Navigation Links
Study could lead to 'liquid biopsy' tests for bladder cancer

MAYWOOD, Il. Findings from a Loyola University Medical Center study ultimately could lead to tests to screen for and diagnose bladder cancer.

Bladder cancer is the fourth most common non-skin cancer. But there is no good screening test for it, and there has been limited progress in characterizing how aggressive an individual's bladder cancer will be.

Loyola researchers studied microscopic droplets, called exosomes, that are shed by cancer cells and are found in urine. Understanding the biology of exosomes could lead to the development of a screening test, which would require a simple urine sample, said lead researcher Gopal Gupta, MD.

Exosomes derived from a urine sample also might help a physician determine how aggressive the cancer is. This, in turn, could better inform treatment decisions. The test would, in effect, serve as a "liquid biopsy," Gupta said.

The study by Gupta and colleagues is published in the peer-reviewed, open-access journal BioMed Research International.

Bladder cancer has been steadily increasing, with little progress in detection and risk stratification. Patients face significant risks of recurrence and progression. Thus, there's an urgent need to identify biomarkers of bladder cancer and the mechanisms by which bladder cancer progresses.

Exosomes are about 30 to 100 nanometers across. (A nanometer is one billionth of a meter). Exosomes contain proteins and the genetic material messenger RNA and micro RNA. RNA is a marker for genes that get expressed (turned on).

Exosomes are shed by cancer cells. In turn, they are taken up by neighboring cells or by other bladder cancer cells.

Researchers used a novel method called image cytometry to quantify how exosomes are taken up by cells. The study demonstrated how exosomes and their cargo can be transferred between cells. This supports the researchers' hypothesis that shedding of exosomes from bladder tumors plays a key role in the spread of the cancer.

Characterizing how exosomes are taken up and internalized by bladder cancer cells "could become invaluable for understanding the role of exosomes on bladder cancer recurrence and progression," the authors wrote.


Contact: Jim Ritter
Loyola University Health System

Related medicine news :

1. New study examines patterns of cancer screening in Appalachian women
2. Regenstrief, IU study: Half of hospitalized adults over 65 need surrogate decision-makers
3. Study: Possible new druggable target in Ewings Sarcoma
4. Miriam Hospital study links intimate partner violence and risk of HIV
5. Study reveals how ecstasy acts on the brain and hints at therapeutic uses
6. Study finds troubling relationship between drinking and PTSD symptoms in college students
7. China Laser Equipment Industry Production Capacity to Be 2.77 Times More by 2017 in a New Study at
8. Study questions anti-cancer mechanisms of drug tested in clinical trials
9. Viral microRNAs responsible for causing AIDS-related cancer, new USC study shows
10. Nashville’s Sulphur Dell Neighborhood Selected As Study Area For 2014 Urban Land Institute Gerald D. Hines Student Urban Design Competition
11. Tweaking MRI to track creatine may spot heart problems earlier, Penn Medicine study suggests
Post Your Comments:
(Date:11/25/2015)... ... November 25, 2015 , ... The McHenry County law ... successful appellate decision obtained by Attorneys Francisco J. Botto and Alex C. Wimmer. Attorneys ... Workers’ Compensation Comm’n, 2015 IL App (2d) 130884WC. , According to court documents, Adcock ...
(Date:11/25/2015)... ... November 25, 2015 , ... SCOTTSDALE, AZ) - Today, ... in both surgical and non-surgical treatments, announced the expansion of his private practice ... Surgery. , Highly trained and nationally recognized for his natural approach, Dr. ...
(Date:11/25/2015)... MI (PRWEB) , ... November 25, 2015 , ... In ... Presence Resurrection Medical Center (RMC) in Chicago, IL, UV Angel is evaluating the efficacy ... medical and surgical intensive care units (totaling 30 beds) from May 2014 through October ...
(Date:11/25/2015)... Missouri (PRWEB) , ... November 25, 2015 , ... ... HEAL, will provide scholarships for people struggling with eating disorders as a result ... from the second annual event, held at Fox Run Golf Club in Eureka, ...
(Date:11/25/2015)... ... 2015 , ... Privately owned Contract Development and Manufacturing Organization ... current state of the art research, development and manufacturing facility outside of Fort ... capacity as well as to support its clients’ growing research and development and ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... , November 26, 2015 ... addition of the "2016 Future Horizons ... of Abuse Testing Market: Supplier Shares, Country ... report to their offering. --> ... the "2016 Future Horizons and Growth ...
(Date:11/26/2015)... ) has ... Future Horizons and Growth Strategies in the ... Shares, Country Segment Forecasts, Competitive Intelligence, Emerging ... --> ) has announced the ... and Growth Strategies in the German Drugs ...
(Date:11/26/2015)... -- Research and Markets ( ) has announced ... by Type (Dressings, Therapy Devices, Active Wound Care), Application ... and Geography - Global Forecast to 2020" report ... --> The purpose of this report is ... global advanced wound care market. It involves deep dive ...
Breaking Medicine Technology: