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Study Suggests Link Between Sleep Deprivation, Alzheimer's Risk
Date:9/28/2011

is may be that the brain's low activity during sleep allows the body to clear amyloid beta through the spinal fluid.

Levels of amyloid beta in older adults with Alzheimer's appear to be constant, suggesting a possible link between lack of sleep and people's odds for developing the disease, the team said.

In conducting the study, the researchers divided study participants into three groups:

  • People aged 60 and older who tested positive for the presence of amyloid beta plaques in the brain.
  • People aged 60 and older who did not have amyloid beta plaques.
  • Healthy people ranging in age from 18 to 60 years.

Using a spinal tap, researchers monitored amyloid beta levels in the participants' spinal fluid every hour for up to 36 hours. During this time, they also videotaped the patients' activities and monitored their brain activity.

In the group with brain plaques, amyloid beta levels remained virtually constant. In the other two groups, however, the levels regularly rose and fell in snake-like waves. The highs and lows of this pattern were much more obvious in younger participants, and flatter in older people.

Although the participants' activities did not have an impact on changes in amyloid beta levels, peaks in their sleep and wakefulness consistently occurred before peaks and drops in amyloid beta levels.

The study authors said that more research is needed to explore how disrupted sleep in young people disrupts the normal ebb and flow of spinal amyloid beta, and how sleep aids may help maintain this wave-like pattern.

"It's still speculation, but there are tantalizing hints that better sleep may be helpful in reducing Alzheimer's disease risk," concluded Duntley. "We know from a number of studies that exercise enhances sleep, and research also has shown that exercise is associated with decreased risk of Alzheimer's. Sleep might be one link through which that effect occurs."

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