Navigation Links
Study drug is first to help patients with recurrent low-grade ovarian cancer
Date:2/8/2013

HOUSTON - Low-grade serous ovarian cancer is less common and aggressive than the high-grade variety, yet exceptionally difficult to treat when frontline therapy fails.

"After surgery, with or without pre-surgical chemotherapy, when low-grade serous ovarian cancer persists or returns, chemotherapy and hormonal therapy are relatively ineffective," said David Gershenson, M.D., professor in The University of Texas MD Anderson Cancer Center Department of Gynecological Oncology and Reproductive Medicine.

Response rates for treatment are measured in single digits. Gershenson and colleagues have spent the greater part of 20 years characterizing the disease, which makes up 10 percent of ovarian cancer cases, and searching for new ways to treat it. Cancer recurs or persists in 80 to 85 percent of patients.

A phase II clinical trial by the National Cancer Institute's Gynecological Oncology Group provides the first evidence of a drug that shows a relatively high response rate for these patients.

Selumetinib halts growth or shrinks tumors

In the first-targeted therapy clinical trial for low-grade serous ovarian cancer, eight of 52 (15 percent) patients had a complete or objective partial response (tumor shrinkage) and 34 (65 percent) had no disease progression during the two-year course of the study. Study results appear in the February edition of The Lancet Oncology.

"These are remarkably encouraging results for what can ultimately be a devastating disease," said Gershenson, the paper's senior author.

These patients have a median overall survival of 80 months, about twice as long as those with high-grade disease, who are typically in their 60s when diagnosed and comprise 90 percent of ovarian cancer patients. The average age of women with low-grade cancer falls in the early 40s, Gershenson said, and it's not uncommon to see women in their 20s, 30s and 40s and the occasional teenager with the d
'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Study Suggests Vaccine May Help Kids With Brain Cancer
2. Study reveals how cancer drug causes diabetic-like state
3. Coffee Drinking in Pregnancy Wont Lead to Sleepless Baby: Study
4. Lower GI problems plague many with rheumatoid arthritis, Mayo Clinic study finds
5. Veggies Like Broccoli, Cabbage May Help Fight Breast Cancer: Study
6. No Added Cancer Risk From Hip Replacement Materials: Study
7. Reported Decline in U.S. Pneumonia Deaths May Be False: Study
8. Early Study Finds Some Promise for Lung Cancer Vaccine
9. Narcissists Often Ace Job Interviews, Study Finds
10. Sexual objectification of female artists in music videos exists regardless of race, MU study finds
11. Soy may alleviate hot flashes in menopause, large-scale study finds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study drug is first to help patients with recurrent low-grade ovarian cancer
(Date:9/16/2014)... Kathleen Doheny HealthDay Reporter ... urine test can routinely spot human papillomavirus (HPV), which is ... found. "Our study shows that testing urine for HPV ... the cervix for HPV," said lead researcher Dr. Neha Pathak. ... fellow at Queen Mary University of London, England. The ...
(Date:9/16/2014)... 2014 These new programs allow those who ... receive up to $10,000 in a 0% interest free, 2nd ... other state and federal programs, are listed on their private ... until you sell or move out of the property. The ... loan. There are no monthly payments paid by the Borrower. ...
(Date:9/16/2014)... A new study found that fractional flow ... true coronary bifurcation lesions yields similar outcomes to ... trial is the first study to compare FFR-guided ... today at the 26th annual Transcatheter Cardiovascular Therapeutics ... Foundation (CRF), TCT is the world,s premier educational ...
(Date:9/16/2014)... Washington, DC (PRWEB) September 16, 2014 ... could potentially yield hundreds of billions of dollars in ... 2007 report by the Commonwealth Fund. To help spur ... is seeking up to 10 collaborative groups from across ... 1.0 ( http://bit.ly/1wo4gsa ) - a handbook designed ...
(Date:9/16/2014)... Angeles, CA (PRWEB) September 16, 2014 ... League of United Latin American Citizens (LULAC) will host ... LULAC’s Feria de Salud will feature free health screenings ... Other free testing includes glucose and cholesterol levels as ... will be available for children under 6 years old ...
Breaking Medicine News(10 mins):Health News:Urine Test for HPV Works Well, Analysis Finds 2Health News:New Updated 2014 First Time Home Buyer Programs Available to Florida Residents 2Health News:New Updated 2014 First Time Home Buyer Programs Available to Florida Residents 3Health News:Results of DKCRUSH-VI trial reported at TCT 2014 2Health News:NQF Seeks Field Testing Groups for Population Health Guide 2Health News:NQF Seeks Field Testing Groups for Population Health Guide 3Health News:LULAC Hosts Second Annual Latinos Living Healthy Feria de Salud in Los Angeles 2
... ... is giving away 10,000 free business card pens. , ... (PRWEB) December 2, 2009 -- National Pen ( www.pens.com ), a ... pens. , , , , ,“We have a new way to promote business that no ...
... ... direct microwave signal transmissions away from users will be available in early 2010 from ... ... signal transmissions away from users will be available in early 2010 from Aerius International ...
... ... and walkers from Las Vegas and around the country will cross the ... by Zappos.com, raising over $3.2 million for the Crohn,s & Colitis Foundation ... charity of the race, the funds will go toward research, education, and ...
... 2 The American Health Information Management Association,s Board ... be the next chief executive of the 55,000-member health ... information experience includes academia, systems management, strategic expertise, governance ... scheduled to take office January 13, 2010. , "Dr. ...
... , , WASHINGTON, Dec. ... 2 in their campaign against the U.S. House bill,s pro-life ... CEO Charmaine Yoest released this statement in response to the ... "By confusing abortion with health care, the feminist groups and ...
... Washington Post Highlights Dangers , WASHINGTON, ... way, many medical treatments and preventative measures we take for granted may ... to bear on the debate over healthcare reform has been widely reported. ... likely impact if that pressure to influence healthcare policy is not curtailed. ...
Cached Medicine News:Health News:National Pen Giving Away 10,000 Business Card Pens 2Health News:New AERIUS Cell Phones Direct Microwave Signals Away from Users 2Health News:Raising Millions for Team Challenge through Rock ‘n' Roll Las Vegas Half Marathon Program Brings Hundreds From Across the Country to Raise Funds for Crohn's & Colitis 2Health News:Raising Millions for Team Challenge through Rock ‘n' Roll Las Vegas Half Marathon Program Brings Hundreds From Across the Country to Raise Funds for Crohn's & Colitis 3Health News:Raising Millions for Team Challenge through Rock ‘n' Roll Las Vegas Half Marathon Program Brings Hundreds From Across the Country to Raise Funds for Crohn's & Colitis 4Health News:Dr. Alan F. Dowling Named AHIMA's Next Chief Executive Officer 2Health News:Everybody's Healthcare Is Threatened by Catholic Bishops' Interference 2
(Date:9/16/2014)... , Sept. 16, 2014 Astellas announced ... of Business Communications & Advocacy, Urology in the ... Communications & Advocacy Margaret Long. In this role, Noland ... urology to patient and advocacy organizations, as well ... key strategic initiatives. Noland,s appointment is the latest ...
(Date:9/16/2014)... YORK , Sept. 16, 2014 This report ... by the following Product Segments: Devices, and Medication. The report ... , Japan , Europe ... America , and Rest of World. Annual estimates and ... a seven-year historic analysis is provided for these markets. Market ...
(Date:9/16/2014)... Wash. , Sept. 16, 2014 /PRNewswire/ ... a late stage development company engaged primarily ... medical isotopes for diagnostic and therapeutic applications, ... for technology related to its brachytherapy products.  ... arise from its license from Battelle, under ...
Breaking Medicine Technology:Christy Noland to Lead Urology Advocacy and Communications for Astellas 2Global Foot Care Products Industry 2Global Foot Care Products Industry 3Global Foot Care Products Industry 4Global Foot Care Products Industry 5Global Foot Care Products Industry 6Global Foot Care Products Industry 7Global Foot Care Products Industry 8Global Foot Care Products Industry 9Global Foot Care Products Industry 10Global Foot Care Products Industry 11Global Foot Care Products Industry 12Global Foot Care Products Industry 13Global Foot Care Products Industry 14Global Foot Care Products Industry 15Global Foot Care Products Industry 16Global Foot Care Products Industry 17Global Foot Care Products Industry 18Global Foot Care Products Industry 19Global Foot Care Products Industry 20Global Foot Care Products Industry 21Global Foot Care Products Industry 22Advanced Medical Isotope Corporation Licensed Brachytherapy Seed Patent Granted 2Advanced Medical Isotope Corporation Licensed Brachytherapy Seed Patent Granted 3Advanced Medical Isotope Corporation Licensed Brachytherapy Seed Patent Granted 4
... loss of Arf gene in presence of BCR-ABL ... of the bone,marrow, helping cells develop immunity to ... 29 Results of a study,by investigators at ... why the drug imatinib (Gleevec(TM)), which has revolutionized,the ...
... from Roche-, MONTVALE, N.J., Aug. 29 ... the dosing of the,first subject in the single ... program of R4996/MEM 63908, a partial agonist of ... could be beneficial in,the treatment of Alzheimer,s disease ...
Cached Medicine Technology:St. Jude Discovers Factors That Accelerate Resistance to Gleevec(TM) Targeted Therapy in Lymphoblastic Leukemia 2Memory Pharmaceuticals Commences Phase 1 Clinical Program for R4996/MEM 63908 2Memory Pharmaceuticals Commences Phase 1 Clinical Program for R4996/MEM 63908 3
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: