Navigation Links
Study examines whether lower blood pressure reduces kidney disease progression
Date:3/21/2011

AUGUSTA, Ga. Georgia Health Sciences University is enrolling patients in a federally funded study to determine if a lower blood pressure reduces the progression of kidney disease.

"The question is, if you have kidney disease, should your blood pressure goal be lower?" said Dr. Laura Mulloy, Chief of the GHSU Section of Nephrology and a principal investigator for the Systolic Blood Pressure Intervention Trial, or SPRINT, funded by the National Institutes of Health.

The standard is to keep the systolic pressure the top number indicating pressure inside blood vessels when the heart pumps below 140 for those with signs of kidney damage. GHSU physician scientists will help about half of the 100 patients they enroll in the study get that number below 120.

Additionally, the study will measure the lower pressure's impact on cognitive function.

High blood pressure affects about 1 in 3 Americans. Often dubbed the "silent killer" many patients are unaware they are hypertensive until their kidneys begin failing.

Population-based and observational studies suggest lower blood pressure is healthier for the brain and the kidney but this is the first clinical study to objectively measure the impact.

High blood pressure is a major risk factor for stroke, kidney disease and other maladies but at a certain point low pressure can become problematic as well, Mulloy said. "You have to weigh the risk-benefit ratio," she said. "We would like for the blood pressure to be controlled optimally, but at the same time not have blood pressure so low that it impairs patients' ability to function."

Only about one third of Americans with unhealthy blood pressure achieve adequate blood pressure control. "We have to be vigilant in getting blood pressure to reach targeted goals," said Mulloy, citing the combination of a healthy, low-salt diet, exercise and often more than one medication.

"I think we can get people to goal," said Dr. Matt Diamond, GHSU nephrologist and SPRINT co-investigator, whose hypertension and nephrology service has helped close to 60 percent of its patients obtain good control. "It's clear that a better blood pressure slows the progression of kidney disease. We want to know if a lower blood pressure can do even better."

Participants in the SPRINT trial need to be age 55 and older with chronic kidney disease. Those already taking high blood pressure medication are eligible; participants will be placed or kept on commonly used drugs such as ACE inhibitors and diuretics. Diabetics are ineligible because of the condition's risk of kidney failure.

The researchers will follow study participants for up to six years, regularly checking baseline measures such as blood pressure; levels of creatinine, a breakdown product that can be measured in the blood as an indicator of kidney function; and cognitive function.

Nationally about 4,300 patients with chronic kidney disease will be followed. A parallel study is exploring the impact of a lower blood pressure on cardiovascular disease.


'/>"/>

Contact: Toni Baker
tbaker@georgiahealth.edu
706-721-4421
Georgia Health Sciences University
Source:Eurekalert  

Related medicine news :

1. Study suggests alternative treatment for bacteria in oysters
2. Reported Pollen Counts May Be Inaccurate, Study Finds
3. Study Ties Asthma to Higher Odds for Diabetes, Heart Disease
4. Domestic Abuse Often Escapes Notice of ER Staff: Study
5. Small Study Finds Hearing Loss in 1 in 4 College Students
6. Germs Thrive on Horns Passed Around in School Bands: Study
7. Rat Study Sheds Light on How Alcohol Affects Young Brain
8. In pilot study, screening detects potentially serious heart conditions in healthy children
9. Risk of hospital patient mortality increases with nurse staffing shortfalls, study finds
10. When Nurse Staffing Drops, Mortality Rates Rise: Study
11. Stephen J. Teach, MD, MPH, part of landmark study on pediatric asthma
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study examines whether lower blood pressure reduces kidney disease progression
(Date:5/26/2017)... , ... May 26, 2017 , ... Amir Qureshi, MD ... a powerfully versatile, patient-centric spinal cord stimulation system. The Nuvectra™ Algovita SCS System has ... are pleased to be the first in Arkansas to introduce the most powerful SCS ...
(Date:5/26/2017)... ... May 26, 2017 , ... Boar’s ... sharing bold recipes for Memorial Day entertaining that are sure to satisfy your ... Head fresh sliced meats and cheeses featured in these refreshingly balanced recipes are ...
(Date:5/26/2017)... ... May 26, 2017 , ... After raising nearly $30,000 on Kickstarter , ... be available at a discounted crowdfunding price on Indiegogo . , “Along with ... also wanted to bring a fidget toy to the market that was made of ...
(Date:5/26/2017)... ... May 26, 2017 , ... Rob Lowe acts as host ... of the series is on hiking in American. Viewers can reconnect with America as ... benefits of hiking. , Many consumers have looked for an inventive new place for ...
(Date:5/26/2017)... ... ... Journey to the Cross”: the personal journey of Bob Massey and his faith in the ... Bob and Margaret Massey. Bob Massey is small in stature but big in character. ... His love for others is apparent in all of his life decisions. , “I’m ...
Breaking Medicine News(10 mins):
(Date:5/15/2017)... , May 15, 2017 Enterin Inc., a ... and developing novel compounds to treat Parkinson,s disease (PD), ... study is a Phase 1/2a randomized, controlled, multicenter study involving ... It will enroll 50 patients over a 9-to-12-month period. The ... in 10 patients with PD. Participating sites include ...
(Date:5/10/2017)...  The Corporate Whistleblower Center says, "We are ... clinics to call us anytime at 866-714-6466 if they ... in a substantial scheme to overbill Medicare. We ... employee of a medical equipment company if their ... medical practice groups with extra generous incentives to use, ...
(Date:5/9/2017)... -- Oramed Pharmaceuticals Inc. (NASDAQ: ORMP ) ... on the development of oral drug delivery systems, ... has granted Oramed a patent titled, "Methods and ... covers Oramed,s invention of an oral glucagon-like peptide-1 ... hormone that stimulates the secretion of insulin from ...
Breaking Medicine Technology: