Navigation Links
Study Suggests Treatment with Paliperidone ER Significantly Improves Symptoms of Schizoaffective Disorder
Date:4/1/2009

to 12mg/day up to day 15, after which no dose adjustments were allowed. In addition to study medication, subjects were permitted to receive concomitant treatment with an antidepressant and/or mood stabilizer, provided these medications had been given at a stable dose within 30 days of screening. Approximately half the subjects enrolled received ongoing treatment with an antidepressant and/or mood stabilizer during the study.

Based on the primary outcome parameter of change in PANSS total score from baseline to week 6 endpoint results showed that patients in the paliperidone ER group had significantly greater improvement as compared to patients on placebo (p=0.001). Changes were also noted in many secondary outcomes parameters measured in the trial. The paliperidone ER group exhibited a significant improvement in mean Clinical Global Impressions of Severity for Schizoaffective Disorder (CGI-S-SCA) scores when compared to patients taking placebo (p=0.002). Further, among patients with prominent manic symptoms as measured by the Young Mania Ratings Scale (YMRS score greater than or equal to 16) paliperidone ER exhibited significant improvement compared to placebo on the YMRS (p=0.001). Likewise, among patients with prominent depressive symptoms as measured by the Hamilton Rating Scale for Depression (HAM-D-21 score greater than or equal to 16), paliperidone ER exhibited significant improvements compared to placebo on the HAM-D-21 (p<0.001).

The most common adverse events occurring in this trial were: headache (32%), dizziness (18%), insomnia (14%), akathisia (13%) and dyspepsia (12%).

The study was sponsored by Ortho-McNeil Janssen Scientific Affairs, LLC.

Paliperidone ER, an atypical antipsychotic medication, was first approved in the U.S. in December 2006. Janssen, Division of Ortho-McNeil-Janssen Pharmaceuticals, Inc., markets paliperidone ER as INVEGA(R). It is approved for the acute
'/>"/>

SOURCE Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (J&JPRD)
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related medicine news :

1. Harvest Technologies Announces Interim Study Results From Critical Limb Ischemia Trial in Chennai India
2. Abbott Initiates U.S. Study of Absolute Pro(TM) Peripheral Stent System for Iliac Artery Disease
3. Study Links Reduced Use of Mental Health Facilities, Nursing Homes and Other Public Services to "Smart Investments" in Supportive Housing
4. Joplin Citizens and Health Organizations Call on Missouri Gov. Nixon for Study, Action on High Incidence of Birth Defects and Chronic Diseases in Community
5. $5.5 million from Gates Foundation funds major study of childhood malnutrition
6. Study Casts Doubt on Influential Hospital Safety Survey
7. New Study Shows That Despite Recession, Consumer Hold-Outs Struggle To Have It All
8. Stanford Study on CyberKnife Radiosurgery for Prostate Cancer Demonstrates 100 Percent PSA Response at 33 months
9. Study Links Pesticides to Birth Defects
10. Study Shows Patients & Nurses Benefit From Continuous Vigilance Monitoring
11. Pathwork Tissue of Origin Test Validation Study Published in Journal of Clinical Oncology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/12/2014)... United Arab Emirates (PRWEB) July 12, 2014 ... another Los Angeles basketball legend is heading to the ... scorer and six-time champion will be in the UAE ... & Fitness Weekend in support of diabetes awareness. The ... an award-winning entertainment marketing and event management company based ...
(Date:7/12/2014)... Amarillo, Texas (PRWEB) July 12, 2014 ... and Breastfeeding Made Simple as a valuable new resource ... that roughly two-thirds of American women work away from ... many sources touting the benefits of breastfeeding, but often ... continuing to nurse their babies. With its evidence-based insights, ...
(Date:7/12/2014)... Restore My Vision Today is a new ... couple boasting very impressive credentials on the field of ... as a way to help consumers do without the ... respective patients’ treatments . , In particular, ... of pertinent information relevant to eye care like:, ...
(Date:7/12/2014)... 2014 Maxim Peptide, a website that ... used solely in scientific experiments, is currently celebrating its ... business, Maxim Peptide, which was created by the founders ... and updated website that now features a special deals ... updated with fascinating articles about peptide research, including a ...
(Date:7/12/2014)... 12, 2014 Ladies, it doesn't matter what ... Those who are looking for an affordable gown can ... occasion dresses) to get their dream items. Recently, the company ... length gowns . Along with that, it is also providing ... the special offer; the deadline of this promotion is July ...
Breaking Medicine News(10 mins):Health News:Los Angeles Basketball Legend Headed to Dubai 2Health News:Los Angeles Basketball Legend Headed to Dubai 3Health News:Praeclarus Press Announces the Release of Working and Breastfeeding Made Simple by Nancy Mohrbacher, A Much Needed Resource For Today's Working Mothers 2Health News:Restore My Vision Today | Groundbreaking Book Reveals How To Restore Your Vision Without The Use of Glasses – Vinamy 2Health News:Restore My Vision Today | Groundbreaking Book Reveals How To Restore Your Vision Without The Use of Glasses – Vinamy 3Health News:Maxim Peptide Celebrates Second Anniversary Online with an Updated Website and Special Deals Section 2Health News:Worldwide Brides-to-be: It Is Time To Show Your Beauty By Wearing A Trendy Summer Short Wedding Dress From Discount-Dress.com 2
... of Northwestern University, is a super sleuth of potentially ... team of doctors called RADAR (Research on Adverse ... School of Medicine. They swoop in to investigate early ... Administration (FDA) takes notice. ,A new study ...
... Court on Friday announced that it has accepted a ... to review the constitutionality of a Mexico City law ... the first three months' gestation, the Los Angeles Times ... Democratic Revolution in March in the Mexico City Legislature ...
... such as Girls Aloud, Pussycat Dolls and the Sugababes have ... promoting an ideal for what a womans figure should look ... ,Researchers from the universities of Leeds and Sussex ... where all the band-members are skinny, found that watching such ...
... in Physiological and Biochemical Zoology, a fascinating new ... evolution and artificial selection, providing insight into ... fluctuations. ,Dr. James Hicks, Editor in ... collection of papers: "This exciting approach experimental ...
... good for the fairer sex, for a new study has found that ... as fast as if she has just had a grueling workout. ... a group of 35 women and found that trying on a pair ... beats per minute. ,And, this is not just a one ...
... up boozing from home. ,Based on this, ... away from their middle school children, the best place to ... by a team of researchers including principal investigator Kelli Komro ... Minnesota, Minneapolis. ,As part of the study, researchers ...
Cached Medicine News:Health News:Researchers Found Drug Effects of Deadly Prescription Well Before FDA 2Health News:Researchers Found Drug Effects of Deadly Prescription Well Before FDA 3Health News:Mexico Supreme Court Accepts Petition To Review Mexico City Law Legalizing Abortion During First Three Months' Gestation 2Health News:Research Throws Light on Adaptation of E.coli to Changing Conditions 2
(Date:7/11/2014)... July 11, 2014 Research and Markets ... and Chinese Medical X-ray Film Industry Report 2014" ... http://photos.prnewswire.com/prnh/20130307/600769 Global And Chinese Medical X-Ray ... study on the current state of the Global medical ... situation. The report provides a basic overview of ...
(Date:7/11/2014)... On Thursday, July 10, 2014, the NASDAQ ... Average finished the day 0.42% lower at 16,915.07, and the ... broad based as eight out of ten sectors ended the ... ended the day at 711.88, down 0.02%, while the index ... initiated coverage on the following equities: Covidien PLC (NYSE: ...
(Date:7/11/2014)... Neurelis, Inc. ("Neurelis") today announced an agreement ... held by Biotie to purchase Neurelis, clearing the way ... diazepam) for pediatric and adult epilepsy patients who experience ... Biotie has advanced the development program for NRL-1 and ... work required for NDA submission to the FDA.  Given ...
Breaking Medicine Technology:Global and Chinese Medical X-ray Film Industry Report 2014 2Health Care Equipment Equities Movers and Shakers -- Research on Covidien, Baxter, DexCom, and Boston Scientific 2Health Care Equipment Equities Movers and Shakers -- Research on Covidien, Baxter, DexCom, and Boston Scientific 3Health Care Equipment Equities Movers and Shakers -- Research on Covidien, Baxter, DexCom, and Boston Scientific 4Neurelis Regains Rights to Intranasal Diazepam Program 2Neurelis Regains Rights to Intranasal Diazepam Program 3
... includes three major components: Blood pump, Cannulae, ... Driver. This system provides partial or total ... conventional therapy, is unable to maintain adequate ... support, blood flows from the natural heart ...
Datascope presents a unique new product for post-hemostasis puncture site management. Safeguard is the first product ever to combine a built-in inflatable bulb and a sterile dressing- providing adjus...
... catheter is inserted into the subclavian or ... vena cava. The Cool Line incorporates ... temperature-controlled saline flowing within a closed-loop design, ... circulation. The Cool Line combines two ...
... The Fortius catheter provides maximum ... to target temperature. The Fortius catheter ... design to provide the ultimate solution ... catheter is inserted percutaneously into the ...
Medicine Products: