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Study favors as-needed treatment over maintenance therapy for patients with follicular lymphoma
Date:12/12/2011

s for MR-treated FL patients versus 3.6 years for RR-treated patients, rates longer than historical "watch and wait" strategies in this population. At three years of follow-up, 95 percent of MR patients had avoided cytotoxic therapy, as compared with 86 percent of RR patients. Less than 5 percent of patients in the trial experienced any severe hematologic or non-hematologic toxicities. At 12 months after randomization, there was no discernible difference in health-related quality of life or burden of stress between the two study arms.

"In summary, our study found no significant difference between administering maintenance therapy and re-treating with rituximab as needed for this patient population. In addition, given the significant difference in total doses administered, re-treatment with rituximab is less costly than rituximab maintenance therapy," said lead author Brad S. Kahl, MD, Assistant Professor of Medicine at the University of Wisconsin in Madison, Wis. "We believe the re-treatment strategy is the preferred option to help patients with low-tumor-burden FL manage their disease."

Dr. Kahl will present this study in the Late-Breaking Abstracts Session on Tuesday, December 13, at 7:30 a.m. PST at the San Diego Convention Center in Hall AB.


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Contact: Lindsey Love
llove@hematology.org
202-552-4925
American Society of Hematology
Source:Eurekalert

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