Navigation Links
Study details structure of potential target for HIV and cancer drugs
Date:10/7/2010

read of cancer cells. To date, CXCR4 has been linked to more than 20 types of cancer.

The Scripps Research scientists set out to shed light on how CXCR4 functions by capturing snapshots of the protein by using a structure determination method called X-ray crystallography. To understand how natural molecules might bind and signal through the receptor and to see how potential drugs could interact with it, they examined CXCR4 bound to known inhibitors of its activity.

Determining the structure of CXCR4 represented a major challenge because membrane proteins are notoriously tricky to coax into the crystal form required for the X-ray technique. After three years of optimizing conditions for producing, stabilizing and crystallizing the molecule, the scientists finally generated five distinct structures of CXCR4.

The structures showed that CXCR4 molecules form closely linked pairs, confirming data from other experiments indicating that pairing plays a role in the proper functioning of the receptor. With this knowledge, scientists can delve into how the duos might regulate CXCR4's activity and better understand how CXCR4 functions under normal and disease conditions.

The images also showed that CXCR4 is shaped like two white wine glasses touching in a toast, with the inhibitors bound at the sides of the bowls. By detailing these contacts, the researchers said the pictures suggest how to design compounds that regulate CXCR4 activity or block HIV entry into cells. If developed into drugs, such compounds could offer new ways to treat HIV infection or cancer.

"An approach to determining protein structures that was developed with support from the NIH Common Fund and the PSI is now paying huge dividends," said Jeremy M. Berg, Ph.D., director of the National Institute of General Medical Sciences, which supports the PSI. "It illustrates how technical progress provides a foundation for rapid advances, and it also showcases the benefits o
'/>"/>

Contact: Emily Carlson
carlsone@nigms.nih.gov
301-496-7301
NIH/National Institute of General Medical Sciences
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Denser Breasts Raise Odds of Second Breast Cancer, Study Finds
2. U-M receives NIH, FDA grant to study adaptive clinical trial designs
3. Stanford-led study disproves link between genetic variant, risk of coronary artery disease
4. Study shows faith-based interventions can encourage exercise in older African-American women
5. Study links large waist size to higher diabetes rates among Americans
6. Drink or Two a Week While Pregnant Might Not Harm Baby: Study
7. Provocative new Montreal study probes link between breast cancer and air pollution
8. UF study: Emotional effects of heavy combat can be lifelong for veterans
9. MFM researcher earns $3.7M NIH grant to study preterm birth
10. New study highlights sexual behavior, condom use by US individuals ages 14 to 94
11. Study focuses on mephedrone use in Northern Ireland post-ban
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study details structure of potential target for HIV and cancer drugs
(Date:7/30/2014)... WEDNESDAY, July 30, 2014 (HealthDay News) -- It can happen ... television, dresser or computer monitor and gets critically injured ... of a young child should look around their homes and ... a child. Imagining it is better than it becoming a ... Emergency Physicians, said in a college news release. Between ...
(Date:7/30/2014)... to fuel cancer as well as evolutionary changes in ... that occur randomly throughout the genome. , However, recent ... formation of multiple mutations that arise simultaneously and in ... mutations are frequently found in regions where chromosomal rearrangements ... Cell Reports , may one day lead to ...
(Date:7/30/2014)... (PRWEB) July 30, 2014 Visitors to ... contributed over $8,500 to ensure its protection. Bob Kiesendahl, ... a check to the Delaware Highlands Conservancy for donations ... The small $2-per-stay donations add up fast, as visitors ... the Upper Delaware River Region. , The Kiesendahl family ...
(Date:7/30/2014)... 2014) The phrase "we caught it early" is possibly ... midst of a cancer diagnosis. Combating cancer in its ... certain part of the body, gives patients the best ... colon, prostate and other forms of cancer are touted ... providers recommend cancer screenings as a precautionary measure, especially ...
(Date:7/30/2014)... ... ... ... , UCLA ... For the study, published this week in the peer-reviewed journal Quality of Life Research , a UCLA team led by Dr. ...
Breaking Medicine News(10 mins):Health News:Tip-Over Furniture Can Kill Kids 2Health News:Biologists describe mechanism promoting multiple DNA mutations 2Health News:Pocono Mountain Resort Guests Contribute Over $8500 to Protect Land in 6 Short Months 2Health News:UK psychologist creates patient tool to assist with lung cancer screening decision 2Health News:UK psychologist creates patient tool to assist with lung cancer screening decision 3Health News:Diverticulitis patients reveal psychological, physical symptoms long after acute attacks 2Health News:Diverticulitis patients reveal psychological, physical symptoms long after acute attacks 3
... A University of Melbourne study has revealed that certain ... link between mammographic breast density and breast cancer. ... Health says women vary greatly in their underlying risk ... possible new pathways into the development of breast cancer." ...
... Del.Feb. 16, 2010 Cancer , the peer-reviewed international ... a study conducted by HealthCore, Inc. in its ... treatment between commercially insured African-American and white women. ... of previous studies conducted in populations using ...
... team of researchers has found that adding a humanized monoclonal ... new or enlarged brain lesions in patients with relapsing multiple ... and in the March edition of the Lancet Neurology ... which the body,s immune system attacks the fatty substance that ...
... Celebrity ... will be awarded $5,000 for best eye care tips., , ... Atlanta, GA (Vocus) February 16, 2010 -- Just as people ... the AIR OPTIX AQUA brand team is partnering with Carmindy, makeup artist on TLC’s hit ...
... with the worst cases report the fewest nightmares, study finds ... that accompany severe sleep apnea may be counterbalanced by this ... , "We found that people with significant sleep apnea have ... fewer nightmares," said Dr. Jim Pagel, lead author of a ...
... ... the use of social tools. , ... Minneapolis, MN (PRWEB) February 16, 2010 -- BusinessCard2 ™, a ... of the Social Business Innovation Awards. The competition was established to recognize great ...
Cached Medicine News:Health News:Study reveals genetic link between mammographic density and breast cancer 2Health News:Cancer publishes study confirming disparity in breast cancer treatment 2Health News:Promising therapy for relapsing multibple sclerosis 2Health News:Promising therapy for relapsing multibple sclerosis 3Health News:CIBA VISION Partners with TLC's Carmindy to Educate Consumers About Healthy Eye Habits 2Health News:CIBA VISION Partners with TLC's Carmindy to Educate Consumers About Healthy Eye Habits 3Health News:CIBA VISION Partners with TLC's Carmindy to Educate Consumers About Healthy Eye Habits 4Health News:Severe Sleep Apnea Has Silver Lining 2Health News:Severe Sleep Apnea Has Silver Lining 3Health News:BusinessCard2 Wins Social Business Innovation Award 2Health News:BusinessCard2 Wins Social Business Innovation Award 3
(Date:7/30/2014)... LAS VEGAS , July 30, 2014  DigiPath, ... provider that is expanding into the cannabis testing and ... development in its business and affairs not previously disclosed ... for the recent unusual market action. "We ... securities over the last three trading days," said ...
(Date:7/30/2014)... /PRNewswire-iReach/ -- This is a professional and in-depth ... (CAS 9041-08-1) & calcium (CAS 37270-89-6) industry. The ... sodium (CAS 9041-08-1) & calcium (CAS 37270-89-6) including ... then explores global and China,s top manufacturers of ... listing their product specification, capacity, production value, cost, ...
(Date:7/30/2014)... VILLAGE, Nev. , July 30, 2014  PDL ... announced that company management will participate in the Jefferies ... Boston , Massachusetts. The conference will occur on August ... About PDL BioPharma, Inc. PDL BioPharma manages ... of its Queen et al. antibody humanization patents and ...
Breaking Medicine Technology:DigiPath No New Corporate Developments 2Heparin Sodium & Calcium Industry for Global and Chinese Markets Forecast to 2019 2Heparin Sodium & Calcium Industry for Global and Chinese Markets Forecast to 2019 3Heparin Sodium & Calcium Industry for Global and Chinese Markets Forecast to 2019 4Heparin Sodium & Calcium Industry for Global and Chinese Markets Forecast to 2019 5PDL BioPharma to Participate in Jefferies 2014 Boston Healthcare Summit 2
Lyphochek Coagulation Control is a human plasma control for monitoring the performance of routine coagulation tests. It has an extended reconstituted stability which helps reduce waste and save money...
Lyphochek® Hemoglobin A1C Linearity Set is a human whole blood based product designed to verify linearity throughout the patient reportable range of hemoglobin A1C assays....
... Hematology-16 Control is specifically ... most hematology analyzers that ... parameters and 3-part white ... trilevel control can be ...
Each Liquichek Seroconversion Panel features a series of serum specimens drawn over time from one individual to show the progression from a negative to a positive disease state....
Medicine Products: