Navigation Links
Study examines risk factors for cancer in unaffected breast of breast cancer patients
Date:1/26/2009

A new study identifies certain patient and tumor characteristics that may help indicate which breast cancer patients would be the most likely to benefit from preventive surgery to remove the unaffected breast. Published in the March 1, 2009 issue of CANCER, a peer-reviewed journal of the American Cancer Society, the study could help patients with breast cancer make more informed treatment choices.

Women diagnosed with breast cancer are known to be at increased risk of developing breast cancer in the opposite breast, either at the time of diagnosis or some time in the future. Identifying which women are most at risk of cancer in the other breast could help patients decide whether to have preventive treatment, including mastectomy to remove the unaffected breast. While a fairly drastic measure, some women may choose this option due to a variety of factors, such as advice from their physician, fear of another breast cancer diagnosis, desire for cosmetic symmetry and family history of breast or other cancers.

While most breast cancer patients would not experience any survival benefit from such a contralateral prophylactic mastectomy, it is difficult to determine which patients should consider the procedure. If physicians could predict which patients are at the highest risk of developing contralateral breast cancer and which are not, many patients could preserve their unaffected breast if desired.

To identify the factors that predict contralateral breast cancer, Dr. Kelly K. Hunt and colleagues at the University of Texas M. D. Anderson Cancer Center in Houston studied 542 patients who had breast cancer in one breast and who had both breasts removed between 2000 and 2007.

From the prophylactic mastectomy specimen, the researchers found that twenty-five patients (5 percent) had contralateral breast cancer, and 82 patients (15 percent) had cells in the other breast that were abnormal and could signify higher risk for breast cancer development.

When the investigators looked for clinical features associated with contralateral breast cancer, they found three independent factors: when the cancer cells had certain histologic invasive characteristics; when the cancer was present in more than one quadrant of the breast; and when the patient had a 5-year Gail risk of 1.67 percent or greater. The Gail model is a breast cancer risk assessment tool used for women without a cancer diagnosis that takes into consideration a woman's medical history, age, race and other characteristics.

Also, women aged 50 years or older at the initial cancer diagnosis or who had additional moderate- to high-risk cells in their affected breast were likely to have abnormal cells in the other breast that could potentially develop into cancer.


'/>"/>

Contact: David Sampson
david.sampson@cancer.org
American Cancer Society
Source:Eurekalert

Related medicine news :

1. Penn study finds pro-death proteins required to regulate healthy immune function
2. New study shows promise in reducing surgical risks associated with surgical bleeding
3. Study, meta-analysis examine factors associated with death from heatstroke
4. Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinsons symptoms
5. Study says COPD testing is not measuring up
6. Preclinical study suggests organ-transplant drug may aid in lupus fight
7. Ability to cope with stress can increase good cholesterol in older white men, study finds
8. High alcohol consumption increases stroke risk, Tulane study says
9. Mailman School of Public Health study examines link between racial discrimination and substance use
10. Pitt study finds inequality in tobacco advertising
11. Stanford study highlights cost-effective method of lowering heart disease risks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/20/2017)... ... January 20, 2017 , ... A new partnership between ... they no longer use or need, from clothes to couches to dressers and bicycles. ... and take them to the nearest Goodwill donation center through February 28th. , ...
(Date:1/20/2017)... Miami, Florida (PRWEB) , ... January 20, 2017 , ... ... in head lice cases in families with school-aged children since the holiday season. ... spend the holidays with their families, sharing hugs and taking photos, which is the ...
(Date:1/20/2017)... ... January 20, 2017 , ... ... its sugar-free alternative VW+ 002. The drinks have been produced in collaboration with ... to perform during your workout. , After a successful launch in Sweden last ...
(Date:1/20/2017)... ... 2017 , ... D R Burton Healthcare Products LLC, makers ... in a study indicating superior performance against competitive products in secretion clearance. ... Positive Expiratory Pressure Devices During Simulated Breathing“ was published in the winter issue ...
(Date:1/20/2017)... ... January 20, 2017 , ... “God's Miracle Man: Against All Odds”: an ... of published author, Keith C. A. Tucker, son of Minister Delores Pinnock and a ... by Reverend Mark Hardy , “While sitting up in bed, I felt a pounding ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... 19, 2017 Shire plc (LSE: ... U.S. Food and Drug Administration (FDA) has acknowledged receipt ... Application (NDA) for SHP465, a long-acting, triple-bead, mixed amphetamine ... once-daily treatment for Attention-Deficit/Hyperactivity Disorder (ADHD). The FDA is ... 20, 2017, the designated Prescription Drug User Fee Act ...
(Date:1/19/2017)... 19, 2017 Pfizer joins ... Milner Therapeutics Consortium   Major research ... Cambridge   The Milner Therapeutics ... ) as a partner to the Milner Therapeutics Consortium. ... the efficient transfer of materials between industry and academia ...
(Date:1/19/2017)... Florida , January 19, 2017 ... Trump administration appears serious about reducing the FDA,s ... and innovation in the medical drug industry, many ... ahead with new clinical trials and development of ... companies forging ahead with recent developments include:  Moleculin ...
Breaking Medicine Technology: