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Study examines association between Parkinson disease, cancer
Date:9/3/2012

in their relatives. A reciprocal significantly increased relative risk for PD was found in 7,841 Utah melanoma cases and their relatives," the study results indicate.

Among the individuals with PD who died, the authors observed 48 cases of melanoma. The estimated RR for melanoma in patients with PD who died was 1.95; and an increased risk for death with PD was noted among the patients with melanoma (RR, 1.65). Researchers also found prostate cancer in 212 patients with PD who died (RR, 1.71) and an increased risk for death with PD was found among the prostate cancer patients (RR, 1.39), according to the results.

"Thus, these data argue strongly for a significant shared genetic risk for specific cancers on the one hand and neurodegeneration on the other. .These studies provide a framework for future definition of the precise nature of shared genetic variation leading to neurodegeneration in some individuals, but skin or prostate cancers in others, and they may influence strategies for skin and prostate cancer screening," the authors conclude.

(Arch Neurol. Published online September 3, 2012. doi:10.1001/archneurol.2012.2261. Available pre-embargo to the media at http://media.jamanetwork.com.)

Editor's Note: Two authors disclosed grant support, with one author disclosing consulting fees and speaking honoraria. This research was supported by the Utah Cancer Registry, which is funded by a contract from the National Cancer Institute's Surveillance, Epidemiology and End Results program, with additional support from the Utah State Department of Health and the University of Utah. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

Editorial: Families with Parkinson Disease, Cancer

In an editorial, Walter A. Rocca, M.D., M.P.H., of the Ma
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Contact: Kathy Wilets
kathy.wilets@hsc.utah.edu
801-581-5717
JAMA and Archives Journals
Source:Eurekalert

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