Navigation Links
Study confirms early elevated HIV infection risk in some Step Study participants
Date:5/7/2012

SEATTLE A long-term follow-up analysis of participants in the Step Study, an international HIV-vaccine trial, has confirmed that certain subgroups of male study participants were at higher risk of becoming infected after receiving the experimental vaccine compared to those who received a placebo. The vaccine used in the study did not contain the HIV virus, but it did contain HIV genes which were delivered to cells using a vector that employed a type of cold virus known as adenovirus serotype 5 (Ad5).

Of the 1,836 men examined in this study, 172 became infected with HIV. Within 18 months of enrollment or one year after the last vaccination, men who had neutralizing antibodies to Ad5 or who were uncircumcised, or both, had a two- to four-fold increased risk of acquiring an HIV infection, according to findings published in the May 4 online edition issue of the Journal of Infectious Disease.

However, the study also found that the risk level waned after about 18 months to be equal to that of volunteers who received a placebo.

Why this association occurred, what the biological mechanisms were and why the risk of infection lessened with time are unknown and require more study, according to Ann Duerr, M.D., a member of the Vaccine and Infectious Disease Division of Fred Hutchinson Cancer Research Center, who led the data analysis.

"There seems to be some kind of biologic phenomena that affects infection risk," she said.

The current study indicated that self-reported risk behaviors, such as unprotected sex, did not differ significantly between the vaccine and placebo arms of the Step trial.

The research also confirmed there was no elevated risk of infection in vaccinated men who were circumcised and who were Ad 5 seronegative (men who had no neutralizing antibodies to the adenovirus vector used in the vaccine). An earlier interim analysis of the Step Study data, done after immunizations in the vaccine trial were halted in 2007, also
'/>"/>

Contact: Dean Forbes
dforbes@fhcrc.org
206-667-2896
Fred Hutchinson Cancer Research Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Despite Treatment, Employees with Depression Generate Higher Absentee Costs, According to Thomson Reuters Study
2. American Council on Exercise (ACE) Study Reveals Kettlebells Provide Powerful Workout in Short Amount of Time
3. TV drama can be more persuasive than news program, study finds
4. Study carried out into biological risks of eating reptiles
5. Neuroimaging study may pave way for effective Alzheimers treatments
6. Study finds racial gaps continue in heart disease awareness
7. Luth Researchs IndicatorEDG(TM) Study Finds Americans Hopes of Achieving Their Dreams Are Fading
8. First blinded study of venous insufficiency prevalence in MS shows promising results
9. Soothing infants with food focus of childhood obesity study
10. People with anxiety disorder less able to regulate response to negative emotions, study shows
11. American Heart Association Rapid Access Journal Report: Study Finds Racial Gaps Continue in Heart Disease Awareness, Low Knowledge of Heart Attack Warning Signs Among Women
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/13/2014)... Anson County, NC (PRWEB) July 13, 2014 ... ceremony of its newest location, the Carolinas HealthCare System ... dollar facility replaces the aged Anson Community Hospital in ... location is approximately three miles from the previous facility. ... a single-story floorplan that includes an emergency room drop-off, ...
(Date:7/13/2014)... Recently, MillionaireCasket.com, a well-known casket manufacturer from China, ... Additionally, the company’s chief executive officer has announced a new ... are offered at discounted prices, from 15 to 26 percent ... are in huge demand in the current market. We are ... have a lot of high quality products for sale. Many ...
(Date:7/13/2014)... 2014 Advanced boilers are preferred ... amount of fossil fuels, produce high-capacity power, emit ... increased global warming and climate change concerns, many ... harmful gas emissions and pollutants coming from fossilfuel-based ... the global advance boilers market., The global power ...
(Date:7/13/2014)... Serena Gordon HealthDay Reporter ... A new type of sensor for people with diabetes is ... saliva instead of blood, researchers report. Scientists at Brown ... it using artificial saliva. It uses light, metal and a ... "Everybody knows that diabetics have to prick their fingers ...
(Date:7/13/2014)... Trujillo Alto, Puerto Rico (PRWEB) July 13, 2014 ... that NBA Hall of Famer, Chris Mullin, will be ... Meeting on Saturday, July 26th in Puerto Rico. ... opportunities. Chris Mullin will participate in two exhibition basketball ... Max International, the ultimate supplier of health- and ...
Breaking Medicine News(10 mins):Health News:Carolinas HealthCare System - Anson Hospital Now Open 2Health News:Cheap Oak Caskets Recently Unveiled By China Casket Manufacturer MillionaireCasket.com 2Health News:North America Advanced Boilers Market is Expected to Reach $518.7billion by 2019 - New Report by MicroMarket Monitor 2Health News:North America Advanced Boilers Market is Expected to Reach $518.7billion by 2019 - New Report by MicroMarket Monitor 3Health News:Saliva Test Might Someday Replace Needle Prick for Diabetics 2Health News:Saliva Test Might Someday Replace Needle Prick for Diabetics 3Health News:Max International Announces NBA Dream Team Member Chris Mullin as Featured Guest of Charity Event 2Health News:Max International Announces NBA Dream Team Member Chris Mullin as Featured Guest of Charity Event 3Health News:Max International Announces NBA Dream Team Member Chris Mullin as Featured Guest of Charity Event 4
... may help diagnose heart disease, cancers, HIV and other ... clinical methods. The microsponges are an essential component of ... a new paper in the journal Small . ... Professor in Bioengineering and Chemistry, and his colleagues at ...
... the highest adolescent pregnancy and birth rate among developed countries ... pregnant do not have aspirations of going to college or ... researchers at Women & Infants Hospital of Rhode Island shows ... college and get a good job. Whether or not the ...
... Kathleen Doheny HealthDay Reporter , WEDNESDAY, Feb. 9 ... every day may be cutting down on calories, but they ... suggests. "In our study, we saw a significant increased ... regular soda," said Hannah Gardener, an epidemiologist at the University ...
... Louisville School of Medicine professors recently authored reference works ... use of radiation treatment for childhood cancers and the ... Edward C. Halperin, dean of the school, is co-author ... Dr. Kelly M. McMasters, chair of the Department of ...
... the number of brain injuries and deaths from crashes, appear ... spine injury, new research from Johns Hopkins suggests. "We ... riding a motorcycle can be detrimental during a motorcycle crash," ... professor of surgery at the Johns Hopkins University School of ...
... reliance on coastal waters for food, trade and tourism ... closely monitored to guarantee their future sustainability. ESA,s ... full advantage of the unique capabilities of the Medium ... With a resolution of 300 m, MERIS ...
Cached Medicine News:Health News:Microsponges from seaweed may save lives 2Health News:Microsponges from seaweed may save lives 3Health News:Research: Pregnant teens want to go to college, need support 2Health News:Can Diet Soda Boost Your Stroke Risk? 2Health News:Can Diet Soda Boost Your Stroke Risk? 3Health News:New works by UofL professors provide latest oncology reference guides 2Health News:Motorcycle helmets reduce spine injuries after collisions 2Health News:ESA's sharp eyes on coastal waters 2
(Date:7/11/2014)... MELBOURNE, Australia , July 11, 2014  Australian ... today announced that it has raised A$19.3 million via ... Europe , the U.S., ... and A$3 million from a share purchase plan (SPP) ... A$16.3 million will be made in two tranches. ...
(Date:7/11/2014)... 2014 Show organisers ... Health Expo 2014 were a brand new ... London , plus a 10% ...        (Logo: http://photos.prnewswire.com/prnh/20130723/629764-a) ...      (Photo: http://photos.prnewswire.com/prnh/20140711/696892-b ...
(Date:7/10/2014)...  Breg, Inc., a premier provider of sports ... knee brace with new innovations to help people, ... to active lifestyles.  FreeRunner,s patent-pending design acts on ... when patients need it most, and the ability ... Patellofemoral issues are the most common cause of ...
Breaking Medicine Technology:Phosphagenics' A$19.3 million Capital Raising 2Phosphagenics' A$19.3 million Capital Raising 3UK's Flagship Health & Safety Event Has Successful Inaugural Year in London 2UK's Flagship Health & Safety Event Has Successful Inaugural Year in London 3UK's Flagship Health & Safety Event Has Successful Inaugural Year in London 4Breg Introduces Knee Brace to Help Runners with Patellofemoral Pain Syndrome 2
... -- Golden Meditech Holdings Limited ("Golden Meditech" or ... today announced that the Group has accumulated 754,791 ordinary shares ... CO.US) from the open market between December 2010 and March ... 39.5% of the issued share capital of CCBC. ...
... Mass., June 23, 2011 SeraCare Life Sciences, Inc. (NASDAQ: ... vital products and services to facilitate the discovery, development and ... of an unsolicited offer from MSMB Capital proposing to purchase ... share. It is anticipated that the SeraCare Board of Directors ...
Cached Medicine Technology:Golden Meditech to Increase Stake in NYSE-listed Affiliate -- China Cord Blood Corporation to 39.5% 2SeraCare Acknowledges Receipt of Unsolicited Proposal from MSMB Capital 2
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: