Navigation Links
Study Supports Wider Use of Statins
Date:7/1/2009

Data shows reduction in heart attacks, strokes among those without established heart disease

TUESDAY, June 30 (HealthDay News) -- An analysis of studies supports a growing belief that guidelines for prescribing cholesterol-lowering statin drugs should be expanded to include healthy people without established heart disease, cardiologists say.

The meta-analysis of 10 trials involving more than 70,000 participants found that statin therapy reduced overall mortality by 12 percent, major coronary events by 30 percent and strokes by 19 percent.

It supports the findings of the JUPITER trial, reported last year, which noted 54 percent fewer heart attacks and 48 percent fewer strokes among people taking a statin who had normal cholesterol levels but high levels of C-reactive protein, a marker of inflammation, said Dr. Antonio M. Gotto, Jr., dean of Weill Cornell Medical College, a member of the international team reporting on the meta-analysis in the BMJ online.

The analysis shows that "the more risk factors you have, the more aggressive you should be, and the lower the cholesterol level you should consider using statins for," Gotto said.

Primarily as a result of the JUPITER trial, the U.S. National Institutes of Health has announced that it will review the guidelines for prescribing statins, Gotto said. Those guidelines now focus on reducing elevated levels of LDL cholesterol, the "bad" kind that clogs arteries.

The increased benefit of statins is believed to be due to their anti-inflammatory activity, Gotto said.

The meta-analysis was undertaken before the JUPITER results were reported, Gotto said, because "there was a push against statin use in primary prevention in women and the elderly." Primary prevention is aimed at people who have cardiovascular risk factors, such as high blood pressure and diabetes, but have not been diagnosed with heart disease.

"We thought it was an important health problem that was not being addressed," Gotto said.

Previous trials were too small to provide definitive evidence that statin therapy would help women and older people who had risk factors for heart disease, he said. In the studies that were amassed for the meta-analysis, 34 percent of participants were women and 23 percent had diabetes.

Age should be a major consideration when considering statin therapy, but gender should also be taken into account, said Dr. Jacob W. Deckers of the department of cardiology at Erasmus Medical Center in the Netherlands, a member of the international team. The study indicates that statin therapy should be started 10 years earlier in men than in women with the same risk factors, he said.

"Statins should be prescribed in older men with a single risk factor and in older women with several risk factors," he said.

Only minimal side effects of statin therapy were found in the meta-analysis, Deckers said. No increased risk of cancer was seen, and the incidence of myalgia, the muscle pain that can accompany statin use, was one case in 10,000 persons, he said.

Many people who now take aspirin to reduce cardiovascular risk would be better off with statin therapy, Deckers said. Aspirin's anti-clotting effects reduce the risk of artery blockage but increase the risk of excess bleeding, he noted.

"It would be better to switch to a statin because of a better benefit-risk ratio," Deckers added. "With aspirin, the benefit is relatively low and the risk is relatively high."

More Information

Learn more about statins from the U.S. National Library of Medicine.



SOURCES: Antonio M. Gotto, Jr., M.D., dean, Weill Cornell Medical College, New York City; Jacob W. Deckers, M.D., department of cardiology, Erasmus Medical Center, Rotterdam, Netherlands; July 1, 2009 BMJ


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Penn study finds pro-death proteins required to regulate healthy immune function
2. New study shows promise in reducing surgical risks associated with surgical bleeding
3. Study, meta-analysis examine factors associated with death from heatstroke
4. Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinsons symptoms
5. Study says COPD testing is not measuring up
6. Preclinical study suggests organ-transplant drug may aid in lupus fight
7. Ability to cope with stress can increase good cholesterol in older white men, study finds
8. High alcohol consumption increases stroke risk, Tulane study says
9. Mailman School of Public Health study examines link between racial discrimination and substance use
10. Pitt study finds inequality in tobacco advertising
11. Stanford study highlights cost-effective method of lowering heart disease risks
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study Supports Wider Use of Statins
(Date:1/19/2017)... ... 19, 2017 , ... Sales Focus Inc. (SFI), a Maryland-based sales outsourcing company, ... Over the past 20 years SFI has been recognized as the world’s leader in ... clients into the US market. The new clients include: Panacea Pro, Campseekers, Contentmart, ...
(Date:1/19/2017)... ... 2017 , ... Each year, the Southeastern Society of Plastic ... of surgeons from over fifteen different countries come together to share and learn ... to breast reconstruction for breast cancer patients, teaching these surgical techniques which ...
(Date:1/18/2017)... ... January 18, 2017 , ... A recent video posting ... global discussion about the benefits of fidgeting to relieve stress and anxiety. No ... Their Think Ink Pen had just completed a successful Kickstarter campaign raising $67,000 ...
(Date:1/18/2017)... , ... January 18, 2017 , ... ... it from the number one doctor-recommended OTC antiperspirant, Certain Dri. , Excessive sweating ... untreated. , Certain Dri created this infographic to explain the seven types of ...
(Date:1/18/2017)... ... January 18, 2017 , ... ... industry’s leading journal and most-read publication among specialty pharmacists and pharmacy professionals, ... through its Strategic Alliance Partnership (SAP) program, announced Brian Haug, president of ...
Breaking Medicine News(10 mins):
(Date:1/18/2017)... and PUNE, India , January 18, ... Allied Market Research, titled, "Breast Imaging Technologies Market by Type: ... global breast imaging technologies market size was valued at $2,544 ... by 2022, growing at a CAGR of 8.4% from 2016 ... Europe together accounted for over three-fourths market ...
(Date:1/18/2017)... 2017   Regenicin, Inc. (OTC Bulletin Board: ... the development and commercialization of regenerative cell therapies to ... reported the Company,s operating results for 2016 and an ... the Company described in its recent 10-K filing with ... accomplishments. The Company,s contract laboratory completed its evaluation of ...
(Date:1/18/2017)... DAVOS , Suiza, 18 de enero de 2017 ... biofarmacéuticas líderes lanzaron Access Accelerated, una iniciativa global para ... comunicables (NCD) y atención en países de renta baja ... NCD han alcanzado un punto de crisis, particularmente en ... casi el 80 por ciento de las muertes relacionadas ...
Breaking Medicine Technology: