Navigation Links
Study could lead to 'liquid biopsy' tests for bladder cancer
Date:1/22/2014

MAYWOOD, Il. Findings from a Loyola University Medical Center study ultimately could lead to tests to screen for and diagnose bladder cancer.

Bladder cancer is the fourth most common non-skin cancer. But there is no good screening test for it, and there has been limited progress in characterizing how aggressive an individual's bladder cancer will be.

Loyola researchers studied microscopic droplets, called exosomes, that are shed by cancer cells and are found in urine. Understanding the biology of exosomes could lead to the development of a screening test, which would require a simple urine sample, said lead researcher Gopal Gupta, MD.

Exosomes derived from a urine sample also might help a physician determine how aggressive the cancer is. This, in turn, could better inform treatment decisions. The test would, in effect, serve as a "liquid biopsy," Gupta said.

The study by Gupta and colleagues is published in the peer-reviewed, open-access journal BioMed Research International.

Bladder cancer has been steadily increasing, with little progress in detection and risk stratification. Patients face significant risks of recurrence and progression. Thus, there's an urgent need to identify biomarkers of bladder cancer and the mechanisms by which bladder cancer progresses.

Exosomes are about 30 to 100 nanometers across. (A nanometer is one billionth of a meter). Exosomes contain proteins and the genetic material messenger RNA and micro RNA. RNA is a marker for genes that get expressed (turned on).

Exosomes are shed by cancer cells. In turn, they are taken up by neighboring cells or by other bladder cancer cells.

Researchers used a novel method called image cytometry to quantify how exosomes are taken up by cells. The study demonstrated how exosomes and their cargo can be transferred between cells. This supports the researchers' hypothesis that shedding of exosomes from bladder tumors plays a k
'/>"/>

Contact: Jim Ritter
jritter@luc.edu
708-216-2445
Loyola University Health System
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New study examines patterns of cancer screening in Appalachian women
2. Regenstrief, IU study: Half of hospitalized adults over 65 need surrogate decision-makers
3. Study: Possible new druggable target in Ewings Sarcoma
4. Miriam Hospital study links intimate partner violence and risk of HIV
5. Study reveals how ecstasy acts on the brain and hints at therapeutic uses
6. Study finds troubling relationship between drinking and PTSD symptoms in college students
7. China Laser Equipment Industry Production Capacity to Be 2.77 Times More by 2017 in a New Study at MarketReportsChina.com
8. Study questions anti-cancer mechanisms of drug tested in clinical trials
9. Viral microRNAs responsible for causing AIDS-related cancer, new USC study shows
10. Nashville’s Sulphur Dell Neighborhood Selected As Study Area For 2014 Urban Land Institute Gerald D. Hines Student Urban Design Competition
11. Tweaking MRI to track creatine may spot heart problems earlier, Penn Medicine study suggests
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/21/2014)... Riverdale, NJ (PRWEB) July 22, 2014 On ... 7th Annual Charity Golf Outing honoring Mike McGuriman-Motorola Solutions at ... NJ. The outing begins with registration and lunch at 11 ... lunch, dinner and prizes. Price increases to $250 after ... dinner tickets for $100 per person. The dinner will ...
(Date:7/21/2014)... As reported by CBS Local Pittsburgh in ... Addiction Awareness (7/15), thrill-seeking participants raised $100,000 to raise ... in Downtown Philly. 100 people, including some well-known local ... Convention Center Hotel. Some of the participants shared stories ... because his son killed himself after a long battle ...
(Date:7/21/2014)... 2014 The League of Voluntary Hospitals ... Healthcare Workers East (“1199SEIU”) today announced a new tentative ... healthcare providers and their employees. , Under the ... by League and 1199SEIU members, employee wages will rise ... existing worker benefits, including healthcare coverage with no out ...
(Date:7/21/2014)... 2014 Ticket Down is a ... at the Sun Life Stadium in Miami Gardens, Florida on ... Brazil and Argentina is one that has been going on ... are forming with each passing day. One rivalry that will ... and another South American nation, Colombia. The two teams saw ...
(Date:7/21/2014)... Ticket Down is a reliable source for cheap LA ... One of the best club teams in the world of football, ... Champions Cup, which is set to begin later this month across ... get a chance to fine tune their lineup for the tournament ... the Chevrolet Cup where they will take on the L.A. Galaxy ...
Breaking Medicine News(10 mins):Health News:7th Annual Push to Walk Golf Outing to Be Held September 22nd 2Health News:100 People Climb Down Building to Raise Drug Addiction Awareness in Philadelphia 2Health News:100 People Climb Down Building to Raise Drug Addiction Awareness in Philadelphia 3Health News:League of Voluntary Hospitals and Homes and 1199SEIU Reach New Four-Year Collective Bargaining Agreement 2Health News:League of Voluntary Hospitals and Homes and 1199SEIU Reach New Four-Year Collective Bargaining Agreement 3Health News:Brazil vs. Colombia Tickets in Miami: Ticket Down Reports Huge Demand for Colombia vs. Brazil Tickets at Sun Life Stadium in Miami in Early September 2Health News:Brazil vs. Colombia Tickets in Miami: Ticket Down Reports Huge Demand for Colombia vs. Brazil Tickets at Sun Life Stadium in Miami in Early September 3Health News:LA Galaxy vs. Manchester United Tickets Rose Bowl: Ticket Down Cuts Chevrolet FC Cup Ticket Prices For ManU vs. LA Galaxy in Pasadena on July 23rd 2Health News:LA Galaxy vs. Manchester United Tickets Rose Bowl: Ticket Down Cuts Chevrolet FC Cup Ticket Prices For ManU vs. LA Galaxy in Pasadena on July 23rd 3
... for patients in just the first six months after they ... in Canada, according to a study presented today at the ... Ischemic Stroke (BURST) study found that the direct and indirect ... in the six-month period following a new stroke. There are ...
... June 8, 2010The new Center for Medicare and Medicaid ... and implementing payment initiatives, continuously monitor their impact, and ... in order to realize the potential for improved health ... Health Affairs article by Commonwealth Fund researchers. ...
... (June 7, 2010) Researchers from the BC Centre ... British Columbia today released a comprehensive study revealing that ... would create significant benefits for individuals infected with HIV ... modeling study, published in the research journal PLoS ...
... at Purdue University have developed a potential new tool ... and crime-scene forensics. The technique uses a combination ... tiny particles, such as bacteria, viruses and DNA, which ... either light or electric fields separately are able to ...
... target cancerous plasma cells appears promising in treating multiple myeloma, ... at the drug elotuzumab, an antibody which is designed to ... cells. The antibody has the potential to attach to malignant ... early stage trial combined elotuzumab with bortezomib, or Velcade, one ...
... common in younger men, and it,s often more aggressive in ... of Michigan Comprehensive Cancer Center has found that a series ... cancer. Researchers believe that genetics and traditional screening methods ... cancer in younger men. "This is a potential ...
Cached Medicine News:Health News:Cost of caring for stroke patients double that of earlier estimates 2Health News:Cost of caring for stroke patients double that of earlier estimates 3Health News:Center for Medicare and Medicaid Innovation must implement payment reforms rapidly 2Health News:Center for Medicare and Medicaid Innovation must implement payment reforms rapidly 3Health News:Updated HIV therapy guidelines would reduce risk of transmission, save lives, billions in costs 2Health News:Updated HIV therapy guidelines would reduce risk of transmission, save lives, billions in costs 3Health News:New method manipulates particles for sensors, crime scene testing 2Health News:New method manipulates particles for sensors, crime scene testing 3
(Date:7/21/2014)... -- UBM Medica US announces that ConsultantLive ... primary care clinicians offers a photo collection with authoritative ... a variety of summer scourges.  The ... of medical menaces: poison ivy, tick-borne infections, insect bites, ... covered on Consultantlive,s topic center that includes sun and ...
(Date:7/21/2014)... CORONA, Calif. , July 21, 2014 /PRNewswire/ ... a leader in automated retailing, micro-stores, custom vending ... interest in their automated medicine dispensing systems, which ... alternative heath clinics and marijuana dispensaries. AVT,s newly ... secure storage of medicines and regulated products. ...
(Date:7/21/2014)... 2014  Zacks.com announces the list of stocks featured in ... discuss the latest news and events impacting stocks and the ... Pharmaceuticals, Inc. (Nasdaq: ANTH - Free Report ), Amgen, ... and Company (NYSE: LLY - Free Report ), Actelion ... (Nasdaq: ITMN - Free Report ). Today, ...
Breaking Medicine Technology:ConsultantLive Presents Special Coverage of Summer Scourges 2ConsultantLive Presents Special Coverage of Summer Scourges 3Technology Driving Cannabis Industry 2The Zacks Analyst Blog Highlights: Anthera Pharmaceuticals, Amgen, Eli Lilly, Actelion and InterMune 2The Zacks Analyst Blog Highlights: Anthera Pharmaceuticals, Amgen, Eli Lilly, Actelion and InterMune 3The Zacks Analyst Blog Highlights: Anthera Pharmaceuticals, Amgen, Eli Lilly, Actelion and InterMune 4The Zacks Analyst Blog Highlights: Anthera Pharmaceuticals, Amgen, Eli Lilly, Actelion and InterMune 5The Zacks Analyst Blog Highlights: Anthera Pharmaceuticals, Amgen, Eli Lilly, Actelion and InterMune 6The Zacks Analyst Blog Highlights: Anthera Pharmaceuticals, Amgen, Eli Lilly, Actelion and InterMune 7
... The TandemHeart circulatory support system has been granted ... Contractor (MAC) serving over 1.3 million beneficiaries and over ... United States. "We are extremely pleased with ... TandemHeart system," said  Kraig McEwen, President and CEO of ...
... July 12, 2011 Projects In Knowledge ( www.projectsinknowledge.com ... information tools for busy clinicians, has just launched its ... offered online and soon as a free iPhone/iPad ... complexities of magnetic resonance imaging (MRI) and other imaging ...
Cached Medicine Technology:TandemHeart Approved for Expanded Reimbursement 2MedImage Cases™: A New Medical e-Textbook from Projects In Knowledge® 2MedImage Cases™: A New Medical e-Textbook from Projects In Knowledge® 3
... base with vacuum stage, porous vacuum plate, reservoir ... instructions. The Model 785 vacuum blotter quickly ... agarose gel onto a nylon membrane. Because it ... nucleic acid samples can be separated on a ...
... regulator. The Model 785 vacuum blotter ... from an agarose gel onto a nylon ... min for transfer, the nucleic acid samples ... to a membrane, and the hybridization reaction ...
Inquire...
... proven electrophoretic transfer apparatus incorporating state-of-the-art plate electrodes ... allows for a very close positioning of the ... power source such as a battery charger, creates ... exceptionally rapid and exact electrophoretic transfer. ...
Medicine Products: