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Study examines association between Parkinson disease, cancer
Date:9/3/2012

yo Clinic, Rochester, Minn., writes: "The findings from Kareus et al, combined with previous findings in the literature, suggest that some families have a genetic predisposition that can manifest as PD, as other types of parkinsonism, as essential tremor, as cognitive impairment or dementia, as amyotrophic lateral sclerosis, as anxiety disorders, as depressive disorders, or as nonneurological conditions such as melanoma and prostate cancer."

"If the mechanisms are primarily genetic, as suggested by Kareus and colleagues, then it may be possible to identify genetic variants that predispose to accelerated neurodegeneration and to increased oncogenesis in the same individual or among members of some particular families," Rocca continues.

"On the other hand, if PD is multifactorial at the individual level, dimorphic in men and women, and heterogeneous at the population level, the search for one or several genetic variants may not be productive," Rocca concludes.

(Arch Neurol. Published online September 3, 2012. doi:10.1001/archneurol.2012.2664. Available pre-embargo to the media at http://media.jamanetwork.com.)

Editor's Note: Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.


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Contact: Kathy Wilets
kathy.wilets@hsc.utah.edu
801-581-5717
JAMA and Archives Journals
Source:Eurekalert

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