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Study could help improve gene therapy for heart disease, cancer
Date:10/12/2011

he parasite that causes malaria. Here, the inflammatory immune response has the beneficial effect of revving up the immune system to attack germs.

The Loyola study provides new insights into how the adenovirus triggers an immune response. The study involved immune cells from humans and mice. Researchers discovered how cells sense the adenovirus as it enters a cell. This recognition, in turn, triggers the immune response. The finding could help researchers tailor the adenovirus so that it causes less of an immune response in gene therapy applications and an enhanced immune response in vaccines.

"These results will help with future studies of innate immune responses to adenovirus," Wiethoff and colleagues wrote. "Additionally, our understanding of this process could allow us to either enhance or attenuate [weaken] the innate immune response to adenovirus to generate novel vectors for gene therapy and vaccination."


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Contact: Jim Ritter
jritter@lumc.edu
708-216-2445
Loyola University Health System
Source:Eurekalert

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