Navigation Links
Study confirms males and females have at least 1 thing in common: Upregulating X
Date:10/24/2011

Chapel Hill, NC In a study published today in the journal Nature Genetics, a group of scientists including UNC biologist Jason Lieb, PhD, present experiments supporting a longstanding hypothesis that explains how males can survive with only one copy of the X chromosome. The finding provides clarity to a hotly debated topic in science and provides biologists with more information to interpret experiments involving genetic measurements in males and females.

"The issue is important because many diseases are tied to a defect in a regulatory mechanism within the cell," said Lieb, who is also a member of UNC Lineberger Comprehensive Cancer Center.

Women have two X chromosomes, while men have one X and one Y. The lack of a 'back up' copy of the X chromosome in males contributes to many disorders that have long been observed to occur more often in males, such as hemophilia, Duchene muscular dystrophy, and certain types of color blindness. Having only one copy of X and two copies of every other chromosome also creates a more fundamental problem with any other chromosome, the gene number imbalance resulting from having only one copy would be lethal. How can males survive with only one X?

Biologists have been debating how organisms and cells manage the imbalance between X and other chromosomes for years, with the dominant theory being that both sexes up-regulate the expression of X-linked genes, essentially doubling their expression to "2X" in males and "4X" in females. Then, to correct the imbalance that now appears in females (since they have the equivalent of "4" Xs now and 2 of every other chromosome), females then 'turn off' one of the hyperactive X chromosomes, resulting in a balanced "2X" expression of those genes across both sexes.

The advent of new technology based on RNA sequencing and proteomic analysis has given scientists more accurate ways to measure gene expression, and some results published in the last few yea
'/>"/>

Contact: Ellen de Graffenreid
edegraff@med.unc.edu
919-962-3405
University of North Carolina School of Medicine
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. Breast Reconstruction Boosts Womens Emotional Well-Being: Study
2. Hockey Fistfights Rarely Cause Injuries, Study Claims
3. Mayo Clinic study: PSA test valuable in predicting biopsy need, low-risk prostate cancer
4. Study finds no correlation between primary kidney stone treatment and diabetes
5. New Animal Study Might Explain Jet Lag Differences
6. Cell Phones Dont Raise Brain Cancer Risk, Study Says
7. More Than 1 in 4 U.S. Kids Witness Violence Between Parents: Study
8. Blood-pressure-lowering drug after stroke aids recovery, study finds
9. Study highlights issues faced by friends and family of the suicidal
10. Foreclosure Crisis Threatening Americans Health: Study
11. Car Crash Injury Risk Greater for Women Drivers: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/20/2013)... comprised over 24,000 Finnish subjects and was led ... a panel of 28 genetic markers improved detection ... disease (CHD) (10-year risk ≥20%) over traditional risk ... important preventive strategy for CHD, because the current ... "The results indicate that genetic markers could be ...
(Date:5/20/2013)... May 20, 2013 BenefitMall, ... employee benefit, payroll products and services and CompuPay, ... are selected as finalists for the 2013 American Business ... of the Year category, and CompuPay is a finalist ... will ultimately be a Gold, Silver or Bronze Stevie® ...
(Date:5/20/2013)... 20, 2013 With the economic recession taking ... of coupons has seen a significant rise. Jessica Hacker proclaims ... coupons one way or the other. However, some people are ... as an ineffective measure to save money. Therefore, in order ... masses about its use, the online classes offered by Jessica ...
(Date:5/20/2013)... (PRWEB) May 20, 2013 Dr. Fanny J ... Brilliant, a gentle fractional laser treatment clinically proven to fight ... Clear + Brilliant are designed to prevent and ... + Brilliant can visibly illuminate skin tone, renew and smoothen ... skin, and reduce the appearance of pores. Developed by the ...
(Date:5/20/2013)... SUNDAY, May 19 (HealthDay News) -- Sleep apnea, the ... and subconsciously waking them up, becomes more common as ... possibility that it may somehow cause -- or be ... just yet if you have sleep apnea. The research ... no connection between the two conditions. Still, scientists found ...
Breaking Medicine News(10 mins):Health News:BenefitMall And CompuPay, Inc., A BenefitMall Company, Named As Finalists In 2013 American Business Awards 2Health News:BenefitMall And CompuPay, Inc., A BenefitMall Company, Named As Finalists In 2013 American Business Awards 3Health News:Online Couponing Classes Offered by Jessica Hacker to Save Hundreds of Dollars 2Health News:Delaware Dermatologist Now Offers Clear + Brilliant Gentle Laser Skin Rejuvenation Treatments 2Health News:Sleep Apnea in Seniors Tied to Alzheimer's in Study 2Health News:Sleep Apnea in Seniors Tied to Alzheimer's in Study 3
... The following was,released today by the Democratic National ... cash in Saint Louis today,56,900 uninsured children in Missouri ... will finally say whether he supports,President Bush,s threat to ... week, President Bush is expected to veto a Democratic ...
... that typically fight bacteria, study finds , MONDAY, Oct. ... urban air pollution, shuts down early immune responses in ... vulnerable to bacteria and other foreign invaders, research shows. ... with increased cardiovascular and pulmonary hospitalizations and deaths, but ...
... Team that Provided Critical Services ... to Over 1,000 in 5 ... half of the husband and wife team that makes up La ... usually focus their attention on the dental needs of their North,County ...
... 1 Consumers are more concerned than ever,about the products ... is now more than just an every day routine, it ... Pure & Natural introduces a,new line of personal care products, ... new product line delivers more than just personal,care benefits; it ...
... Mich., Oct. 1 In an effort to,communicate ... it relates to,adult and embryonic stem cell research, ... bishops have launched a monumental,internal statewide education program ... parishes., The Church,s support for adult stem ...
... Cheryl Servais, MPH, RHIA, VP of Compliance and ... for a legal health record, WAYNE, Pa., ... peak performance within Health Information Management (HIM),departments, today ... Officer, Cheryl Servais, MPH, RHIA, authored The Legal ...
Cached Medicine News:Health News:Missouri Children to Mitt Romney: Show Me Your Health Care Priorities 2Health News:San Diego Dentist Haunted by Smiles in Dominican Republic 2Health News:Pure & Natural: Introducing an Effective, Healthy Approach to Personal Care and Beyond 2Health News:Pure & Natural: Introducing an Effective, Healthy Approach to Personal Care and Beyond 3Health News:Michigan Catholic Conference Launches Massive Internal Stem Cell Education Program 2Health News:Michigan Catholic Conference Launches Massive Internal Stem Cell Education Program 3Health News:Precyse Executive Authors New Book, The Legal Health Record 2
(Date:5/17/2013)... 17, 2013  Lakeland Industries, Inc. (NASDAQ: ... for industry, healthcare and to first responders on the ... results for the fiscal 2013 fourth quarter and year ... at stock market close and will conduct a conference ... (Logo: http://photos.prnewswire.com/prnh/20120611/NY21959LOGO ) ...
(Date:5/17/2013)... -- Orexigen® Therapeutics, Inc. (Nasdaq: OREX ) today announced ... Global Healthcare Conference in New York . ... at 11 a.m. Eastern Time. To listen to the live ... Investor Relations section of the Company,s Web site at ... after the event. About Orexigen® Therapeutics Orexigen ...
(Date:5/17/2013)... May 17, 2013   Shareholder rights attorneys  at ... Pharmaceutical, Inc. (NASDAQGS: AVEO) securities has filed a complaint ... Massachusetts .  The complaint alleges that ... Exchange Act of 1934 (the "Exchange Act") between January ... (Logo: http://photos.prnewswire.com/prnh/20130103/MM36754LOGO ) ...
Breaking Medicine Technology:Lakeland Industries to Report Fiscal Fourth Quarter and Year End Financial Results and Conduct Conference Call 2Aveo Pharmaceuticals, Inc. Sued by Investor 2Aveo Pharmaceuticals, Inc. Sued by Investor 3
... ACCESS PHARMACEUTICALS, INC.,(OTC Bulletin Board: ACCP) announced ... performed by Access collaborators at two,prominent institutes ... the joint,symposium of the American Association for ... European Organization for Research and Treatment,of Cancer ...
... Cells has Potential to Yield High ... and Therapeutic Products, ST. LOUIS and RICHMOND, Calif., Oct. ... Inc.,(Nasdaq: SGMO ) announced today the publication of data ... human stem,cells. This work represents a significant advance in the ...
Cached Medicine Technology:Access Pharmaceuticals Announces Two Poster Presentations Reporting Significant Preclinical Data on ProLindac(TM) at the AACR-NCI-EORTC 'Molecular Targets and Cancer Therapeutics' Conference 2Access Pharmaceuticals Announces Two Poster Presentations Reporting Significant Preclinical Data on ProLindac(TM) at the AACR-NCI-EORTC 'Molecular Targets and Cancer Therapeutics' Conference 3Sangamo BioSciences and Sigma-Aldrich Announce Nature Biotechnology Study Demonstrating Zinc Finger Technology for Modification of Human Stem Cells 2Sangamo BioSciences and Sigma-Aldrich Announce Nature Biotechnology Study Demonstrating Zinc Finger Technology for Modification of Human Stem Cells 3Sangamo BioSciences and Sigma-Aldrich Announce Nature Biotechnology Study Demonstrating Zinc Finger Technology for Modification of Human Stem Cells 4Sangamo BioSciences and Sigma-Aldrich Announce Nature Biotechnology Study Demonstrating Zinc Finger Technology for Modification of Human Stem Cells 5
... acclaimed GT-CAPTURE digital camera photomicrographic system can ... such as Olympus, Leica, Nikon, and Zeiss, ... transferring images over the Internet easy and ... a performance-proven Nikkor lens. The system records ...
... digital camera photomicrographic system can be mounted ... Olympus, Leica, Nikon, and Zeiss, making building ... over the Internet easy and fast. Featuring ... Nikkor lens. The system records photomicrographic images ...
... Brilliant digital images with advanced ... Stepping) high density imaging technology offers ... up to 12 million output pixels ... enabling enlarged image data for documentation ...
... from Carl Zeiss developed ... microscopy expert. Not only does ... in all image formats, it ... work with the microscope and ...
Medicine Products: