Navigation Links
Study Ties Gene to Dangerous Heart Valve Deposits
Date:2/6/2013

WEDNESDAY, Feb. 6 (HealthDay News) -- Researchers have identified a gene variant that doubles the risk of having calcium deposits on the heart's aortic valve.

Severe aortic valve calcification can cause narrowing or blockage of the aortic valve, a condition called aortic stenosis, which can prevent the proper amount of blood from reaching the brain and the rest of the body.

Researchers analyzed genetic data from thousands of people and found that a genetic variant of the LPA gene was strongly associated with having aortic valve calcification on a CT scan and increased the risk of developing aortic stenosis by more than 50 percent.

The LPA gene codes for a type of cholesterol particle called lipoprotein (a), which circulates in the blood and is associated with increased risk of heart attack. Previous studies have linked lipoprotein (a) with aortic valve disease, but this study is believed to be the first to provide evidence that it may actually play a role in the disease.

The findings, published in the Feb. 7 issue of the New England Journal of Medicine, could help explain why aortic valve calcification runs in families. It might also lead to the development of new drugs to slow the progression of the disease.

"This is an important step forward in understanding the biology of the development of aortic stenosis and how this common genetic variant, which is found in 7 percent of the general population, contributes to that risk," study senior author Dr. Wendy Post, a cardiologist and associate professor of medicine and epidemiology at the Johns Hopkins University School of Medicine in Baltimore, said in a university news release.

Non-genetic risk factors for aortic valve calcification include older age, high blood pressure, obesity, high cholesterol levels and smoking. Men are more likely than women to develop aortic valve calcification.

More information

The U.S. National Heart, Lung, and Blood Institute has more about heart valve disease.

-- Robert Preidt

SOURCE: Johns Hopkins Medicine, news release, Feb. 6, 2013


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Electrical Brain Stimulation Plus Drug Fights Depression: Study
2. Mayo Clinic-led study identifies biomarkers for early risk assessment of acute kidney injury
3. Study to test whether hearing aids can help prevent falls
4. Study identifies skiers who can be successfully treated without surgery after an ACL tear
5. Study of brain cooling and clot-busting drug therapy for stroke receives FDA OK to expand
6. Shift to Hospice Care Often Comes Too Late, Study Finds
7. Steroid Shots for Tennis Elbow Miss the Mark: Study
8. Diabetes Drug May Offer Modest Weight Loss for Very Obese Teens: Study
9. Mammogram every 2 years has same benefit as yearly mammogram for older women, UCSF study finds
10. Sunshine Linked to Lower Rheumatoid Arthritis Risk: Study
11. Patient Involvement Lowers Health Costs, Study Says
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study Ties Gene to Dangerous Heart Valve Deposits
(Date:4/21/2017)... ... April 21, 2017 , ... Evoke Therapy ... adults, has kicked off its 4th annual Forum for Innovative Treatment Solutions (FITS), ... “Attachment Informed Therapy for Mental Health and Addiction.” , FITS’ 2017 keynote ...
(Date:4/21/2017)... (PRWEB) , ... April 21, 2017 , ... The adage ... Flex House, the next project in the company’s esteemed VISION House demonstration project series. ... use exactly the amount of resources they need to live affordably and abundantly without ...
(Date:4/21/2017)... Arvada, CO (PRWEB) , ... April 21, 2017 ... ... health and performance system, has partnered with O2X , an active lifestyle ... are focused on improving the health of firefighters, police offers, first responders, military ...
(Date:4/21/2017)... CA (PRWEB) , ... April 21, 2017 , ... ... Joseph Health held the much anticipated Regional Primary Care Spring Symposium on April ... in the local medical community, offering physicians and healthcare providers an opportunity to ...
(Date:4/21/2017)... City, UT (PRWEB) , ... April 21, 2017 , ... ... solutions, recently partnered with Advanced Patient Care of Utah (APCUT) and has appointed Rex ... for the next chapter of growth for our agency and our ability to provide ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)...  Sorrento Therapeutics, Inc. (NASDAQ: SRNE ... new treatments for cancer and other unmet medical ... announced underwritten public offering of 23,625,084 shares of ... of $2.00 per share, before deducting underwriting discounts ... Sorrento.  The net proceeds to Sorrento from this ...
(Date:4/18/2017)... Ohio , April 18, 2017  Cardinal Health ... Non-GAAP 1 fiscal 2017 earnings per share (EPS) ... and 2019.  This is in conjunction with this morning,s ... Deep Vein Thrombosis and Nutritional Insufficiency businesses. ... from continuing operations will be at the bottom of ...
(Date:4/18/2017)... BLOOMINGTON, Minn. , April 18, 2017 ... ) ("Imprimis"), an ophthalmology-focused pharmaceutical company, and Cameron ... announced the signing of a three-year exclusive sales ... deploy a dedicated sales team to introduce Imprimis, ... primarily focused in 13 states in the U.S. ...
Breaking Medicine Technology: