Navigation Links
Study could aid development of new drugs to treat gout
Date:3/19/2013

MAYWOOD, Ill. Findings from a Loyola University Chicago Stritch School of Medicine study could lead to the development of new drugs to treat gout.

The study, led by Liang Qiao, MD, and his colleagues and collaborators, was published March 19 in the journal Nature Communications.

Gout is caused by a buildup of uric acid around joints, typically the big toe, knee or ankles. The immune system revs up to attack uric acid salt crystals, and this immune response causes painful inflammation.

The innate immune response is mainly activated by calcium that enters a macrophage immune cell through an opening called the calcium channel. There are several types of calcium channels. Researchers found that a particular type of calcium channel, called TRPM2, is responsible for initiating the immune response. (TRPM2 stands for transient receptor potential melastatin 2.)

In lab mice, study collaborators from Japan knocked out a gene that is responsible for this calcium channel. Qiao's team then exposed these "knockout" mice and a comparison group of normal mice to uric acid salt crystals and to a liposome, a compound that also causes inflammation. They found that inflammation was significantly lower in the knockout mice that lacked the TRPM2 calcium channel. They therefore concluded that disabling the TRPM2 calcium channel could be key to reducing painful inflammation from gout.

The next step will be to design a compound that would block the TRPM2 calcium channel, and then test how well this compound reduces inflammation in an animal model.

The study's findings might also apply to Alzheimer's disease and arteriosclerosis (hardening of the arteries). These two diseases, like gout, have been linked to inflammation. And it is possible that the TRPM2 calcium channel may be key to initiating the inflammatory response in these two diseases as well. But this has not been proven yet, Qiao said.

The study also could ai
'/>"/>

Contact: Jim Ritter
jritter@lumc.edu
708-216-2445
Loyola University Health System
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Study Suggests Vaccine May Help Kids With Brain Cancer
2. Study reveals how cancer drug causes diabetic-like state
3. Coffee Drinking in Pregnancy Wont Lead to Sleepless Baby: Study
4. Lower GI problems plague many with rheumatoid arthritis, Mayo Clinic study finds
5. Veggies Like Broccoli, Cabbage May Help Fight Breast Cancer: Study
6. No Added Cancer Risk From Hip Replacement Materials: Study
7. Reported Decline in U.S. Pneumonia Deaths May Be False: Study
8. Early Study Finds Some Promise for Lung Cancer Vaccine
9. Narcissists Often Ace Job Interviews, Study Finds
10. Sexual objectification of female artists in music videos exists regardless of race, MU study finds
11. Soy may alleviate hot flashes in menopause, large-scale study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/2/2015)... ANT Wireless, proven innovator in ultra-low ... two new products implementing the ANT+ Fitness Equipment Control ... interoperability in their bike trainer products, built to create ... implemented the FE-C device profile in its Vortex Smart ... new indoor training software, while Kinomap has added FE-C ...
(Date:6/2/2015)... Acara Partners has seen a spike in demand for ... as is now required by recent Google search algorithm changes. ... several new clients in the medical aesthetics vertical, are anxious ... meet Google’s new requirements,” commented Fran Acunzo, CEO of Acara ... education, non-profits, and the business world.” , Back in ...
(Date:6/2/2015)... 2015 Though almost the entire Park family ... the disease rule their lives. Organizing and hosting the June ... living life to the fullest and spreading awareness of HHT. ... but I won't live my life in a bubble because ... you'd want is to look back on your life with ...
(Date:6/2/2015)... BC (PRWEB) June 02, 2015 ... report by iData Research ( http://www.idataresearch.com ), the ... and demineralized bone matrices (DBM) over traditional allograft ... two incisions and thus an increase in operation ... The strong market growth in these synthetic materials ...
(Date:6/2/2015)... Williamsport, PA (PRWEB) June 02, 2015 ... Survey indicate that while there has been a ... (e-cigarettes) has tripled and waterpipe vapor (hookah) usage has ... Health Pediatrician Dr. Russell Gombosi believes the national ... that it could take 15 to 20 years to ...
Breaking Medicine News(10 mins):Health News:First ANT FE-C Enabled Fitness Products Enter Market 2Health News:First ANT FE-C Enabled Fitness Products Enter Market 3Health News:Acara Partners Expands Website and Digital Offerings 2Health News:Family brings awareness to genetic disease at first Memphis walk 2Health News:Medtronic, DePuy Synthes Shift U.S. Bone Graft Substitute Market Towards Synthetic Demineralized Bone Matrices 2Health News:Medtronic, DePuy Synthes Shift U.S. Bone Graft Substitute Market Towards Synthetic Demineralized Bone Matrices 3Health News:Susquehanna Health Pediatrician Warns of Adverse Effects of Teen E-Cigarette Usage 2Health News:Susquehanna Health Pediatrician Warns of Adverse Effects of Teen E-Cigarette Usage 3
... More and ... Milk Their Diets, BIRMINGHAM, Ala., Aug. 22 The ... -- which seem to go in,and out of fashion like shoulder pads and ... 25 percent of,Alabama residents -- remain overweight or obese., A new campaign ...
... to Lead Effort to End Malaria Deaths, NEW ... to raise awareness and galvanize support to address the ... Case to the,post of Chief Executive Officer, effective immediately. ... of Malaria No More in December 2006,has served as ...
... 22 Corbett Accel Healthcare Group (CAHG),is proud ... Executive Vice,President, Interactive Marketing & eInnovation, Corbett Accel ... become a member of the Executive,Leadership Team of ... a,leading digital interactive communications agency. Melick is based ...
... -, FREMONT, Calif., Aug. 22 Vermillion, ... announced the publication,of data supporting its peripheral artery ... the August, 2008 issue of the peer-reviewed,journal, Vascular ... MD, PhD,Professor of Medicine at Stanford University and ...
... launch the most sophisticated mission ever to investigate the ... of our planet the geoid - with unprecedented ... Ocean Circulation Explorer (GOCE) will be placed onto a ... vehicle launched from the Plesetsk Cosmodrome in Northern Russia, ...
... of cancer-causing compounds , , FRIDAY, Aug. 22 (HealthDay News) ... too, without producing harmful cancer-causing compounds, new research shows. ... antioxidant-rich spice blends can reduce the risk of these ... , "If you are concerned about carcinogens, marinating a ...
Cached Medicine News:Health News:Message to Birmingham Residents: Forgo Fad Dieting and Join the Campaign for Healthy Weight 2Health News:Message to Birmingham Residents: Forgo Fad Dieting and Join the Campaign for Healthy Weight 3Health News:Malaria No More Names Scott Case Chief Executive Officer 2Health News:Corbett Accel Healthcare Group Announces Promotion of Geoff Melick to Executive Vice President, Interactive Marketing & eInnovation 2Health News:Vermillion Announces Publication of Data Supporting Its Peripheral Artery Disease Diagnostic Test Program 2Health News:Vermillion Announces Publication of Data Supporting Its Peripheral Artery Disease Diagnostic Test Program 3Health News:GOCE Earth explorer satellite to look at the Earth's surface and core 2Health News:Marinades Help Keep Grilled Meat Safe 2Health News:Marinades Help Keep Grilled Meat Safe 3
(Date:6/2/2015)... ORLANDO, Fla. , June 2, 2015  One ... Master of Science in Nurse Anesthesia (MSNA) graduates of ... on their first attempt. The graduating class was composed ... 20, 2015.  The NCE is required ... Registered Nurse Anesthetist, and graduates of the MSNA program ...
(Date:6/2/2015)... June 2, 2015 ANI Pharmaceuticals, Inc. ("ANI") ... received approval from the U.S. Food and Drug Administration ... Oxycodone Hydrochloride Oral Solution 5mg/5mL. Trailing twelve-month sales for ... three current competitors. ANI expects to begin shipping to ... , President and CEO of ANI Pharmaceuticals, stated, "This ...
(Date:6/2/2015)... San MediTech, the industry leader in ... for diabetics, announced its plan to attend the American ... Boston on June 5 th to ... Monitoring System (DGMS). The company plans to show industry ... technologies and advancements made by Chinese medical device companies. ...
Breaking Medicine Technology:ADU's Master of Science in Nurse Anesthesia April 2015 Graduates Earn 100 Percent First Time Pass Rate on National Certification Examination 2ANI Pharmaceuticals Announces FDA Approval of Oxycodone Hydrochloride Oral Solution 5mg/5mL 2ANI Pharmaceuticals Announces FDA Approval of Oxycodone Hydrochloride Oral Solution 5mg/5mL 3San MediTech Showcases Smart Glucose Management Cloud Database at 75th ADA 2San MediTech Showcases Smart Glucose Management Cloud Database at 75th ADA 3San MediTech Showcases Smart Glucose Management Cloud Database at 75th ADA 4
... Dec. 17 A leading cancer physician and,researcher ... network specializing in Phase I - Phase IV ... trial conducted to,increase pathologic complete response (pCR) and ... subsequent pCR for patients with,stage 2 and 3 ...
... SuperGen, Inc.,(Nasdaq: SUPG ) today ... in a multi-arm Phase 1b clinical trial ... inhibitor (TKI). The trial will evaluate,MP470 in ... regimens,including carboplatin/paclitaxel, carboplatin/etoposide, docetaxel,topotecan, and erlotinib. The ...
Cached Medicine Technology:US Oncology Research Network Presents Clinical Studies at San Antonio Breast Cancer Symposium 2US Oncology Research Network Presents Clinical Studies at San Antonio Breast Cancer Symposium 3US Oncology Research Network Presents Clinical Studies at San Antonio Breast Cancer Symposium 4SuperGen Reports Initiation of Multi-arm Phase 1b Trial of Novel Tyrosine Kinase Inhibitor 2SuperGen Reports Initiation of Multi-arm Phase 1b Trial of Novel Tyrosine Kinase Inhibitor 3
Round handle dull finish. For right handed surgeon....
Specially designed wider jaws to help split soft nucleus, cross action, round handle, maximum opening 2.8 mm....
Irrigating nucleus chopper, tip angled 30 to side wedge shaped inferior edge with blunt tip and front notch for engaging iris end opening, 19 gauge. For use in the right hand....
Irrigating nucleus chopper, 0.6 mm dual sideports, 20 gauge. For the right handed surgeon....
Medicine Products: