Navigation Links
Study examines risk factors for cancer in unaffected breast of breast cancer patients
Date:1/26/2009

A new study identifies certain patient and tumor characteristics that may help indicate which breast cancer patients would be the most likely to benefit from preventive surgery to remove the unaffected breast. Published in the March 1, 2009 issue of CANCER, a peer-reviewed journal of the American Cancer Society, the study could help patients with breast cancer make more informed treatment choices.

Women diagnosed with breast cancer are known to be at increased risk of developing breast cancer in the opposite breast, either at the time of diagnosis or some time in the future. Identifying which women are most at risk of cancer in the other breast could help patients decide whether to have preventive treatment, including mastectomy to remove the unaffected breast. While a fairly drastic measure, some women may choose this option due to a variety of factors, such as advice from their physician, fear of another breast cancer diagnosis, desire for cosmetic symmetry and family history of breast or other cancers.

While most breast cancer patients would not experience any survival benefit from such a contralateral prophylactic mastectomy, it is difficult to determine which patients should consider the procedure. If physicians could predict which patients are at the highest risk of developing contralateral breast cancer and which are not, many patients could preserve their unaffected breast if desired.

To identify the factors that predict contralateral breast cancer, Dr. Kelly K. Hunt and colleagues at the University of Texas M. D. Anderson Cancer Center in Houston studied 542 patients who had breast cancer in one breast and who had both breasts removed between 2000 and 2007.

From the prophylactic mastectomy specimen, the researchers found that twenty-five patients (5 percent) had contralateral breast cancer, and 82 patients (15 percent) had cells in the other breast that were abnormal and could signify higher risk for breast cancer development.

When the investigators looked for clinical features associated with contralateral breast cancer, they found three independent factors: when the cancer cells had certain histologic invasive characteristics; when the cancer was present in more than one quadrant of the breast; and when the patient had a 5-year Gail risk of 1.67 percent or greater. The Gail model is a breast cancer risk assessment tool used for women without a cancer diagnosis that takes into consideration a woman's medical history, age, race and other characteristics.

Also, women aged 50 years or older at the initial cancer diagnosis or who had additional moderate- to high-risk cells in their affected breast were likely to have abnormal cells in the other breast that could potentially develop into cancer.


'/>"/>

Contact: David Sampson
david.sampson@cancer.org
American Cancer Society
Source:Eurekalert

Related medicine news :

1. Penn study finds pro-death proteins required to regulate healthy immune function
2. New study shows promise in reducing surgical risks associated with surgical bleeding
3. Study, meta-analysis examine factors associated with death from heatstroke
4. Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinsons symptoms
5. Study says COPD testing is not measuring up
6. Preclinical study suggests organ-transplant drug may aid in lupus fight
7. Ability to cope with stress can increase good cholesterol in older white men, study finds
8. High alcohol consumption increases stroke risk, Tulane study says
9. Mailman School of Public Health study examines link between racial discrimination and substance use
10. Pitt study finds inequality in tobacco advertising
11. Stanford study highlights cost-effective method of lowering heart disease risks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/12/2016)... (PRWEB) , ... February 12, 2016 , ... ... Lean Leadership Series at Zuckerberg San Francisco General Hospital on April 5-7. The ... new behaviors and create new habits. The workshops cover a broad range of ...
(Date:2/12/2016)... ... February 12, 2016 , ... Every winter, someone is ... winter the West Penn Burn Center, part of the Allegheny Health Network, ... to bring you the “Space Heaters Need Space” campaign. , “Space Heaters ...
(Date:2/12/2016)... ... 12, 2016 , ... AssureVest Insurance Group, a locally owned insurance firm with ... will raise funds earmarked to purchase computers and software for Mrs. Harrison’s 2nd and ... is in a low-income area and has more than 60 2nd and 3rd graders ...
(Date:2/12/2016)... ... ... Vail knee specialist Robert LaPrade, MD, PhD was named one of ... of physicians establishing, leading and partnering with ambulatory surgery centers across the United States. ... also known as an ASC, is a modern health care facility focused on providing ...
(Date:2/12/2016)... , ... February 12, 2016 , ... ... the Pittsburgh metro area, celebrates the beginning of the latest charity campaign in ... social skills through art. Donations to this worthy cause are currently being accepted ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... AUSTIN, Texas , Feb. 12, 2016 ... Institute for Robotic Surgery at St. David,s North Austin ... the da Vinci ® Xi ® Surgical ... ® 7000dV. Thiru Lakshman , M.D., ... performed a total proctocolectomy utilizing Integrated Table Motion technology, ...
(Date:2/12/2016)... , 12 februari 2016 ... een toonaangevende leverancier van productie en ontwikkeling ... industrieën, kondigt vandaag een uitbreiding aan van ... haar locatie in Charleston, SC ... geleid tot meerdere recente investeringen. ...
(Date:2/11/2016)... 2016 The primary goal of this research ... on the usage of liquid biopsy. Key information the ... - Timeframe of liquid biopsy adoption amidst future users ... organization type - Sample inflow to conduct liquid biopsy ... serum, and so on. - Correlation analysis of sample ...
Breaking Medicine Technology: