Navigation Links
Study examines global availability of treatment involving transplantation of blood stem cells
Date:4/27/2010

This release is available in Chinese.

An examination of the world-wide use of hematopoietic stem cell transplantation (HSCT), which involves transplantation of blood stem cells derived from the bone marrow or blood, finds that there are significant differences in transplant rates between countries and continental regions by indication and donor type, and that HSCT is most frequently used in countries with higher gross national incomes and governmental health care expenditures, according to a study in the April 28 issue of JAMA.

"HSCT has become the standard of care for many patients with defined congenital or acquired disorders of the hematopoietic system [pertaining to the formation of blood cells] or with chemosensitive, radiosensitive, or immunosensitive malignancies. Over the last 2 decades, HSCT has seen rapid expansion in use and a constant evolution in its technology," the authors write. "It requires significant infrastructure and a network of specialists from all fields of medicine. Hence, information on indications, use of specific technologies, and trends in the application of HSCT is essential for correct patient counseling and for health care agencies to prepare the necessary infrastructure and to avoid planning errors." Little is known about HSCT use and the factors associated with it on a global level.

Alois Gratwohl, M.D., of University Hospital Basel, Switzerland, and colleagues conducted a study to assess differences in the application of HSCT on a global level and to examine associations of various factors with transplant rates. The study included patients receiving allogeneic (genetically different) and autologous (derived from the same individual) HSCTs for 2006, collected by 1,327 centers in 71 participating countries of the Worldwide Network for Blood and Marrow Transplantation. The regional areas used in this study were (1) the Americas (the corresponding World Health Organization regions are North and South America); (2) Asia (Southeast Asia and the Western Pacific Region, which includes Australia and New Zealand); (3) Europe (includes Turkey and Israel); and (4) the Eastern Mediterranean and Africa.

A total of 50,417 first HSCTs were reported for 2006; 43 percent were allogeneic, 57 percent autologous. Most of the autologous HSCTs occurred in the Americas and Europe. The most frequent malignant disease for an allogeneic HSCT was acute myeloid leukemia (33 percent); the most frequent nonmalignant disease was bone marrow failure syndrome (6 percent); and the most frequent indication for an autologous HSCT was a plasma cell disorder (41 percent).

"Use of allogeneic or autologous HSCT, unrelated or family donors for allogeneic HSCT, and proportions of disease indications varied significantly between countries and regions. In linear regression analyses, government health care expenditures, HSCT team density (indicates the number of transplant teams per one million inhabitants), human development index, and gross national income per capita showed the highest associations with HSCT rates," the authors write.

Most of the 50,417 HSCTs were performed in Europe (48 percent), followed by the Americas (36 percent), Asia (14 percent), and the Eastern Mediterranean and Africa (2 percent). The median (midpoint) HSCT rates (per 10 million inhabitants) varied between the continental regions and between participating countries, from 48.5 in the Americas, 184 in Asia, 268.9 in Europe, and 47.7 in the Eastern Mediterranean and Africa. No HSCTs were performed in countries with less than 300,000 inhabitants, smaller than 960 km2, or having less than U.S. $680 gross national income per capita.

"In conclusion, this global overview on HSCT activity demonstrates that it is an accepted therapy worldwide, with different needs and priorities in different regions. Transplant activity is concentrated in countries with higher health care expenditures, higher gross national income per capita, and higher team density; hence, the availability of resources, governmental support, and access to a transplant center determine regional HSCT activity," the researchers write.


'/>"/>

Contact: Alois Gratwohl, M.D.
hematology@uhbs.ch
JAMA and Archives Journals
Source:Eurekalert

Related medicine news :

1. Study finds that drugs used for treatment of influenza in pregnancy appear to be safe
2. Comparative-effectiveness study confirms new treatment for diabetic macular edema
3. CureTogether Announces Online Autism Treatment Study
4. LA BioMed awarded research grant to study HIV prevention gel
5. Study Makes Strides in Understanding Ovarian Cancer
6. Brown Rice Tied to Better Heart Health in Study
7. NIH study confirms location of stem cells near cartilage-rich regions in bones
8. Immune cells predict success of head and neck cancer treatment, U-M study finds
9. Noncardiac Chest Pain May Warrant More Management: Study
10. SGIC Study Finds Drivers Are Losing Their Cool At School
11. Health impacts of mobile phone use to be explored in huge new study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/6/2016)... ... 2016 , ... Research has shown that building shame resilience ... and level of relapse. , At the 2016 iaedp Symposium, the ... the critical tasks of the recovery phase and beyond including relapse prevention and ...
(Date:2/5/2016)... ... February 05, 2016 , ... Love is in the ... a variety of colors, assortments and packaging. This staple for Valentine’s Day is a ... location. , For Valentine’s Day, not only are long-stem roses available, but also ...
(Date:2/5/2016)... City, UT (PRWEB) , ... February 05, 2016 , ... ... Whole-Food Nutrition , announced that the much-anticipated feature with author Jahnavi Foster, specialist in ... Humans Amateur TV Network. , Each week, on his weekly Whole-Food Warrior TV show, ...
(Date:2/5/2016)... ... February 05, 2016 , ... The event is being held ... Event Center in Minneapolis, Minn. Triumph Over Parkinson’s will fund nearly $100,000 for research ... Schneiderman’s Furniture, lives with Parkinson’s disease and is the architect of this informative event ...
(Date:2/5/2016)... Santa Rosa, CA (PRWEB) , ... February 05, ... ... are pleased to announce the addition of micro-needling services in their Napa Valley ... appearance. The founders of Plastic Surgery Associates, Dr. Canales and Dr. Furnas, are ...
Breaking Medicine News(10 mins):
(Date:2/4/2016)... 2016 Wegener Polyangiitis - Pipeline Review, ... ,Wegener Polyangiitis - Pipeline Review, H2 2015, provides ... This report provides comprehensive information on the ... analysis at various stages, therapeutics assessment by drug ... (RoA) and molecule type, along with latest updates, ...
(Date:2/4/2016)... -- Omnicell, Inc. (NASDAQ: OMCL ), a leading provider of ... announced results for its fiscal year and fourth quarter ... --> GAAP results: Revenue for the fourth quarter ... 4.1% from the third quarter of 2015, and up ... 2014. Revenue for the year ended December 31, 2015 was ...
(Date:2/4/2016)... 2016  Blueprint Medicines Corporation (NASDAQ: BPMC ... selective investigational kinase medicines for patients with genomically ... board of directors of Lonnel Coats , ... of industry-related experience. Jeffrey Albers ... strong strategic experience developing and commercializing numerous oncology ...
Breaking Medicine Technology: