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Study confirms males and females have at least 1 thing in common: Upregulating X
Date:10/24/2011

rs have not supported the idea that X chromosomes up-regulate.

Lieb and his colleagues re-analyzed data used in previous analyses, along with new data from humans, mice, roundworms, and fruit flies and found more evidence that the up-regulation hypothesis is correct but with some interesting twists across species. In mammals humans and mice both males and females up-regulate X chromosome gene expression and females then equalize expression by turning off the one X chromosome. In roundworms (C. elegans) the both female X chromosomes stay active, but the genes on both Xs are down-regulated by half to compensate in the females. In fruit files (Drosophilia melanogaster), males increase the expression of X chromosome genes, with no upregulation of X in females.

"There are several ways to get the same result and we are seeing how the dosage-balancing mechanism works in different species," says Lieb. "We also found that not all X-linked genes are dosage compensated to the same degree adding another layer of complexity for scientists who study gene regulation."


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Contact: Ellen de Graffenreid
edegraff@med.unc.edu
919-962-3405
University of North Carolina School of Medicine
Source:Eurekalert

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