Navigation Links
Study examines association between Parkinson disease, cancer
Date:9/3/2012

CHICAGO A study that used a Utah genealogic database and a statewide cancer registry to examine the relationship between Parkinson disease (PD) and cancer suggests an increased risk of prostate cancer and melanoma in patients with PD and their relatives, according to a report published Online First by Archives of Neurology, a JAMA Network publication.

Neurodegenerative diseases, in particular PD, may share common pathogenic mechanisms with some cancers, according to the study background.

"Identifying a genetic relationship between PD and cancer is critical to understanding underlying pathophysiologic changes in both diseases. Understanding this relationship could allow clinicians to provide proper assessment of cancer risk in patients with PD and might also have implications for the counseling of relatives of patients," the authors note in the study background.

Seth A. Kareus, M.D., and colleagues from the University of Utah, Salt Lake City, estimated relative risks (RRs) for cancer in individuals with PD listed on their death certificate, and in their relatives. The study identified 2,998 patients with PD listed as their cause of death from 1904 to 2008 and also included information from the Utah Cancer Registry on 100,817 patients diagnosed with cancer.

To validate their observed associations, researchers also estimated the reciprocal RR for PD death among patients diagnosed with melanoma and their relatives, and estimated the RRs for death with PD among patients diagnosed with prostate cancer and their relatives.

"A significantly increased risk for prostate cancer was observed in the PD population as well as among their relatives. A reciprocal significantly increased risk for PD was also found in the 22,147 prostate cancer cases and their relatives," according to the study results.

The study also notes that "a significantly elevated risk for melanoma was found in the Utah PD population as well as in their relatives. A reciprocal significantly increased relative risk for PD was found in 7,841 Utah melanoma cases and their relatives," the study results indicate.

Among the individuals with PD who died, the authors observed 48 cases of melanoma. The estimated RR for melanoma in patients with PD who died was 1.95; and an increased risk for death with PD was noted among the patients with melanoma (RR, 1.65). Researchers also found prostate cancer in 212 patients with PD who died (RR, 1.71) and an increased risk for death with PD was found among the prostate cancer patients (RR, 1.39), according to the results.

"Thus, these data argue strongly for a significant shared genetic risk for specific cancers on the one hand and neurodegeneration on the other. .These studies provide a framework for future definition of the precise nature of shared genetic variation leading to neurodegeneration in some individuals, but skin or prostate cancers in others, and they may influence strategies for skin and prostate cancer screening," the authors conclude.

(Arch Neurol. Published online September 3, 2012. doi:10.1001/archneurol.2012.2261. Available pre-embargo to the media at http://media.jamanetwork.com.)

Editor's Note: Two authors disclosed grant support, with one author disclosing consulting fees and speaking honoraria. This research was supported by the Utah Cancer Registry, which is funded by a contract from the National Cancer Institute's Surveillance, Epidemiology and End Results program, with additional support from the Utah State Department of Health and the University of Utah. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

Editorial: Families with Parkinson Disease, Cancer

In an editorial, Walter A. Rocca, M.D., M.P.H., of the Mayo Clinic, Rochester, Minn., writes: "The findings from Kareus et al, combined with previous findings in the literature, suggest that some families have a genetic predisposition that can manifest as PD, as other types of parkinsonism, as essential tremor, as cognitive impairment or dementia, as amyotrophic lateral sclerosis, as anxiety disorders, as depressive disorders, or as nonneurological conditions such as melanoma and prostate cancer."

"If the mechanisms are primarily genetic, as suggested by Kareus and colleagues, then it may be possible to identify genetic variants that predispose to accelerated neurodegeneration and to increased oncogenesis in the same individual or among members of some particular families," Rocca continues.

"On the other hand, if PD is multifactorial at the individual level, dimorphic in men and women, and heterogeneous at the population level, the search for one or several genetic variants may not be productive," Rocca concludes.

(Arch Neurol. Published online September 3, 2012. doi:10.1001/archneurol.2012.2664. Available pre-embargo to the media at http://media.jamanetwork.com.)

Editor's Note: Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.


'/>"/>
Contact: Kathy Wilets
kathy.wilets@hsc.utah.edu
801-581-5717
JAMA and Archives Journals
Source:Eurekalert

Related medicine news :

1. Mathematics or memory? Stanford study charts collision course in brain
2. Few Doctors Discuss Exercise With Cancer Patients: Study
3. Study explores why children with asthma are more likely to be bullied
4. Marathons Safe for Aging Boomers, Study Finds
5. Womens Brains React Differently Than Mens to Alcoholism, Study Finds
6. Smoking After Stroke Triples Risk of Death Within Year: Study
7. Study looks at efforts to improve local food systems through policy
8. Keeping Up a Healthy Lifestyle Pays Off in Added Years: Study
9. Hookah Effects as Harmful as Cigarettes, Study Finds
10. BUSM researchers study use of MRI in osteoarthritis
11. Survival More Likely With Exercise-Related Cardiac Arrest: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... , ... June 24, 2016 , ... Marcy was in a crisis. Her son James, ... out at his family verbally and physically. , “When something upset him, he couldn’t control ... use it. He would throw rocks at my other children and say he was going ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, CA is ... Road To Recovery® program to drive cancer patients to and from their cancer treatments. ... the highest quality of life and ongoing independence. Getting to and from medical ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... is proud to recognize Dr. Barry M. Weintraub as a prominent plastic surgeon ... beautiful women in the world, and the most handsome men, look naturally attractive. ...
(Date:6/24/2016)... ... June 24, 2016 , ... Venture Construction Group (VCG) ... held on June 20th at the Woodmont Country Club at 1201 Rockville Pike, ... organization dedicated to helping service members that have been wounded in battle and their ...
(Date:6/24/2016)... ... 24, 2016 , ... To succeed under value-based payments, healthcare ... unsure how to move forward, given the need to sustain current operations. PYA ... to an organization’s specific needs. , PYA Principal Martie Ross states, “Healthcare providers ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... -- Roche (SIX: RO, ROG; OTCQX: RHHBY) announced that ... PCT (procalcitonin) assay as a dedicated testing solution for ... clearance, Roche is the first IVD company in the ... risk assessment and management. PCT is a ... in blood can aid clinicians in assessing the risk ...
(Date:6/23/2016)... , June 23, 2016 Bracket , a ... its next generation clinical outcomes platform, Bracket eCOA (SM) ... on June 26 – 30, 2016 in Philadelphia ... electronic Clinical Outcome Assessment product of its kind to fully ... Bracket eCOA 6.0 is a flexible platform for ...
(Date:6/23/2016)... Revolutionary technology includes multi-speaker listening to conquer ... in advanced audiology and hearing aid technology, has today ... world,s first internet connected hearing aid that opens up ...      (Photo: http://photos.prnewswire.com/prnh/20160622/382240 ) , ... , TwinLink™ - the first dual communication ...
Breaking Medicine Technology: