adiponectin level is also an independent predictor for all-cause dementia and AD in women," the authors conclude.


'/>"/>

Contact: Andrea Grossman
andrea.grossman@tufts.edu
617-636-3728
JAMA and Archives Journals
Source:Eurekalert

Related medicine news :

1. Study evaluates effects of marijuana ingredients on brain functioning during visual stimuli
2. Gene Mutations Linked to Thyroid Cancer Risk: Study
3. U.S. Blacks More Likely to Die of Colon Cancer Than Whites: Study
4. Multiple Sclerosis May Cause Changes in Thalamus: Study
5. Silent Strokes Linked to Memory Loss in Elderly: Study
6. Study finds most paramedics are victims of abuse in the workplace
7. Ovarian cancer study proves drug delays disease progression, may improve survival
8. Vitamins, Omega-3s May Keep Brain From Shrinking: Study
9. Adding Lovenox Didnt Reduce Blood Clot Death Risk in Study
10. Some Gluten-Free Beers Really Arent: Study
11. Elderly can be as fast as young in some brain tasks, study shows
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/11/2016)... ... February 11, 2016 , ... Be Well Medical ... in the heart of Old Town at 108 South Columbus St, Suite 201, Alexandria, ... highest level of medical care in the convenience of their homes, offices or at ...
(Date:2/11/2016)... Southborough, MA (PRWEB) , ... February 11, 2016 , ... ... avoid overpaying for IT services, what questions to ask your IT consultant before signing ... them access to your computer network. , “With companies relying heavily on e-mail and ...
(Date:2/10/2016)... (PRWEB) , ... February 10, 2016 , ... ... practitioner, is known locally for a series of therapeutic sessions to help Los ... their characters and in their lives. The series, known as “Mindfulness for Actors ...
(Date:2/10/2016)... ... February 10, 2016 , ... MetLoop CEO Jay Southerland announced ... at the International Roofing Expo in Orlando, Florida on February 17-19. , With ... weather technology in the hands of consumers, roofing contractors, manufacturers and distributors,” Southerland ...
(Date:2/10/2016)... TX (PRWEB) , ... February 10, 2016 , ... ... commencement of a master charity program created to assist the local community. Pledging ... with community leaders and nonprofit organizations in the area. Their goal is to ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... , Feb. 11, 2016  Galmed Pharmaceuticals Ltd. (Nasdaq: ... on the development of a once-daily, oral therapy for ... Chief Medical Officer, Dr. Maya Halpern , has notified ... Chief Medical Officer and from its Board of Directors ... reaching retirement age. Allen Baharaff . Mr. ...
(Date:2/11/2016)... February 11, 2016 North America ... published by MarketsandMarkets, The global market is expected to reach USD ... at a CAGR of 10.2%. --> North America ... 2020", published by MarketsandMarkets, The global market is expected to reach ... growing at a CAGR of 10.2%. --> According to ...
(Date:2/10/2016)... February 11, 2016 ... the "Molecular Diagnostics Reports Bundle" ... http://www.researchandmarkets.com/research/rp4pg8/molecular ) has announced the addition of ... report to their offering. --> ... announced the addition of the "Molecular ...
Breaking Medicine Technology: