Navigation Links
Study by Allegheny General Hospital Physicians Shows Oral Immunotherapy is a Safe, Effective Alternative to Allergy Shots for Ragweed Sufferers
Date:2/25/2013

Pittsburgh, PA (PRWEB) February 25, 2013

Liquid medication taken under the tongue is a safe and effective alternative to injections for ragweed allergy sufferers, according to a study presented today at the annual meeting of the American Academy of Asthma, Allergy and Immunology in San Antonio, TX.

The study is the first Phase III clinical trial to demonstrate the efficacy of liquid sublingual therapy for ragweed allergy, North America’s dominant seasonal allergy.

Deborah Gentile, MD, Director of Research in the Division of Allergy, Asthma and Immunology at Allegheny General Hospital and one of the lead authors on the study, said the results are great news for allergy patients, who could soon find weekly visits to the doctor’s office for allergy shots becoming a thing of the past.

“With sublingual immunotherapy, allergy patients can administer their own medication at their convenience, without leaving their homes,” Dr. Gentile said. “We also expect more patients will adhere to their medication regimen when no injections are involved.”

Dr. Gentile collaborated in the study with Peter S. Creticos, MD of Creticos Research Group, Crownsville, Maryland and Allergy and Asthma Specialists of Greater Washington, Warrenton, Va.; Robert Esch, Ph.D., and Brad Whitlow, BS, of Greer Laboratories, Lenoir, NC; Peter Couroux, MD, Topstone Research, Toronto, Ont; Pina D’Angelo, M.Sc., PRACS Institute, Mississauga, Ont., and Michael Alexander, MD of Niagara Clinical Research, Niagara Falls, Ont.

A successful Phase 3 clinical trial marks the final step before submitting a treatment for FDA approval, Dr. Gentile said. Phase III trials take a new treatment that has shown promising results in earlier studies of relatively small numbers of patients and compare it with the current standard of care for that disease in a larger sampling of patients.

The study looked at 429 patients ages 18-55 with ragweed-related allergic rhinoconjunctivitis who were randomly selected to receive either the maximum tolerable dose of standardized glycerinated short ragweed sublingual allergen immunotherapy liquid (RW-SAIL), or a placebo identical in taste and texture. They did not receive allergy shots, the current standard of care.

They self-administered the treatment for approximately 8-16 weeks before and through the end of the ragweed pollen season and recorded in an electronic diary their daily symptoms of rhinoconjunctivitis (nasal congestion, runny nose, post-nasal drip, sneezing, red eyes). RW-SAIL significantly improved allergy management, as patients reported a 43 percent decrease in symptoms compared with those who got the placebo. None of the subjects experienced anaphylaxis, a life-threatening allergic reaction, or needed to use epinephrine, an emergency treatment for severe allergic reactions.

Subcutaneous immunotherapy (SCIT), or injections, is the conventional mode of therapy for patients suffering from ragweed allergy. The treatment is complicated by the prolonged injection schedule, which often leads to patient noncompliance due to the frequent doctor’s office visits required, as well as discomfort and the risk of anaphylaxis.

Sublingual immunotherapy (SLIT), under the tongue drops or tablets, is widely used in Europe but not yet approved by the U.S. Food and Drug Administration. Some physicians prescribe the drug off-label to patients who are willing to pay out of pocket for the more convenient therapy.

The current study is the first prospective, confirmatory Phase III trial to demonstrate the clinical effectiveness of SLIT with liquid drops in treating ragweed allergy. The clinical improvement of 43 percent well exceeded the 20 percent that is the World Allergy Organization’s accepted norm for clinically meaningful improvement, Dr. Gentile said.

Dr. Gentile and AGH colleague David Skoner, MD, Director of AGH’s Division of Allergy, Asthma and Immunology, have been pioneers in the development of oral immunotherapy for allergy sufferers. Their studies have paved the way for this significant Phase III trial.

A study by the AGH Team that was published in 2010 by the Journal of Allergy and Clinical Immunology found that immunotherapy tablets taken by mouth were safe and effective in relieving Timothy grass allergy symptoms in children ages 5 to 17. Severity of symptoms improved by 26 percent in those who received the tablet vs. those who were randomly assigned to a placebo.

Another study, published in 2011 in the Journal of Allergy and Clinical Immunology found under-the-tongue tablets safe and effective for children and adolescents suffering from allergic rhinoconjunctivitis. And a 2012 study presented by Dr. Skoner at the annual meeting of the American Academy of Allergy, Asthma and Immunology found that under-the-tongue tablets were also effective and safe for adults suffering from allergic rhinoconjunctivitis.

At this year’s AAAAI conference, Dr. Skoner also presented the results of a nationwide survey showing that educational efforts are needed to improve patient expectations and knowledge about specific immunotherapy (SIT), which desensitizes patients to their allergens. It is one of the most effective therapies available for allergic rhinoconjunctivitis, which is one of the most common chronic diseases in the U.S.

A telephone survey of 2,765 people showed that only 32 percent had heard of SIT, and of those aware of it 65 percent had discussed it with their health care providers.

Read the full story at http://www.prweb.com/releases/2013/2/prweb10456595.htm.


'/>"/>
Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

Related medicine news :

1. Doctors Health Press Reports on Study: Heart-Healthy Linoleic Acid Levels Decrease with Age
2. Columbus Center for Women’s Health Research is participating in an International Study for a New “Use-as-Needed” Treatment for Women with Sexual Dysfunction
3. UNC-led study documents head and neck cancer molecular tumor subtypes
4. Breast Reconstruction Using Womens Own Tissue Appears Safe: Study
5. Israel rocket attacks increase miscarriage likelihood -- Ben-Gurion U. research study
6. Plastics Chemical BPA Common in Preemie ICU: Study
7. Fitness Expert Lorna Kleidman Responds to Study Claiming Exercise Can Decrease Risk of Dementia
8. Dialysis Catheters Tied to Higher Risk for Infection, Death, Study Finds
9. Should grandma join Facebook? It may give her a cognitive boost, study finds
10. Climate Change Could Affect Monarch Butterflys Migration, Study Says
11. Blood Thinners May Boost Survival for Prostate Cancer Patients: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/27/2016)... ... May 27, 2016 , ... Southland Log Homes , ... American timber frame barn kits, which can be found on its website at SouthlandLogHomes.com. ... American barn plans, and they highlight the craftsmanship of timber post and beam construction. ...
(Date:5/27/2016)... ... May 27, 2016 , ... With over 60 percent ... the demand for a sustainable product to aid in the rehabilitation process has steadily ... the recovery of individuals with hemiplegia due to stroke. , Ekso Bionics has now ...
(Date:5/27/2016)... ... ... Beleza Medspa has initiated a new program to assist active ... time that Coolsculpting is being used for for more than just cosmetic purposes. ... the prescribed body-fat standard, measured by the circumference-based tape method. The tape-test is ...
(Date:5/27/2016)... ... ... With a team of certified experts, Validation Center is ... GMP accreditation, Validation Center is also a registered authority of the international system ... Validation Center is ISO17025 accredited and only offers its clients the latest technology, ...
(Date:5/26/2016)... ... May 26, 2016 , ... Cabot ... of defective respirators, according to court documents and SEC filings. A jury ... Becky Tyler v. American Optical Corporation, Case No. BC588866, Los Angeles County, California. ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... May 25, 2016 As illustrated ... earlier this month, the numbers and momentum of cannabis ... climb into the billions, more research and development push ... Edition State of Legal Marijuana Markets Report  from from ... firm, much of the increase in sector is attributed ...
(Date:5/25/2016)... 25, 2016 ReportsnReports.com adds ... report that provides an overview on therapeutic pipeline ... various stages, therapeutics assessment by drug target, mechanism ... molecule type, along with latest updates, and featured ... players involved in the therapeutic development for Chronic ...
(Date:5/24/2016)...  Diana Russell suffers from a form of rheumatoid ... out.  This disease has put her in a wheelchair, ... grandchildren to leave her home.  Because of the size ... the wheelchair.  So if there is a family function, ... left to wait for the bus. Photo ...
Breaking Medicine Technology: