Navigation Links
Study documents toll of smoke inhalation injuries
Date:11/16/2011

MAYWOOD, Il. -- A study of burn patients has found that those who suffered the most severe smoke inhalation also had more inflammation and spent more time on ventilators and in intensive care.

The study, led by researchers at Loyola University Chicago Stritch School of Medicine, is published ahead of print in the journal Critical Care Medicine. It is the first to show that the severity of smoke-inhalation injury may play a role in the overall pulmonary inflammatory response.

Inflammation occurs in response to injury. It includes the release of proteins that can trigger wound healing. But too much inflammation can damage healthy tissue.

Researchers wrote that their findings could "serve the purpose of better understanding the biological mechanisms behind smoke inhalation injury."

In the United States, about 40,000 people are hospitalized for burn injuries each year. As many as 20 percent of fire victims also have smoke-inhalation injuries.

At Loyola, smoke inhalation is rated from 0 (no injury) to 4 (massive injury). Researchers conducted an observational study of 60 adult burn patients, including nine patients who had Grade 0 inflammation, 15 who had Grade 1, 15 who had Grade 2, 18 who had Grade 3 and three who had Grade 4.

The study included an examination of proteins called cytokines contained in fluid flushed out of patients' lungs. (Cytokines are the so-called hormones of the immune system.) Researchers looked at 28 cytokines associated with inflammation, and found that 21 were at their highest in patients with the most severe smoke inhalation injuries. (The inflammatory proteins included interferon-γ, granulocyte-macrophage colony-stimulating factor, monocyte chemotactic protein-1 and several interleukins.)

Patients who had low smoke-inhalation injuries (Grades 1 or 2) spent a median of seven days on the ventilator, while patients with high-inhalation injuries (Grades 3 or 4) spent a median of 23 days on the ventilator. Low-inhalation-injury patients spent a median of 13 days in intensive care; high-inhalation-injury patients spent 24 days. Thirty-three percent of low-inhalation-injury patients required a tracheotomy, compared with 52 percent of high-inhalation-injury patients. However, the degree of inhalation injury did not have a significant effect on subsequent pneumonia, sepsis, hospital length of stay or mortality.

Senior author of the study is Elizabeth J. Kovacs, PhD, director of Loyola's Burn and Shock Trauma Institute. First author is Joslyn M. Albright, MD, a research fellow in the Burn and Shock Trauma Institute. "This study is an excellent example of clinicians and basic scientists working together," Kovacs said.


'/>"/>

Contact: Jim Ritter
jritter@lumc.edu
708-216-2445
Loyola University Health System
Source:Eurekalert

Related medicine news :

1. LGBT seniors face harder old age, national study finds
2. Wayne State University to study novel treatment for antibiotic-resistant bacteria
3. Blood Type May Be Associated With Stroke Risk: Study
4. Psoriasis is associated with impaired HDL function, Penn study finds
5. CU-Boulder led study of smoking twins points to growing influence of genetic factors
6. Southeast U.S. Still Using High Levels of Antibiotics, Study Shows
7. Women, Younger Men Under-Treated Before Heart Attack: Study
8. Study Finds Link Between Low IQ, Large Waistline
9. Whole-Body Vibration Doesnt Build Bone After All: Study
10. Alcoholics More Likely to Die of Cancer: Study
11. High Doses of Statins Tied to Less Arterial Plaque in Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... California (PRWEB) , ... June 25, 2016 , ... "With ... fit their specific project," said Christina Austin - CEO of Pixel Film Studios. ... customizable and all within Final Cut Pro X . Simply select a ProHand ...
(Date:6/25/2016)... ... 2016 , ... On Friday, June 10, Van Mitchell, Secretary of the Maryland ... iHire in recognition of their exemplary accomplishments in worksite health promotion. , The Wellness ... & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was one of ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World Sickle Cell ... pain and the benefits of holistic treatments, Serenity Recovery Center of Marne, ... Cell Disease. , Sickle Cell Disease (SCD) is a disorder of the red blood ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience with all ... brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary ...
(Date:6/24/2016)... ... June 24, 2016 , ... EB Medicine presented its ... Emergency Medicine conference in Ponte Vedra Beach, FL. The awards honor the outstanding ... Medicine Practice and Pediatric Emergency Medicine Practice. , “With this award, we ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... 2016 Jazz Pharmaceuticals plc (Nasdaq: ... Hart-Scott-Rodino Antitrust Improvements Act of 1976, as amended ("HSR"), ... Inc. ("Celator"; Nasdaq: CPXX ) expired effective ... As previously announced on May 31, 2016, ... agreement under which Jazz Pharmaceuticals has commenced a tender ...
(Date:6/24/2016)... 24, 2016  Consumers have taken a more ... placed more emphasis on patient outcomes. ... in the pharmaceutical industry have evolved beyond just ... companies are focusing on becoming more patient-oriented across ... and services that improve health. ...
(Date:6/24/2016)... , June 24, 2016   Bay Area ... Network,s Dean Center for Tick Borne Illness ... and Rehabilitation, MIT Hacking Medicine, University of California, ... today announced the five finalists of Lyme ... disease.  More than 100 scientists, clinicians, researchers, entrepreneurs, ...
Breaking Medicine Technology: