Navigation Links
Study favors as-needed treatment over maintenance therapy for patients with follicular lymphoma
Date:12/12/2011

at time of progression is just as effective in managing the disease as ongoing maintenance therapy.

Historically, patients with LTB (defined as small tumor size, limited lymph node involvement, limited or no symptoms, and other factors) disease have been observed rather than treated, with treatment deferred until the patient was symptomatic or the disease progressed, risking the individual's well-being. This has been called the "watch and wait" strategy, which allows physicians to delay chemotherapy treatment for their patients for three years or more. Researchers have hypothesized that rituximab could delay the need for chemotherapy and that maintenance rituximab (MR) would provide disease control superior to rituximab retreatment (RR) when the disease progressed. In order to evaluate the two different rituximab dosing strategies for LTB follicular lymphoma, researchers embarked on the Eastern Cooperative Oncology Group Protocol E4402 (RESORT), a randomized, Phase III clinical trial.

The primary endpoint was time to treatment failure (TTTF), defined as disease that progresses within six months of the last rituximab treatment, disease that doesn't respond to therapy, need for alternative therapy, or inability to complete the treatment protocol. Secondary endpoints included time to first chemotherapy, quality of life (QOL), and safety.

The RESORT trial compared the treatment strategies for 384 patients with previously untreated LTB FL. All patients received rituximab for four weeks, and the 274 patients who achieved a complete or partial response were then randomized to MR (single dose of rituximab every three months, n=140) or RR (four weekly doses of rituximab at disease progression, n=134). Patients were evaluated every three months and were followed until treatment failure. The average number of total doses in the MR arm was 15.8 per patient versus 4.5 doses per patient in the RR arm.

The analysis showed that TTTF was 3.9 year
'/>"/>

Contact: Lindsey Love
llove@hematology.org
202-552-4925
American Society of Hematology
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Despite Treatment, Employees with Depression Generate Higher Absentee Costs, According to Thomson Reuters Study
2. American Council on Exercise (ACE) Study Reveals Kettlebells Provide Powerful Workout in Short Amount of Time
3. TV drama can be more persuasive than news program, study finds
4. Study carried out into biological risks of eating reptiles
5. Neuroimaging study may pave way for effective Alzheimers treatments
6. Study finds racial gaps continue in heart disease awareness
7. Luth Researchs IndicatorEDG(TM) Study Finds Americans Hopes of Achieving Their Dreams Are Fading
8. First blinded study of venous insufficiency prevalence in MS shows promising results
9. Soothing infants with food focus of childhood obesity study
10. People with anxiety disorder less able to regulate response to negative emotions, study shows
11. American Heart Association Rapid Access Journal Report: Study Finds Racial Gaps Continue in Heart Disease Awareness, Low Knowledge of Heart Attack Warning Signs Among Women
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/29/2015)... May 29, 2015 Intermountain ... partnered with Stratus Video Interpreting ... facilitate better communication and timely care for ... hearing loss. Stratus’ video remote interpreting (VRI) ... enabling staff to quickly access qualified medical ...
(Date:5/29/2015)... 29, 2015 Mediaplanet has joined forces ... readers on the importance of proper sun protection. The ... Today, with a circulation of approximately 250,000 copies and ... is distributed nationally, through a vast social media strategy, ... partner outlets. To explore the digital version of the ...
(Date:5/29/2015)... Chicago, Ill (PRWEB) May 29, 2015 ... Care , a dozen medical pioneers recognized by a ... changed the course of cancer treatment. Honorees will be ... of Cancer Care™ Award Ceremony, held 8:30-11:00 p.m. CDT ... , The 2015 honorees are being recognized for groundbreaking ...
(Date:5/29/2015)... TX (PRWEB) May 29, 2015 ... 2015” provides comprehensive information on the therapeutic development ... types of muscles in the body, leading to ... R&D pipelines by identifying new targets and MOAs ... on H1 2015 pipeline review of Axillary Hyperhidrosis ...
(Date:5/29/2015)... Dr. Rodger Murphree, author of ... is now offering free weekly call in teleconferences ... ways to reduce symptoms associated with fibromyalgia including ... brain fog. , To find out more ... call in teleconferences simply go to http://www.endfibronow.com ...
Breaking Medicine News(10 mins):Health News:Stratus Video Interpreting Partners With Intermountain Healthcare to Provide On-Demand Interpretation Services for Patients With Limited English Proficiency (LEP) 2Health News:Stratus Video Interpreting Partners With Intermountain Healthcare to Provide On-Demand Interpretation Services for Patients With Limited English Proficiency (LEP) 3Health News:Stratus Video Interpreting Partners With Intermountain Healthcare to Provide On-Demand Interpretation Services for Patients With Limited English Proficiency (LEP) 4Health News:OncLive's 2015 Giants of Cancer Care™ Awards Announced Today 2Health News:OncLive's 2015 Giants of Cancer Care™ Awards Announced Today 3Health News:OncLive's 2015 Giants of Cancer Care™ Awards Announced Today 4Health News:Muscle Spasm Therapeutic Development Pipeline Review H1 2015 Market Research Report Available at RnRMarketResearch.com 2Health News:Muscle Spasm Therapeutic Development Pipeline Review H1 2015 Market Research Report Available at RnRMarketResearch.com 3Health News:Muscle Spasm Therapeutic Development Pipeline Review H1 2015 Market Research Report Available at RnRMarketResearch.com 4
... PA, January 3, 2011 Postoperative adhesions are a ... used in the hopes of preventing these adhesions by ... in the December 2010 issue of the Journal ... Association of Pediatric Ophthalmology and Strabismus, a team of ...
... entered into a collaborative agreement with Veridex LLC to ... tumor cell (CTC) technologies. The overall goal of the ... capturing and characterizing CTCs, solid tumor cells found at ... a key to noninvasive characterization of cancer and potentially ...
... , SUNDAY, Jan. 2 (HealthDay News) -- Snowblowers ... the white stuff, but while these machines may leave your ... bandage -- or worse, experts warn. A hand surgeon ... accidents can severely injure hands and even require finger amputations ...
... , THURSDAY, Dec. 30 (HealthDay News) -- Certain ... a new study finds. Because of increasing urbanization, ... more than ever before. For example, foxes, raccoons and ... mice, rats, birds and other prey. For this ...
... , , , , , , ... , , AUDIO: ... , Click here for more information. , ... , , , , ...
... THURSDAY, Dec. 29 (HealthDay News) -- Following mothers, advice may ... crisis. Fears of the H1N1 flu virus reached a ... widespread outbreak caused by short supplies of the needed vaccine. ... that,s because more people than ever before regularly washed their ...
Cached Medicine News:Health News:Use of amniotic membrane may cause complications in strabismus surgery 2Health News:Mass. General enters collaboration to develop new approach to capturing circulating tumor cells 2Health News:Risk for alcoholism linked to risk for obesity 2Health News:Risk for alcoholism linked to risk for obesity 3Health News:Risk for alcoholism linked to risk for obesity 4Health News:Hand-Washing May Have Kept Flu at Bay 2Health News:Hand-Washing May Have Kept Flu at Bay 3
(Date:5/29/2015)... MEMPHIS, Tenn. , May 29, 2015  Dr. ... his practice to resolve vaginal health issues often caused by ... painless and requires no anesthesia, received FDA clearance in 2014. ... Tennessee to offer the special fractional CO ... well as breast cancer survivors. In 2010 ...
(Date:5/29/2015)... LifeNet Health plans to enlarge its workforce ... more than 160 people. The organization,s growth ... innovative bio-implants, which are being made more widely available ... It also is a reflection of the region,s growing ... and success of LifeNet Health is a great example ...
(Date:5/29/2015)... and MENLO PARK, Calif. ... DelMar Pharmaceuticals, Inc. (OTCQX: DMPI) ("DelMar" and ... and commercializing proven cancer therapies in new orphan ... American Association of Cancer Research (AACR) Advances ... potential for its lead product candidate VAL-083 ...
Breaking Medicine Technology:The Newest FDA-Cleared Breakthrough In Women's Health Treatments 2LifeNet Health to add more than 160 jobs in 2015 2DelMar Pharmaceuticals Presents Additional Data on the Potential of VAL-083 in the Treatment of Temozolomide-Resistant Glioblastoma Multiforme 2DelMar Pharmaceuticals Presents Additional Data on the Potential of VAL-083 in the Treatment of Temozolomide-Resistant Glioblastoma Multiforme 3DelMar Pharmaceuticals Presents Additional Data on the Potential of VAL-083 in the Treatment of Temozolomide-Resistant Glioblastoma Multiforme 4DelMar Pharmaceuticals Presents Additional Data on the Potential of VAL-083 in the Treatment of Temozolomide-Resistant Glioblastoma Multiforme 5
... AAHC Calls for National Entity to Address Workforce ... center CEOs told congressional staff and representatives of ... that pending health reform legislation does not yet ... to implement successful health system reform. "Pending ...
... AMN Healthcare Services, Inc. (NYSE: AHS ), the ... its quarterly conference call to discuss third quarter results on ... company also expects to issue an earnings news release on ... approximately 4:00 p.m. Eastern Time. , A live webcast of ...
Cached Medicine Technology:Health Reform Bills Still Lack Strategic Focus on Health Workforce 2AMN Healthcare Services to Host 2009 Third Quarter Earnings Conference Call on Thursday, October 29, 2009 2
2.0mm Rounded Tip, 12mm From Tip to Bend Gently Curved, 15mm Shaft; In Titanium...
Double ended with 0.5mm x 10mm and 1.0mm x 15mm blades; both blades gently curved; round serrated handle, In Titanium....
0.6mm Tip x10mm Shaft, Straight Shaft, 90 Degree Hook at Tip; overall length 120mm; in Titianium....
... The SURPASS Perfusion Catheter is ... the stenotic portion of a ... stenosis for the purpose of ... Perfusion Catheters are also designed ...
Medicine Products: