Navigation Links
Study Suggests Link Between Hormone Melatonin and Type 2 Diabetes
Date:4/2/2013

By Serena Gordon
HealthDay Reporter

TUESDAY, April 2 (HealthDay News) -- Decreased levels of the hormone melatonin may be linked to the development of type 2 diabetes, according to new research.

A study of U.S. women found that those with the lowest levels of melatonin had more than twice the risk of type 2 diabetes compared to women with the highest levels of the hormone. This association held true even after the researchers controlled for other risk factors for type 2 diabetes, such as body weight and dietary habits.

But whether too little melatonin actually causes type 2 diabetes isn't clear. "We found an association between melatonin and type 2 diabetes; what we haven't got from this study is causality," said study lead author Dr. Ciaran McMullan, a research fellow at Brigham and Women's Hospital in Boston. "That's the next step of research."

The findings shouldn't change clinical management. "There's no evidence that taking melatonin will improve someone's chances of avoiding diabetes," McMullan said.

Results of the study, which was funded by the National Institutes of Health, appear in the April 3 issue of the Journal of the American Medical Association.

Melatonin is a hormone most commonly linked to sleep and the body's biological clock. The production of melatonin peaks about three to five hours after you fall asleep in the dark, and almost no melatonin is produced during the day, according to background information in the study. Sleep disruptions can affect melatonin production, as can exposure to more or less daylight, McMullan said.

People with type 2 diabetes, by far the more common form of diabetes, don't make enough insulin or use it properly. Insulin is a hormone needed to convert sugar (glucose) from foods into energy.

Melatonin receptors are found throughout the body, including in the islet cells of the pancreas, which produce insulin. This connection suggests melatonin may also play a role in glucose metabolism, according to the study.

McMullan and his colleagues reviewed data from the U.S. Nurses' Health Study. The researchers found 370 women who developed type 2 diabetes during the study period, from 2000 to 2012. They also selected 370 women without diabetes for comparison. Melatonin levels were obtained through urine samples.

When researchers compared women with the lowest levels of melatonin to those with the highest, they found that low levels increased the risk of developing type 2 diabetes by 2.17 times.

McMullan said it's not yet clear how melatonin might affect the risk of type 2 diabetes. "The next step is to look at whether we can adjust melatonin secretion in people, and to confirm whether or not melatonin is a modifiable risk factor for type 2 diabetes," he said.

Dr. Joel Zonszein, director of the clinical diabetes center at Montefiore Medical Center in New York City, said the study illustrates the complexity of type 2 diabetes. "But it doesn't prove that taking melatonin would cause a person to be more insulin sensitive," he said.

"While there is a correlation between melatonin and insulin resistance, we cannot tell from this study if low melatonin is the cause," Zonszein said. "We are far away from melatonin as a treatment."

In the United States, about 8 percent of residents have diabetes, but many don't know it. The disease, a leading cause of heart disease and stroke, is typically associated with obesity, sedentary lifestyle and older age.

More information

Learn more about preventing type 2 diabetes from the American Diabetes Association.

SOURCES: Ciaran McMullan, M.D., research fellow, Brigham and Women's Hospital, Boston; Joel Zonszein, M.D., director, clinical diabetes center, Montefiore Medical Center, New York City; April 3, 2013, Journal of the American Medical Association


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Study Suggests Vaccine May Help Kids With Brain Cancer
2. Study reveals how cancer drug causes diabetic-like state
3. Coffee Drinking in Pregnancy Wont Lead to Sleepless Baby: Study
4. Lower GI problems plague many with rheumatoid arthritis, Mayo Clinic study finds
5. Veggies Like Broccoli, Cabbage May Help Fight Breast Cancer: Study
6. No Added Cancer Risk From Hip Replacement Materials: Study
7. Reported Decline in U.S. Pneumonia Deaths May Be False: Study
8. Early Study Finds Some Promise for Lung Cancer Vaccine
9. Narcissists Often Ace Job Interviews, Study Finds
10. Sexual objectification of female artists in music videos exists regardless of race, MU study finds
11. Soy may alleviate hot flashes in menopause, large-scale study finds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study Suggests Link Between Hormone Melatonin and Type 2 Diabetes
(Date:3/27/2017)... ... March 27, 2017 , ... ... enables researchers to pursue the recent RNA methylation “gold rush” with their established ... of the newfound characteristics of N6-methyladenosine, or m6A , RNA methylation has ...
(Date:3/27/2017)... ... March 27, 2017 , ... The Association of Healthcare ... will hold their first Northeast Regional AHVAP Meeting. For 2017, Dr. Hayes will ... chain and value analysis professionals have a ‘seat at the table’ with clinical ...
(Date:3/27/2017)... ... ... According to the American Cancer Society , the average 15-year survival ... the cancer spreads to other organs, bones, or lymph nodes, however, the 5-year survival ... latter group, tune in to Lifestyle Magazine on April 9, 2017, to ...
(Date:3/27/2017)... ... March 27, 2017 , ... ... sodium testing methods are complicated and require expert user knowledge. In a live ... method dedicated to the simplified, yet highly accurate, determination of sodium. , It ...
(Date:3/27/2017)... ... 27, 2017 , ... ?Grow Healthy Vending LLC announced today ... between itself and 1800 Vending DBA Healthy You Vending. (Civil No. 1:14-CV-00121-CW/ United ... announce that we have now reached a settlement agreement regarding the ongoing lawsuits ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... India , March 24, 2017 Abdominal Aortic Aneurysm Repair ... million by 2022, Globally, registering a CAGR of 5.1% from 2016 to 2022. The ... projected to dominate the market during the study period. ... ... ...
(Date:3/24/2017)... -- Research and Markets has announced the addition ... report to their offering. ... Pain Management in the U.S.: ... physical pain, emphasizing consumer survey analysis, including trends over time. ... who have selected illnesses/conditions strongly associated with physical pain and ...
(Date:3/24/2017)... FinancialBuzz.com News Commentary   ... Medical cannabis products around the world are projected to gain popularity. ... cannabis market will reach a value of USD 55.8 billion by 2025. ... new growing industry. By the end of 2016, 28 states have now ... More conservative states like Arkansas and ...
Breaking Medicine Technology: