Navigation Links
Study Suggests How Some Cancers Resist Treatment
Date:4/1/2010

Finding shows drug resistance can be lost, treatment can work again

THURSDAY, April 1 (HealthDay News) -- Scientists have identified a mechanism by which certain tumor cells that become resistant to cancer drugs can later lose that resistance.

The discovery may lead to new ways to combat drug resistance in cancer patients, said the authors of the new study, published online April 1 in the journal Cell.

Although the existence of these drug-resistant cells has been common knowledge, scientists "now understand a little bit better how those cells work so they can attack them," said Robert Clarke, a professor of oncology and physiology and biophysics at the Georgetown Lombardi Comprehensive Cancer Center in Washington, D.C.

Study senior author Jeffrey Settleman, scientific director of the Massachusetts General Hospital Cancer Center and professor of medicine at Harvard Medical School, said: "One of the big problems with cancer drug therapy is acquired drug resistance. Most treatments, even ones that work, fail over time because tumors become drug-resistant. It's been largely assumed, and in some cases even demonstrated, that random gene changes confer a lot of that resistance."

But some tumors become susceptible to the cancer drugs after a "drug holiday," indicating that other mechanisms are at play.

"There's a population of cells that's resistant but the resistance is not necessarily maintained forever," Clarke noted.

"This suggests that the resistance is not genetic but could be reversible," added Settleman.

Using models of drug-resistant cells, the study authors found a subpopulation of tumor cells that managed to escape the effects of cancer drugs even when given at levels 100 times greater than those that would kill most cells.

The authors tested a number of different drugs, including gefitinib (Iressa), which is used to treat lung cancer, and lapatinib {T
'/>"/>

Copyright©2010 ScoutNews,LLC.
All rights reserved

Page: 1 2 3

Related medicine news :

1. Study shows partial lung removal favorable over full removal as treatment for lung cancer
2. New mums beat the blues and increase wellbeing with physio exercise, study reveals
3. Small soda taxes insufficient to curb consumption among children, study finds
4. Study Revives Debate on Prostate Drug
5. Misinformation about antibiotics can travel to large audience via Twitter: study
6. Minority women least likely to gain access to a doctor, study says
7. New national study examines weight training-related injuries
8. Misinformation About Antibiotics Can Travel to Large Audience Via Twitter: Study
9. Radiation after mastectomy underused, U-M study finds
10. Study shows that mutations in 1 gene cause many cancers
11. Age Management Leader Goes Beyond 2010 NANES Study Reqs, Targeting Heightened Obesity Group, Adult 40+
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2014)... Fitness is something most people can add ... around the block to biking ten or more miles, adding ... maintain throughout the year. The Forbes Living talk show ... will feature special guests, tips to get started and cool ... series will air on most popular cable television networks. ...
(Date:8/1/2014)... Online retailer Disposable Medical Express has ... guarantee on their inventory of Tranquility incontinence care products. ... pads along with other personal care products. , ... a line of incontinence products that you love,” a ... works for you, you shouldn't have to compromise because ...
(Date:8/1/2014)... 01, 2014 We are very ... on AWS Marketplace. EspressReport ES-AMI delivers enterprise grade ... $0.50 per hour (AWS infrastructure charges apply). , ... enterprise BI and operational reporting system with strong ... ad hoc reporting. It allows users to easily ...
(Date:8/1/2014)... Stress management can be difficult in this day and ... diminish rest and leisure time, stress can mount up and ... a way to manage stress in order to be healthy ... good sense of work-life balance is the key to managing ... of SF Custom Chiropractic. “Stress, left unchecked, can not only ...
(Date:8/1/2014)... US (PRWEB) August 01, 2014 Register to ... one of the most active years on record for life ... in life sciences represented 22 percent of all venture dollars ... exits and achieved high valuations. , However, 2014 is ... a recent report by Silicon Valley Bank, while life sciences ...
Breaking Medicine News(10 mins):Health News:Forbes Living to Air Fitness Forward Series 2Health News:Disposable Medical Express Offering Low Price Guarantee On Tranquility Products 2Health News:Quadbase Systems Inc. Announces The Availability Of It’s Flagship Enterprise Reporting, Dashboard and BI Analytics Tool on Amazon’s AWS Marketplace 2Health News:SF Custom Chiropractic Celebrates National Relaxation Day and the Benefits of Massage Therapy for the Month of August 2Health News:Register to Join the Merrill DataSite's Webinar - Built to Sell: The Life Sciences Deal Climate 2Health News:Register to Join the Merrill DataSite's Webinar - Built to Sell: The Life Sciences Deal Climate 3
... the Prime Minister, Premiers and Chief Ministers urging the ... and childcare workers are trained in recognizing and handling ... COAG also should ensure the provision of legal immunity ... severe allergic reactions. ,'Greater awareness and ...
... says that Tai Chi, may be helpful in preventing ... been found not only to increase// the immunity to ... to varicella vaccine as well. ,This National ... clinical trial to suggest that a behavioral intervention, alone ...
... in Mumbai will soon start an integrated trauma care facility ... to patients on way to a hospital from an accident ... Physicians of Indian Origin (AAPI), the emergency medical service and ... within minutes of an accident. ,"The ambulance would ...
... Radiologists using computer-aided detection software for mammograms are more ... than "human reviewers using// their eyes and experience," and ... to a study. ,CAD systems use complex ... a radiologist to review. The systems, which cost $50,000 ...
... - supporting research and providing education, advocacy and ... - today said physicians should consider lowering the ... with multiple myeloma. ,High dose dexamethasone ... treatment of myeloma alone and in combination with ...
... McGill University in Montreal in Canada have found that by ... alter the speed with which the mice// learned to perform ... develop drugs to improve memory. ,The finding paves ... loss and dementia, but similar drugs might also improve the ...
Cached Medicine News:Health News:COAG Must Make Combating Severe Allergies A National Priority 2Health News:Tai Chi may Be Useful to Prevent Shingles in Older Adults 2Health News:Mumbai to Have Integrated Trauma Care Facility 2Health News:Mumbai to Have Integrated Trauma Care Facility 3Health News:New Clinical Trial Results Could Improve Survival for Myeloma Patients 2Health News:New Clinical Trial Results Could Improve Survival for Myeloma Patients 3Health News:Canadian Researchers Raise Hopes of Treatment for Memory Loss 2
(Date:7/31/2014)... July 31, 2014  Decision Resources Group,s ... about by the Affordable Care Act (ACA), ... of pharmaceutical therapies. The ACA altered how ... new regulations and expanded access via government-supported ... health exchanges—state-based marketplaces set up by states ...
(Date:7/31/2014)... Hovione today announced that its API ... passed a pre-approval inspection by the US Food and Drug ... FDA Consumer Safety Officer, Ms. Britanny Terhar , lasted ... July and concluded on the 25 th . The inspection ... guidelines of Good Manufacturing Practices (GMP) and no Form 483 ...
(Date:7/31/2014)... announces the list of stocks featured in the Analyst Blog. ... news and events impacting stocks and the financial markets. Stocks ... - Free Report ), Gilead (Nasdaq: GILD - Free ... ), AbbVie (NYSE: ABBV - Free Report ) and ... Today, Zacks is promoting its ,Buy, stock recommendations. Get ...
Breaking Medicine Technology:Health Exchanges Drive Change In MCO Strategies And Physician Prescribing Decisions; Impact On Pharma Mixed 2Health Exchanges Drive Change In MCO Strategies And Physician Prescribing Decisions; Impact On Pharma Mixed 3Health Exchanges Drive Change In MCO Strategies And Physician Prescribing Decisions; Impact On Pharma Mixed 4Successful FDA Inspection at Hovione's API Manufacturing Plant in Cork, Ireland 2The Zacks Analyst Blog Highlights: Biogen, Gilead, Puma Biotechnology, AbbVie and Celgene 2The Zacks Analyst Blog Highlights: Biogen, Gilead, Puma Biotechnology, AbbVie and Celgene 3The Zacks Analyst Blog Highlights: Biogen, Gilead, Puma Biotechnology, AbbVie and Celgene 4The Zacks Analyst Blog Highlights: Biogen, Gilead, Puma Biotechnology, AbbVie and Celgene 5The Zacks Analyst Blog Highlights: Biogen, Gilead, Puma Biotechnology, AbbVie and Celgene 6
... MADISON, N.J. and AUSTIN, Texas, May 24, 2011 ... Obstetrics & Gynecology demonstrated that adding OVA1 to ... would identify more ovarian cancers than a physician,s preoperative ... this month in the journal, which is the official ...
... May 24, 2011 The Board of Directors of BD (Becton, ... quarterly dividend of 41 cents per common share, payable on June ... indicated annual dividend rate is $1.64 per share. ... leading global medical technology company that develops, manufactures and sells medical ...
Cached Medicine Technology:OVA1 Improves Ovarian Cancer Detection Over CA 125 Blood Test and Clinical Assessment 2OVA1 Improves Ovarian Cancer Detection Over CA 125 Blood Test and Clinical Assessment 3OVA1 Improves Ovarian Cancer Detection Over CA 125 Blood Test and Clinical Assessment 4
... Insulin-like growth factor binding protein-3 (IGFBP-3) is the ... postnatal serum, as a component of the ~150 ... a molecule of IGF-I or IGF-II and ALS, ... actions of the IGFs. The molar concentration of ...
... Growth hormone (GH) is a monomeric protein ... anterior pituitary gland. GH is released from ... pulsatile manner under the regulatory control of ... [1]. The timing and frequency of GH ...
... hormone (GH) is a monomeric protein produced ... pituitary gland. GH is released from the ... manner under the regulatory control of hypothalamic ... The timing and frequency of GH release ...
... (IGF-I or somatomedin C) is a 7.6 kDa ... as a potent mitogen of cellular proliferation, exerting ... In the circulation, IGF-I is bound to IGF-binding ... of IGF-I by modulating the interaction of IGF-I ...
Medicine Products: