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Study evaluates 'normal range' systolic bp levels after ischemic stroke and risk of recurrent stroke
Date:11/15/2011

CHICAGO Among patients who experienced an ischemic stroke, systolic blood pressure levels of less than 120 mm Hg, or higher than 140 mm Hg, were associated with an increased risk of subsequent stroke, according to a study appearing in the November 16 issue of JAMA, a theme issue on cardiovascular disease. This issue is being released early online to coincide with the American Heart Association Scientific Sessions.

"Recurrent stroke prevention guidelines suggest that larger reductions in systolic blood pressure (SBP) are positively associated with a greater reduction in the risk of recurrent stroke and define an SBP level of less than 120 mm Hg as normal. However, the association of SBP maintained at such levels with risk of vascular events after a recent ischemic stroke is unclear," according to background information in the article.

Bruce Ovbiagele, M.D., M.Sc., of the University of California, San Diego, and colleagues evaluated the association of SBP maintained within a low-normal range vs. high-normal range with clinical outcomes among patients who recently experienced an ischemic stroke. The study consisted of an observational analysis of a multicenter trial involving 20,330 patients (age 50 years or older) with recent non-cardioembolic (not due to small blood clots originating within the heart) ischemic stroke from who were recruited from 695 centers in 35 countries from September 2003 through July 2006 and followed up for 2.5 years (follow-up ended in February 2008). Patients were categorized based on their average SBP level: very low-normal (less than 120 mm Hg), low-normal (120 to less than 130 mm Hg), high-normal (130 to less than 140 mm Hg), high (140 to less than 150 mm Hg), and very high (150 mm Hg or greater).

Occurrence of the primary measured outcome (stroke) was greatest in the very high SBP level group (14.1 percent), followed by the high SBP group (8.7 percent), the very low-normal SBP group (8.0 percent),
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Contact: Scott LaFee
slafee@ucsd.edu
619-543-6163
JAMA and Archives Journals
Source:Eurekalert

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