Navigation Links
Study Suggests Vaccine May Help Kids With Brain Cancer

TUESDAY, April 3 (HealthDay News) -- A vaccination may help boost the immune system of children with brain tumors, a small new study reports.

The prognosis for many children with brain tumors, known as gliomas, is grim. Radiation is the only effective treatment, although there has been hope that a vaccine could boost the immune system's response.

The results of the new study, which included 27 children and was funded by the U.S. National Institutes of Health, were released Monday at the annual meeting of the American Association for Cancer Research (AACR) in Chicago.

"We've found that the vaccine is tolerated well with limited systemic toxicity, but we've also observed that there are some patients who have immunological responses to the vaccine target in the brain that can cause swelling and transient worsening, and subsequently, some of those children can have very favorable responses," study lead author Dr. Ian Pollack said in an AACR news release.

"We've also demonstrated immunological responses in the majority of the kids," added Pollack, who is vice chairman for academic affairs in the department of neurological surgery at the University of Pittsburgh School of Medicine.

The study patients included 16 children with newly diagnosed brain stem gliomas, five with newly diagnosed cerebral high-grade gliomas and six with recurrent gliomas.

"These kids, who, for the most part, have intact and very robust immune systems, seem to mount an immune response against the vaccine very effectively at rates that may be even higher than have been noted in studies in adults," Pollack said in the news release.

"This was the first study of its type that examined peptide vaccine therapy for children with brain tumors like this," added Pollack, who is also the chief of pediatric neurosurgery at Children's Hospital of Pittsburgh and co-director of the University of Pittsburgh Cancer Institute Brain Tumor Program.

Some of the children experienced what is called "pseudoprogression" after receiving the vaccine, which means that the tumor temporarily grew and the disease symptoms worsened, but the tumor later got smaller and the disease stabilized, the study authors explained in the news release.

"The fact that we've seen tumor shrinkage in children with very high-risk tumors has been extremely encouraging and somewhat surprising," Pollack noted.

Commenting on the study findings, Dr. John Yu, director of surgical neuro-oncology and vice chair of the department of neurosurgery at the Cedars-Sinai Medical Center in Los Angeles, said that the impact on the immune systems of the patients is impressive.

"The safe and potentially effective nature of this vaccine would give thousands of patients new hope," Yu said. "Although one cannot glean whether this will improve their overall survival while maintaining a good quality of life, it provides some hope that harnessing the power of the immune system to fight off the brainstem glioma may kill tumor cells and provide a novel means of fighting off their disease."

Because this study was presented at a medical meeting, the data and conclusions should be viewed as preliminary until published in a peer-reviewed journal.

More information

For more about pediatric brain cancer, visit the U.S. National Library of Medicine.

-- Randy Dotinga

SOURCES: John S. Yu, M.D., director of surgical neuro-oncology and vice chair, department of neurosurgery, Cedars-Sinai Medical Center, Los Angeles; April 2, 2012, presentation, American Association for Cancer Research annual meeting, Chicago

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Despite Treatment, Employees with Depression Generate Higher Absentee Costs, According to Thomson Reuters Study
2. American Council on Exercise (ACE) Study Reveals Kettlebells Provide Powerful Workout in Short Amount of Time
3. TV drama can be more persuasive than news program, study finds
4. Study carried out into biological risks of eating reptiles
5. Neuroimaging study may pave way for effective Alzheimers treatments
6. Study finds racial gaps continue in heart disease awareness
7. Luth Researchs IndicatorEDG(TM) Study Finds Americans Hopes of Achieving Their Dreams Are Fading
8. First blinded study of venous insufficiency prevalence in MS shows promising results
9. Soothing infants with food focus of childhood obesity study
10. People with anxiety disorder less able to regulate response to negative emotions, study shows
11. American Heart Association Rapid Access Journal Report: Study Finds Racial Gaps Continue in Heart Disease Awareness, Low Knowledge of Heart Attack Warning Signs Among Women
Post Your Comments:
Related Image:
Study Suggests Vaccine May Help Kids With Brain Cancer
(Date:11/30/2015)... MN (PRWEB) , ... November 30, 2015 , ... ... at . The directory is specialized and only includes chiropractic clinics ... to find a competent and trustworthy alternative health practitioner when back pain sets ...
(Date:11/30/2015)... ... November 30, 2015 , ... In an effort ... the Word of Life Christian Church of Flint, MI, hosted a family-oriented evening ... 1.25 ton pile of candy dubbed “Candy Mountain”. , A Forever Recovery, a ...
(Date:11/30/2015)... ... November 30, 2015 , ... During ... fundraising campaign to raise funds for its research, education, support, and advocacy efforts. ... organization’s annual funding. , The Mesothelioma Applied Research Foundation, which also goes by ...
(Date:11/30/2015)... Dallas, TX (PRWEB) , ... November 30, 2015 ... ... its primary Catalyst continuing education course in Dallas, TX, on January 29 and ... are looking to improve the functions of their practices, to learn how to ...
(Date:11/30/2015)... , ... November 30, 2015 , ... ... chart and ingredient list of its hemorrhoid ointment to its website. , “Our ... relief for people suffering from hemorrhoids. Adding the comparison chart and ingredient list ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... and ST. LOUIS , Nov. ... (NASDAQ: ESRX ) today announced an early renewal ... which began in 1999, will now extend through at ... --> After evaluating pharmacy benefit manager capabilities during ... Express Scripts continues to offer the best health plan ...
(Date:11/30/2015)... Nov. 30, 2015 iCAD, Inc. (Nasdaq: ... feature its latest solutions for advanced image analysis ... cancer at the Radiological Society of North American ... from November 29 to December 4, ... including iReveal®, an automated breast density assessment solution, ...
(Date:11/30/2015)... 30, 2015 NHS Supply Chain has ... machines from Varian Medical Systems (NYSE: VAR ... replace older machines and institute modern radiotherapy and ... hospitals. The order, placed in September, also includes ... Varian,s RapidArc® and Eclipse™ software systems.    ...
Breaking Medicine Technology: