In a study to be presented on February 16 between 8 a.m., and 10 a.m. PST, at the Society for Maternal-Fetal Medicine's annual meeting, The Pregnancy Meeting , in San Francisco, researchers will report findings that suggest women whose babies are small-for-gestational-age (SGA) in their first pregnancy have a strongly increased risk for SGA in a second pregnancy.
The aim of this study was to assess and describe in detail the incidence of SGA infants and the SGA recurrence rate in general. Additionally, it sought to assess the incidence and recurrence rate of SGA in women with and without a hypertensive disorder in their first pregnancy.
Infants who are small for gestational age (birth weight below the fifth percentile) are a heterogeneous group comprised of infants that have failed to achieve their growth potential (fetal growth restriction; FGR) and infants who are constitutionally small. SGA infants are at increased risk for perinatal mortality and adverse perinatal and health outcomes later in life.
"The main strength of this study was the size and composition of the cohort," said B J Voskamp, MD. "Data were derived from a large, well-maintained, population-based national perinatal registry."
The study was performed in a prospective nationwide cohort with the use of the Netherlands Perinatal Registry (PRN). The PRN consists of population-based data that includes information on pregnancy and delivery of 96 percent of pregnancies in the Netherlands. From this, they studied a cohort of women who delivered two subsequent singleton pregnancies (first and second deliveries) in the Netherlands from Jan. 1, 1999, through Dec. 31, 2007.
The primary outcome measure was SGA. Researchers registered demographic and obstetric characteristics including maternal age, parity, ethnicity, and socioeconomic status (SES).
Cases were analyzed in total and stratified into two groups: women with and without a hypertensive disor
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Society for Maternal-Fetal Medicine