Navigation Links
Study findings question benefit of additional imaging before cancer surgery
Date:5/13/2014

Hamilton, ON (May 14, 2014) - Among patients with colorectal cancer which has spread to the liver as determined by computed tomography (CT) scanning, further imaging using positron emission tomography (PET) scans before surgery did not significantly change the surgical treatment of the cancer compared with no further imaging, according to an Ontario Clinical Oncology Group (OCOG) study led by University Health Network researchers.

In Canada, cancer of the colon or rectum (colorectal) is a leading cause of cancer death. Patients with colorectal cancer undergo surgery to remove the cancer, but approximately 50 percent of patients develop spread of the cancer to the liver (liver metastases). Some patients with liver metastases are candidates for liver surgery in order to remove the cancer which can lead to long term survival. However, unidentified metastases outside the liver at the time of surgery can render the operation non-curative and thus futile. Therefore, long-term survival following surgical removal of colorectal cancer liver metastases is relatively low, about 50 percent. The usual practice is to perform a CT scan before surgery to determine the extent of the cancer. Positron emission tomography combined with computed tomography (PET-CT) could help avoid non-curative surgery by identifying patients with hidden metastases.

The findings are published in the May 14 issue of the Journal of the American Medical Association (JAMA).

Principal Investigators, Dr. Carol-Anne Moulton and Dr. Steven Gallinger, and their Ontario colleagues, randomly assigned patients with colorectal cancer with surgically-removable metastases based on CT scans to either PET-CT or no further imaging (control) to determine the effect on the surgical management of these patients.

The study, conducted between 2005 and 2013, enrolled 404 patients and involved 21 surgeons at nine hospitals in Ontario.

Of the 263 patients who received PET-CT scans, 159 had no new information on PET-CT; 49 had new abnormal or suspicious lesions on PET-CT and in 62 the PET-CT did not identify the lesion in the liver identified on the baseline CT. Change in management (canceled, more extensive liver surgery, or surgery performed on additional organs) as a result of the PET-CT findings occurred in 8.7 percent of cases; only 2.7 percent avoided non-curative liver surgery. Overall, liver resection was performed on 91 percent of patients in the PET-CT group and on 92 percent of the control group.

The median follow-up was three years. The researchers found no significant difference in survival or disease-free survival between patients in the PET-CT group versus the control group.

The PET-CAM trial is one of 7 trials that OCOG has performed in recent years as part of the Provincial PET in Oncology Program. The results of these studies have informed policy for the Ontario Ministry of Health & Long Term Care on whether to fund PET for a specific indication. OCOG is the world leader in conducting trials to evaluate the utility of PET in oncology.


'/>"/>
Contact: Veronica McGuire
vmcguir@mcmaster.ca
90-552-591-402-2169
McMaster University
Source:Eurekalert

Related medicine news :

1. Mayo Clinic study identifies strategies that reduce early hospital readmissions
2. Study: Former prisoners, parolees turn to emergency departments for care
3. Surgery study shows worse health, more problems & higher costs among Medicaid patients
4. Study identifies mechanism by which intestinal enzyme maintains microbial balance
5. Study confirms mitochondrial deficits in children with autism
6. Mouse study offers new clues to cognitive decline
7. New study examines premature menopause and effects on later life cognition
8. Study: Concussion rate in high-school athletes more than doubled in 7-year period
9. Mayo Clinic study finds nerve damage after hip surgery may be due to inflammation
10. Study finds increased employee flexibility, supervisor support offer wide-ranging benefits
11. Study finds family-based exposure therapy effective treatment for young children with OCD
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/9/2016)... ... 2016 , ... United Methodist Communications collaborated with Chocolate Moose ... video designed to prevent the next widespread Ebola outbreak from occurring ... distributed throughout Togo, Liberia, Sierra Leone, Nigeria, Côte d’Ivoire and other African countries, ...
(Date:2/9/2016)... (PRWEB) , ... February 09, 2016 , ... ... Mammal Prize has officially been won. A team from 21st Century Medicine (21CM) ... a way to preserve the delicate neural circuits of an intact rabbit brain ...
(Date:2/8/2016)... , ... February 08, 2016 , ... Coast Dental has ... is National Children’s Dental Health Month and family dentist Yvonne Dorrian, DMD, is hosting ... Coast Dental , located next to Target at 1207 North Peachtree Parkway in ...
(Date:2/8/2016)... ... February 08, 2016 , ... ... case packer for pouches, bags, and flow wrapped products at WestPack 2015, February ... specialty product manufacturers step up to semi-automatic or fully-automatic case packing with a ...
(Date:2/8/2016)... ... February 08, 2016 , ... The ... has selected the latest beneficiary of their ongoing community enrichment program. The current ... in area schools. Donations are now being accepted at: http://www.angelsanddoves.com/donate.html . , ...
Breaking Medicine News(10 mins):
(Date:2/8/2016)... --> --> ... Technologies Market by Product (Radiofrequency, Ultrasound, Irreversible Electroporation, Cryotherapy, ... Ophthalmology, Gynecology) - Global Forecasts to 2020", published by ... forecast period of 2015 to 2020. The market is ... of 10.5% from 2015 to 2020. Browse ...
(Date:2/8/2016)... , Feb. 8, 2016 ... the "Global Skin Protective Equipment Market 2016-2020" ... --> http://www.researchandmarkets.com/research/fqx6nz/global_skin ) has announced the addition ... 2016-2020" report to their offering. ... ) has announced the addition of the ...
(Date:2/8/2016)... a historic vote among its members this weekend, the Shinnecock Indian Nation ... and dispensary on tribal land near Southampton . ... for patients in the state,s Medical Cannabis Program. --> ... in the state,s Medical Cannabis Program. --> Tribal members ... designation from the State of New York as ...
Breaking Medicine Technology: