Navigation Links
Study Weighs Cost, Benefit of Gene Tests Before Warfarin Rx
Date:1/20/2009

The screens resulted in better patient outcomes but at high price, researchers say

TUESDAY, Jan. 20 (HealthDay News) -- Genetic testing isn't cost-effective in guiding initial dosing of the blood thinner warfarin in patients with atrial fibrillation (a type of abnormal heart rhythm), a University of Cincinnati study finds.

Warfarin is used to prevent blood clotting in these patients. In 2007, the U.S. Food and Drug Administration changed the labeling for warfarin to suggest that doctors consider genetic testing before using the blood thinner.

"There are certain genes that are known to contribute to an increased sensitivity to warfarin," study lead investigator Dr. Mark Eckman, professor of medicine, explained in a UC news release.

"The idea behind genetic testing -- also known as pharmacogenetic-guided dosing -- is to help guide the initial, and possibly lower, dose of warfarin for patients," Eckman said. "The hope is that more accurate dosing will translate into decreased major bleeds during the initiation phase of warfarin dosing, which is the first month or so."

He and his colleagues analyzed the findings of three published studies and then created a model to estimate the cost-effectiveness of genetic testing.

They found that genotype-guided dosing did result in better patient outcomes but at a cost of more than $170,000 per quality-adjusted life year gained. They also found that there is only a 10 percent chance that genotype-guided dosing is likely to be cost-effective. The findings were published in the Jan. 20 issue of the journal Annals of Internal Medicine.

The researchers concluded that genotype-guiding dosing is cost effective if it:

  • is used for patients at high risk for hemorrhage;
  • prevents more than 32 percent of major bleeding events;
  • is available within 24 hours;
  • costs less than $200.

"This could be accomplished if testing were done in-house, at lower cost and without delays," said Eckman. Currently, most of these tests have to be sent to outside laboratories, which can lead to increased cost and treatment delays.

More information

The U.S. Agency for Healthcare Research and Quality has more about warfarin.



-- Robert Preidt



SOURCE: University of Cincinnati, news release, Jan. 19, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Study compares 2 nonsurgical treatments for reflux disease
2. Study examines racial disparities in survival among patients diagnosed with lung cancer
3. Study shows rise in antibiotic resistant pediatric head and neck infections
4. Study: Growth in research comes at a steep price
5. National Childrens Study Begins Recruiting
6. A Study In This Months Journal Of Nervous And Mental Disease Reveals Hope For Recovery From Suicidal Thinking And Treatment Resistant Mental Illness
7. Tufts receives NIH grant to study obesity prevention in new immigrants
8. New Research From EBRI: Study Examines Issues in Capping Tax Exclusion of Health Coverage
9. 2009 Most Wired Survey and Benchmarking Study Opens Today
10. Seattle Reproductive Medicine Study Investigates Newly Formulated Medications for Luteal Support in IVF
11. Newer Antipsychotics Pose Cardiac Risk: Study
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study Weighs Cost, Benefit of Gene Tests Before  Warfarin Rx
(Date:6/23/2017)... ... , ... PureLife Dental is pleased to announce that California Dental Association (CDA) ... of the amalgam separator endorsement, all CDA members may purchase an ECO II amalgam ... value. This partnership between PureLife and CDA is especially timely as it coincides with ...
(Date:6/23/2017)... ... June 23, 2017 , ... American Farmer, will feature Chr. Hansen, Inc ... to air fourth quarter 2017. American Farmer airs Tuesdays at 8:30aET on RFD-TV. Check ... founded Chr. Hansen in Denmark in 1874 after a groundbreaking discovery of how to ...
(Date:6/23/2017)... ... June 23, 2017 , ... The ... related services to families and business owners in and around Lackawanna County, is ... senior citizens in the area. , Meals on Wheels of NEPA provides hand-delivered ...
(Date:6/23/2017)... Gilmer, TX (PRWEB) , ... June 23, 2017 , ... ... consultations to residential and business clients throughout eastern Texas, is announcing the launch of ... , Recent breast cancer statistics in the United States reveal that an estimated ...
(Date:6/23/2017)... The Woodlands, TX (PRWEB) , ... June 23, ... ... provides families and business owners in the Houston area with access to asset ... Foundation for a regional charity event aimed at improving the lives of children ...
Breaking Medicine News(10 mins):
(Date:6/5/2017)... , June 5, 2017 Kohll,s Pharmacy ... the United States . The Raizer is ... a fallen person up to an almost-standing position ... and operated by one assistant and does not ... is simple enough that a child can operate it, ...
(Date:5/30/2017)... 2017 Hill-Rom Holdings, Inc. (NYSE: HRC), will present ... Conference on Tuesday, June 13, 2017, in Rancho ... president and chief executive officer, is scheduled to present at ... can be accessed at http://ir.hill-rom.com/events.cfm . A recorded replay ... event through September 13, 2017. ...
(Date:5/24/2017)...  ivWatch LLC today announced the launch of ... enable seamless integration of ivWatch,s groundbreaking IV infiltration ... and other devices. By integrating ivWatch technology into ... health care customers deliver a higher level of ... therapy. "The ivWatch OEM Board provides ...
Breaking Medicine Technology: