Navigation Links
Study expected to boost research for hearing and balance therapies

CHARLOTTESVILLE, VA (September 25, 2007) Birds, fish and amphibians can do something that humans and other mammals generally cannot: re-grow damaged or lost inner ear hair cells.

Loss of these cells causes hearing deficiencies and disabling balance problems in an estimated 250 million people worldwide. Despite the compelling need for new treatments, research and development efforts have been hindered by the relative scarcity of inner ear hair cells. A new study by neuroscientists at the University of Virginia Health System promises to boost cell supplies and accelerate therapeutic advancements.

Humans and other mammals only produce hair cells before birth and lose them over time. People lose hair cells in their inner ear for many reasons trauma, infections, drug toxicity, genetic disorders and aging, explains Jeffrey T. Corwin, PhD, professor of Neuroscience at the University of Virginia Health System and co-author of a study published this month in the Proceedings of the National Academy of Sciences (PNAS).

Sensory cells in the inner ear have hair bundles that detect the presence of sound. These cells are not only essential for hearing but help to control reflexes that stabilize our visual world, posture and movements. While hair cell loss remains clinically irreversible in humans, related research indicates that the potential for regeneration lies in the supporting cells of our balance organs.

In the UVa study, Dr. Corwin and his co-author, Dr. Zhengqing Hu, describe a new method of growing inner ear hair cells in the laboratory. They isolated cells from the inner ears of chicken embryos and perpetuated the cells in tissue culture. The researchers grew the cultures over several months, froze them and then thawed and greatly expanded the numbers of cells. Then, they discovered methods for causing hair cells to differentiate within the growing cultures.

We produced the equivalent of test-tube inner ear hair cells, Dr. Hu says.

The methods developed at UVa are expected to provide a new, reliable source of cells and expand research efforts. Without adequate supplies of hair cells, it has been difficult to study factors that promote and inhibit their growth, explains Dr. Corwin. We hope our findings increase the scope and pace of inner ear research that is ultimately designed to benefit of millions of people around the world who are affected by hearing and balance impairments.


Contact: Ellen McKenna
University of Virginia Health System

Related medicine news :

1. Rural Canadians travel far for specialists: study
2. A new study surpasses Gene Therapy Hurdle
3. Tomato Sauce reduces Cancer Risk- Study
4. A question on study of Adult Stem Cell
5. Study on obesity and heart failure
6. National Lung Study in the process
7. Marijuana gateway theory strengthened by study of twins
8. Old theory of adaptation confirmed by new study
9. Study casts doubt on keyboard ills
10. Gene study links endometriosis, infertility
11. Study reveals how stress can make you sick
Post Your Comments:
(Date:6/26/2016)... ... , ... On June 10-11, 2016, A Forever Recovery, a holistic treatment center ... Breakfast Table in Battle Creek, MI, where the rehabilitation facility is located. This annual ... the world’s leading providers of cereal and other breakfast foods. Its residents often refer ...
(Date:6/25/2016)... ... 2016 , ... Experts from the American Institutes for Research ... June 26-28, 2016, at the Hynes Convention Center in Boston. , AIR experts ... planning, healthcare costs and patient and family engagement. , AIR researchers will be ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, Dr. Omkar Marathe ... from the David Geffen School of Medicine at UCLA. He trained in Internal Medicine ... his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic events may ... to unhealthy avenues, such as drug or alcohol abuse, as a coping mechanism. To ... for healthy coping following a traumatic event. , Trauma sufferers tend to feel a ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience with all ... brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... 27, 2016 Jazz Pharmaceuticals plc (Nasdaq: ... the Hart-Scott-Rodino Antitrust Improvements Act of 1976, as amended ... Pharmaceuticals, Inc. ("Celator"; Nasdaq: CPXX ) expired ... Time). As previously announced on May 31, ... merger agreement under which Jazz Pharmaceuticals has commenced a ...
(Date:6/24/2016)... , June 24, 2016  Collagen Matrix, ... design, development and manufacturing of collagen and mineral ... announced today that Bill Messer has ... Marketing to further leverage the growing portfolio of ... devices. Bill joins the Collagen Matrix ...
(Date:6/24/2016)... 24, 2016 Research and ... "Structural Electronics 2015-2025: Applications, Technologies, Forecasts" report ... In-Mold Electronics, Smart Skin, Structural Health Monitoring, ... Structural electronics involves electronic and/or electrical components ... replacing dumb structures such as vehicle bodies or ...
Breaking Medicine Technology: