Navigation Links
Study details structure of potential target for HIV and cancer drugs
Date:10/7/2010

read of cancer cells. To date, CXCR4 has been linked to more than 20 types of cancer.

The Scripps Research scientists set out to shed light on how CXCR4 functions by capturing snapshots of the protein by using a structure determination method called X-ray crystallography. To understand how natural molecules might bind and signal through the receptor and to see how potential drugs could interact with it, they examined CXCR4 bound to known inhibitors of its activity.

Determining the structure of CXCR4 represented a major challenge because membrane proteins are notoriously tricky to coax into the crystal form required for the X-ray technique. After three years of optimizing conditions for producing, stabilizing and crystallizing the molecule, the scientists finally generated five distinct structures of CXCR4.

The structures showed that CXCR4 molecules form closely linked pairs, confirming data from other experiments indicating that pairing plays a role in the proper functioning of the receptor. With this knowledge, scientists can delve into how the duos might regulate CXCR4's activity and better understand how CXCR4 functions under normal and disease conditions.

The images also showed that CXCR4 is shaped like two white wine glasses touching in a toast, with the inhibitors bound at the sides of the bowls. By detailing these contacts, the researchers said the pictures suggest how to design compounds that regulate CXCR4 activity or block HIV entry into cells. If developed into drugs, such compounds could offer new ways to treat HIV infection or cancer.

"An approach to determining protein structures that was developed with support from the NIH Common Fund and the PSI is now paying huge dividends," said Jeremy M. Berg, Ph.D., director of the National Institute of General Medical Sciences, which supports the PSI. "It illustrates how technical progress provides a foundation for rapid advances, and it also showcases the benefits o
'/>"/>

Contact: Emily Carlson
carlsone@nigms.nih.gov
301-496-7301
NIH/National Institute of General Medical Sciences
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Denser Breasts Raise Odds of Second Breast Cancer, Study Finds
2. U-M receives NIH, FDA grant to study adaptive clinical trial designs
3. Stanford-led study disproves link between genetic variant, risk of coronary artery disease
4. Study shows faith-based interventions can encourage exercise in older African-American women
5. Study links large waist size to higher diabetes rates among Americans
6. Drink or Two a Week While Pregnant Might Not Harm Baby: Study
7. Provocative new Montreal study probes link between breast cancer and air pollution
8. UF study: Emotional effects of heavy combat can be lifelong for veterans
9. MFM researcher earns $3.7M NIH grant to study preterm birth
10. New study highlights sexual behavior, condom use by US individuals ages 14 to 94
11. Study focuses on mephedrone use in Northern Ireland post-ban
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study details structure of potential target for HIV and cancer drugs
(Date:4/17/2015)... 2015 Testosterone treatment lawsuits ( ... prescription medications increases the likelihood that a man ... life-threatening cardiovascular event continue to mount in a ... District of Illinois. According to an updated Statistics ... Multidistrict Litigation (JPML) on April 15th, 1,382 cases ...
(Date:4/17/2015)... Scientists from the Icahn School ... U.S. and Venezuelan researchers, have discovered the most ... an isolated tribe of Yanomami Amerindians in the ... the Yanomami, previously unexposed to antibiotics or industrialized ... of people living in industrialized countries, and was ...
(Date:4/17/2015)... Bronx, NY (PRWEB) April 17, 2015 Calvary ... Calvary Fund, Inc. as Executive Vice President on May 11. ... Hospital’s unique and historic mission. Barr succeeds Vincent J. Spinelli, ... Tim has agreed to take on and supervise the important ... Calamari, president and CEO. “As Calvary continues to expand and ...
(Date:4/17/2015)... NJ (PRWEB) April 17, 2015 ... in the posterior pituitary and thought to help mothers ... between couples. To further substantiate this, new studies performed, ... the journal, Nature, and reported by Medical News Today ... a powerful influence over maternal social behavior. The study ...
(Date:4/17/2015)... Mario Badescu Botanical Exfoliating ... facial skin with its unique combination of finely ... energizing botanicals. This cushiony gel-based formula sloughs off ... and inhibit penetration of special treatments, serums, and ... Seeds, This uncommon exfoliating ingredient is an ecologically ...
Breaking Medicine News(10 mins):Health News:Testosterone Treatment Lawsuits Increase, as New Report Indicates Over 200 Federal Cases Filed Since March 2Health News:Testosterone Treatment Lawsuits Increase, as New Report Indicates Over 200 Federal Cases Filed Since March 3Health News:Testosterone Treatment Lawsuits Increase, as New Report Indicates Over 200 Federal Cases Filed Since March 4Health News:Mount Sinai Scientists Find Unprecedented Microbial Diversity in Isolated Amazonian Tribe Previously Unexposed to Antibiotics or Processed Foods 2Health News:Mount Sinai Scientists Find Unprecedented Microbial Diversity in Isolated Amazonian Tribe Previously Unexposed to Antibiotics or Processed Foods 3Health News:Timothy P. Barr Appointed Executive Vice President of Calvary Fund 2Health News:Timothy P. Barr Appointed Executive Vice President of Calvary Fund 3Health News:Oxytocin Now Found to Help Diet Doc Patients Whose Weight Has Gotten out of Control Due to Emotional Eating Disorders 2Health News:Oxytocin Now Found to Help Diet Doc Patients Whose Weight Has Gotten out of Control Due to Emotional Eating Disorders 3Health News:Mario Badescu Skin Care Launches Botanical Exfoliating Scrub 2
... As hooking up takes over from dating as a means ... continue to prefer dating whereas more men than women rate ... and risks to dating and hooking up. Carolyn Bradshaw from ... reasons that motivate college men and women to hook up ...
... this as troubling individually and for society , WEDNESDAY, ... mobility are increasing among middle-age Americans, a new study ... long-term consequences for the U.S. health-care system. , Researchers ... data from the annual National Health Interview Survey, covering ...
... Home ... to create, save and export HH CAHPS Survey data for three leading HH CAHPS ... , ... 7, 2010 -- Kinnser Software, Inc. introduces a new service enabling home health agencies ...
... ... tested for reliable operation in the most extreme environments. This rugged system uses a ... daylight. The SDC100HB is specifically designed for the uncompromising requirements of applications in the ... ...
... ... The Centers for Disease Control advise that even after being rinsed ... exposed to more germs now than in the past decades and ... exposure and infection. ,DrTung’s new kids’ snap-on toothbrush sanitizer uses lions ...
... Mount Sinai researchers of over eight years of dietary data ... between high consumption of fruits and vegetables and a reduced ... The study is published online April 6, 2010 in the ... is widely believed that a diet rich in fruits and ...
Cached Medicine News:Health News:Hooking up or dating: Who benefits? 2Health News:Middle-Age Americans Less Mobile Than Ever 2Health News:Kinnser Software Supports HH CAHPS Survey Data Export to Three Approved HH CAHPS Survey Vendors 2Health News:Kinnser Software Supports HH CAHPS Survey Data Export to Three Approved HH CAHPS Survey Vendors 3Health News:Kinnser Software Supports HH CAHPS Survey Data Export to Three Approved HH CAHPS Survey Vendors 4Health News:Rugged High Bright Touch Screen Computer Designed and Tested for the Most Extreme Environments 2Health News:Rugged High Bright Touch Screen Computer Designed and Tested for the Most Extreme Environments 3Health News:'Animals' Keep Germs Away From Kids' Toothbrushes 2Health News:Mount Sinai study finds only a weak link between fruit and vegetable and reduced risk of cancer 2
(Date:4/17/2015)... DETROIT , April 17, 2015  In Detroit, where ... infant mortality rate is two and one half times of ... Nearly 6 of 10 infants that die in ... are sobering statistics that Covenant Community Care, a faith-based, charitable ... is poised to change thanks to a charitable donation by ...
(Date:4/17/2015)...  Over the next five years, the marijuana industry in ... predicting that 14 more states will legalize recreational marijuana and ... for legal cannabis grew 74 percent in 2014 to $2.7 ... market could grow more than fourfold to $11 billion in ... on marijuana. Cannabiz Mobile Inc. (OTCBB: LGBI) is ...
(Date:4/17/2015)... Apr. 16, 2015 Research and Markets ... "Corporate Reputation of Pharma in 2014 - a ... report to their offering. This independent study, ... patient groups with an interest in diabetes on the ... the pharma industry as a whole) in 2014. The ...
Breaking Medicine Technology:Covenant Community Care to Receive Donated SONIMAGE P3 Handheld Ultrasound from Konica Minolta Medical Imaging 2Covenant Community Care to Receive Donated SONIMAGE P3 Handheld Ultrasound from Konica Minolta Medical Imaging 3Covenant Community Care to Receive Donated SONIMAGE P3 Handheld Ultrasound from Konica Minolta Medical Imaging 4Cannabiz Mobile Analyst Brief: Next Big Thing by Torus IR Issued by BrokerBank Securities, Inc. 2Perspective of Diabetes Patient Groups on the Corporate Reputation of Pharma in 2014: 130 patient groups with an interest in diabetes from 34 countries 2Perspective of Diabetes Patient Groups on the Corporate Reputation of Pharma in 2014: 130 patient groups with an interest in diabetes from 34 countries 3Perspective of Diabetes Patient Groups on the Corporate Reputation of Pharma in 2014: 130 patient groups with an interest in diabetes from 34 countries 4Perspective of Diabetes Patient Groups on the Corporate Reputation of Pharma in 2014: 130 patient groups with an interest in diabetes from 34 countries 5
... Montenegro, Serbia,... -- BOZEN, Sud-Tirol, Italy, October 11, 2010 ... ... --> ... { var s = ,; var first_result; // Results are keyed by longUrl, so we need ...
... MONTGOMERY, Ala., Oct. 11 Health Care Systems, ... 4, is 2011/2012 compliant and was certified as ... Commission for Health Information Technology (CCHIT®), an ONC-ATCB, ... adopted by the Secretary of Health and Human ...
Cached Medicine Technology:Health Robotics Expands Operations Into Bosnia, Croatia, Finland, Macedonia, Montenegro, Serbia, and Slovenia 2Health Robotics Expands Operations Into Bosnia, Croatia, Finland, Macedonia, Montenegro, Serbia, and Slovenia 3Health Robotics Expands Operations Into Bosnia, Croatia, Finland, Macedonia, Montenegro, Serbia, and Slovenia 4Health Robotics Expands Operations Into Bosnia, Croatia, Finland, Macedonia, Montenegro, Serbia, and Slovenia 5Health Robotics Expands Operations Into Bosnia, Croatia, Finland, Macedonia, Montenegro, Serbia, and Slovenia 6Health Robotics Expands Operations Into Bosnia, Croatia, Finland, Macedonia, Montenegro, Serbia, and Slovenia 7Health Robotics Expands Operations Into Bosnia, Croatia, Finland, Macedonia, Montenegro, Serbia, and Slovenia 8Health Care Systems, Inc.'s HCS eMR Receives ONC-ATCB 2011/2012 Certification 2Health Care Systems, Inc.'s HCS eMR Receives ONC-ATCB 2011/2012 Certification 3Health Care Systems, Inc.'s HCS eMR Receives ONC-ATCB 2011/2012 Certification 4
... AccuGENE Molecular Biology Buffers are ready-to-use ... molecular biology applications. Each reagent is prepared ... 0.2 micron filter, and filled into sterile ... strict quality control standards to ensure lot-to-lot ...
1.2% Tryptone, 2.4% Yeast Extract, 0.4% Glycerol, with 100ml of 10x Phosphate buffer supplement (0190-01)....
1.0% Casein digest (NZ amine), 0.5% Sodium Chloride....
S.O.C. Medium...
Medicine Products: