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Study examines endoscopic ultrasound-guided drainage of pancreatic pseudocysts
Date:10/21/2013

DOWNERS GROVE, Ill. October 21, 2013 Researchers report that in patients with pseudocysts with viscous debris-laden fluid, endoscopic ultrasound-guided drainage by using a combination of a nasocystic drain and transmural stents improves clinical outcomes and lowers the stent occlusion rate compared with those who underwent drainage via stents alone. The study appears in the October issue of GIE: Gastrointestinal Endoscopy, the monthly peer-reviewed scientific journal of the American Society for Gastrointestinal Endoscopy (ASGE).

A pancreatic pseudocyst consists of a localized fluid collection that is within or adjacent to the pancreas and is sealed in a fibrous wall of reactive tissue. Pseudocysts develop in 10 percent to 20 percent of patients with acute pancreatitis (inflammation of the pancreas) and are present in 20 percent to 40 percent of patients with chronic pancreatitis. Indications for drainage of the pseudocyst include persistent intra-abdominal symptoms (ie, abdominal pain, early satiety, nausea and vomiting), cyst-related adverse events (biliary obstruction or infection), and/or a rapid increase in cyst size. The management of pseudocysts traditionally has been surgical. However, surgical management has been associated with a 35 percent adverse-event rate and mortality of 10 percent. Endoscopic ultrasound-guided transmural drainage is a minimally invasive method for the management of pseudocysts. Clinical trials have demonstrated that EUS-guided drainage is as effective as surgery, causes fewer adverse events, and is more cost-effective compared with surgery.

Most studies on the endoscopic treatment of pseudocysts have evaluated the use of one or more endoprostheses (hollow stents or tiny tubes that are inserted into the pseudocyst to allow drainage into the stomach or duodenal lumen) alone for transgastric or transduodenal drainage. EUS-guided drainage has now been recognized as the standard procedure for the management
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Contact: Anne Brownsey
abrownsey@asge.org
630-570-5635
American Society for Gastrointestinal Endoscopy
Source:Eurekalert

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