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Study compares balanced propofol sedation with conventional sedation for therapeutic GI endoscopic procedures
Date:2/15/2011

OAK BROOK, Ill. Feb. 15, 2011 Researchers from Korea report that, compared with conventional sedation, balanced propofol sedation (BPS) using propofol in combination with midazolam and meperidine, provided higher health care provider satisfaction, better patient cooperation, and similar adverse event profiles in patients undergoing therapeutic endoscopic procedures. This is the first prospective study of BPS in direct comparison with conventional sedation. The researchers note that this study provides further evidence to support the adoption of endoscopist-directed BPS for therapeutic endoscopy. The study appears in the February issue of GIE: Gastrointestinal Endoscopy, the monthly peer-reviewed scientific journal of the American Society for Gastrointestinal Endoscopy (ASGE).

Propofol sedation for gastrointestinal (GI) endoscopy has become popular worldwide. In recent years, propofol has been used safely and effectively in advanced interventional endoscopic procedures, such as endoscopic retrograde cholangiopancreatography (ERCP) and endoscopic ultrasound (EUS), even for high risk patients. However, propofol monosedation is not risk free with interventional endoscopy, which usually entails a longer procedure time, larger doses of propofol, and potentially more frequent dose-related side effects compared with those of diagnostic endoscopies. Propofol has several disadvantages associated with its pharmacokinetic properties and therefore nonanesthesiologist-administered propofol sedation for GI endoscopy remains a highly controversial issue.

Balanced propofol sedation (BPS) combines small incremental doses of propofol with single induction doses of benzodiazepines and opioids under the direction of a physician that is not an anesthesiologist. Because BPS usually targets moderate sedation, adequate amnesia and analgesia can be achieved with concomitant administration of benzodiazepines and opioids.

"Several prospective studies
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Contact: Anne Brownsey
abrownsey@asge.org
630-570-5635
American Society for Gastrointestinal Endoscopy
Source:Eurekalert

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