Navigation Links
Study Ties Gene to Dangerous Heart Valve Deposits
Date:2/6/2013

WEDNESDAY, Feb. 6 (HealthDay News) -- Researchers have identified a gene variant that doubles the risk of having calcium deposits on the heart's aortic valve.

Severe aortic valve calcification can cause narrowing or blockage of the aortic valve, a condition called aortic stenosis, which can prevent the proper amount of blood from reaching the brain and the rest of the body.

Researchers analyzed genetic data from thousands of people and found that a genetic variant of the LPA gene was strongly associated with having aortic valve calcification on a CT scan and increased the risk of developing aortic stenosis by more than 50 percent.

The LPA gene codes for a type of cholesterol particle called lipoprotein (a), which circulates in the blood and is associated with increased risk of heart attack. Previous studies have linked lipoprotein (a) with aortic valve disease, but this study is believed to be the first to provide evidence that it may actually play a role in the disease.

The findings, published in the Feb. 7 issue of the New England Journal of Medicine, could help explain why aortic valve calcification runs in families. It might also lead to the development of new drugs to slow the progression of the disease.

"This is an important step forward in understanding the biology of the development of aortic stenosis and how this common genetic variant, which is found in 7 percent of the general population, contributes to that risk," study senior author Dr. Wendy Post, a cardiologist and associate professor of medicine and epidemiology at the Johns Hopkins University School of Medicine in Baltimore, said in a university news release.

Non-genetic risk factors for aortic valve calcification include older age, high blood pressure, obesity, high cholesterol levels and smoking. Men are more likely than women to develop aortic valve calcification.

More information

The U.S. National Heart, Lung, and Blood Institute has more about heart valve disease.

-- Robert Preidt

SOURCE: Johns Hopkins Medicine, news release, Feb. 6, 2013


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Electrical Brain Stimulation Plus Drug Fights Depression: Study
2. Mayo Clinic-led study identifies biomarkers for early risk assessment of acute kidney injury
3. Study to test whether hearing aids can help prevent falls
4. Study identifies skiers who can be successfully treated without surgery after an ACL tear
5. Study of brain cooling and clot-busting drug therapy for stroke receives FDA OK to expand
6. Shift to Hospice Care Often Comes Too Late, Study Finds
7. Steroid Shots for Tennis Elbow Miss the Mark: Study
8. Diabetes Drug May Offer Modest Weight Loss for Very Obese Teens: Study
9. Mammogram every 2 years has same benefit as yearly mammogram for older women, UCSF study finds
10. Sunshine Linked to Lower Rheumatoid Arthritis Risk: Study
11. Patient Involvement Lowers Health Costs, Study Says
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study Ties Gene to Dangerous Heart Valve Deposits
(Date:5/27/2016)... , ... May 27, 2016 , ... Aimed at nurses ... interest stories, which come courtesy of leaders in the nursing and health care industry. ... leading advocates and associations—namely Abilene Christian University. , As the nursing industry is ...
(Date:5/26/2016)... ... ... There are many ways to cook a hot dog, but new research ... their dogs straight off the grill. Of the 90 percent of Americans who say ... a hot dog, far outpacing other cooking methods such as steaming (12 percent), microwaving ...
(Date:5/26/2016)... Atlanta, Georgia (PRWEB) , ... May 26, 2016 ... ... a certificate in intellectual property (IP) to its specialty academic programs. , Answering ... joins the college’s existing certificate programs in health law, and environmental and land ...
(Date:5/26/2016)... ... 2016 , ... Cardiac arrhythmia is a common complication following ... survival, reports a team of UPMC researchers in the largest study of its ... Thoracic and Cardiovascular Surgery, provide critical information that will hopefully lead to better ...
(Date:5/26/2016)... ... May 26, 2016 , ... Dr. James Maisel will ... Long Island Chapter on June 4, 2016, 1:30-3:30 pm at the Farmingdale Public ... Retina Group of New York , is a Board Certified ophthalmologist who ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... LAWRENCE, Mass. , May 24, 2016  NxStage ... medical technology company focused on advancing renal care, today ... Officer, plans to participate in the following schedule of ... will be made available at http://ir.nxstage.com/ . ... Jefferies Healthcare Conference NY, NY           Friday, ...
(Date:5/24/2016)... , May 24, 2016  Joe Marziani has joined VMS BioMarketing as senior ... executive officer, today. In his new role, Marziani will lead the company,s business development ... professionals to improve outcomes. Photo - http://photos.prnewswire.com/prnh/20160523/371089 ... ... ...
(Date:5/24/2016)... 2016 Los innovadores de ... mundo, introduce catéteres para la intervención de extremidades ... compañía global especializada en el suministro de soluciones ... cartera incluyendo productos para tratar la enfermedad arterial ... son los dispositivos de primera entrada de la ...
Breaking Medicine Technology: