Navigation Links
Study Upholds Stopping Plavix Use Before Surgery
Date:11/10/2008

Taken less than 5 days before operation leads to more bleeding, longer hospital stay, study finds

MONDAY, Nov. 10 (HealthDay News) -- Someone who has taken the clot-preventing drug Plavix less than five days before having bypass surgery runs a higher risk of excess bleeding, is more likely to require a second operation, and will spend more time in the hospital, says a study that buttresses current guidelines.

Those guidelines from the American College of Surgeons recommend discontinuing Plavix five to seven days before coronary artery bypass surgery, said Dr. Richard C. Becker, a professor of medicine in cardiology and hematology at Duke University, and co-author of a report in the Nov. 18 issue of the Journal of the American College of Cardiology.

"Those guidelines were based on data we thought could be strengthened specifically by defining what the risk of bleeding might be," Becker said. The guidelines say that bypass surgery can be done on people who have been taking Plavix, if the need for surgery is urgent, and the risk of extra bleeding is deemed acceptable.

So, Becker and his colleagues at Duke and other institutions studied 596 people who had bypass surgery at 14 hospitals for acute coronary syndromes such as heart attacks.

Major bleeding occurred in 35 percent of the 298 participants who had taken Plavix within five days of the surgery, compared to 26 percent of the 298 who had not taken the drug in that period, the researchers found.

Those who had taken Plavix were three times more likely to require a second procedure because of bleeding than those not taking the drug -- 6.4 percent versus 1.7 percent. And the average hospital stay was 9.7 days for those who took the clot-preventing medication versus 8.6 days for those who didn't.

"Those results are consistent with some prior observations," Becker said. "They added information about bleeding not only in terms of transfusions but also hospital stay and chest tube output."

Chest tube output is bleeding through the tube inserted for the bypass procedure.

The new study "is able to show that the five-day window is important," Becker said. "Every day you wait lessens the risk."

"The study has confirmed what we all suspected," said Dr. Jawahar L. Mehta, director of molecular cardiology and holder of the Stebbins Chair in Cardiology at the University of Arkansas for Medical Sciences. "I don't think there is anything in it that is upsetting. This was expected."

The risks of operating within the five-day period "have never been studied before in a systematic fashion," Mehta said.

Bypass surgery should not be performed until five days after Plavix is stopped, "unless there is an absolute emergency to operate, which is not often these days, because we have other approaches," Mehta said.

More information

Learn about the benefits and risks of taking clopidogrel from the U.S. National Library of Medicine.



SOURCES: Richard C. Becker, professor, medicine, Duke University, Durham, N.C.; Jawahar L. Mehta, director, molecular cardiology, University of Arkansas for Medical Sciences, Little Rock; Nov. 18, 2008, Journal of the American College of Cardiology


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Cornell researchers study showing evidence of a major environmental trigger for autism
2. Study confirms increased heart attack deaths in NYC ambulance diversions
3. Study improves recovery for mothers with depression
4. Companies Pay a High Price for Employees With Crohns Disease and Ulcerative Colitis, According to Study From Thomson Reuters
5. Study Finds Rise in Rate of Diagnostic Imaging in Managed Care
6. Study finds rise in rate of diagnostic imaging in managed care
7. Overnight Dialysis Saves Lives: Study
8. Superbugs on the rise in Canadian hospitals, new Queens study shows
9. First Study of War-Related Mental Disorders Among Iraqis 10 Years Post-Gulf War Published by Researchers at Wayne State University and Basrah University, Iraq
10. University of Minnesota Study Says Students Eat More Whole Grains When Gradually Added to School Foods
11. Childrens Hospital study demonstrates how bone marrow transplant can cure sickle cell disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study Upholds Stopping Plavix Use Before Surgery
(Date:1/20/2017)... ... January 20, 2017 , ... A new partnership between ... they no longer use or need, from clothes to couches to dressers and bicycles. ... and take them to the nearest Goodwill donation center through February 28th. , ...
(Date:1/20/2017)... Miami, Florida (PRWEB) , ... January 20, 2017 , ... ... in head lice cases in families with school-aged children since the holiday season. ... spend the holidays with their families, sharing hugs and taking photos, which is the ...
(Date:1/20/2017)... ... January 20, 2017 , ... ... its sugar-free alternative VW+ 002. The drinks have been produced in collaboration with ... to perform during your workout. , After a successful launch in Sweden last ...
(Date:1/20/2017)... ... 2017 , ... D R Burton Healthcare Products LLC, makers ... in a study indicating superior performance against competitive products in secretion clearance. ... Positive Expiratory Pressure Devices During Simulated Breathing“ was published in the winter issue ...
(Date:1/20/2017)... ... January 20, 2017 , ... “God's Miracle Man: Against All Odds”: an ... of published author, Keith C. A. Tucker, son of Minister Delores Pinnock and a ... by Reverend Mark Hardy , “While sitting up in bed, I felt a pounding ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... 19, 2017 Shire plc (LSE: ... U.S. Food and Drug Administration (FDA) has acknowledged receipt ... Application (NDA) for SHP465, a long-acting, triple-bead, mixed amphetamine ... once-daily treatment for Attention-Deficit/Hyperactivity Disorder (ADHD). The FDA is ... 20, 2017, the designated Prescription Drug User Fee Act ...
(Date:1/19/2017)... 19, 2017 Pfizer joins ... Milner Therapeutics Consortium   Major research ... Cambridge   The Milner Therapeutics ... ) as a partner to the Milner Therapeutics Consortium. ... the efficient transfer of materials between industry and academia ...
(Date:1/19/2017)... Florida , January 19, 2017 ... Trump administration appears serious about reducing the FDA,s ... and innovation in the medical drug industry, many ... ahead with new clinical trials and development of ... companies forging ahead with recent developments include:  Moleculin ...
Breaking Medicine Technology: