Navigation Links
Study Suggests How Cancers Spread to Lungs
Date:9/29/2008

A complex signaling system paves the way for metastasis, researchers say

MONDAY, Sept. 29 (HealthDay News) -- Cancers typically spread -- or metastasize -- to specific, predictable locations. Now researchers have a deeper molecular understanding of why, at least for lung metastases in mice.

The finding might someday lead to drug therapies that curb lung cancer metastasis in humans, experts say.

Dr. Yoshiro Maru of the Tokyo Women's Medical University and colleagues report that primary tumors transmit a series of signals throughout the body to "prepare the soil" in the lungs to accept the "seed" of a metastatic cell from solid tumors located elsewhere.

The key players in this process are signaling proteins, which pass back and forth like text messages between the tumor and the premetastatic lung, and then from the premetastatic lung to the tumor and the bone marrow.

"I think the important part of the paper is that it's putting molecules on these pathways between different cells ... and between the primary tumor and the soil," said Mikala Egeblad, an assistant research anatomist at the University of California, San Francisco.

Just as important, the new study suggests that blocking these signaling interactions could inhibit the ability of tumors to metastasize to the lungs.

The findings were published online Sept. 28 in the journal Nature Cell Biology.

According to Dr. Len Lichtenfeld, deputy chief medical officer of the American Cancer Society, much has been learned about what differentiates a benign growth from a more aggressive cancer, as well as the characteristics of cells that break off from a primary tumor and make their way to distant sites within the body -- that is, to metastasize. This study, however, examines how a tumor is able to colonize a particular tissue -- in this case, the lungs.

"This research takes a look at what allows the cancer cells to set up a home in the lungs of the mice," Lichtenfeld said. "By understanding that mechanism, they potentially could incorporate that theory into the treatment of patients and perhaps, by understanding those mechanisms, you may be able to take advantage of that to prevent that [metastasis] from happening."

Studying lung metastases in mice, Maru and his team investigated the cellular signals that accompany tumor migration to the lung. What they discovered was a sort of signaling cascade -- a series of protein messages flashing back and forth throughout the body.

According to their theory: Suppose a tumor in the colon or breast is preparing to metastasize. Before it does so, it sends out specific proteins called growth factors throughout the body.

In cancer-free lungs, local cells respond by producing a second signal: a pair of molecules called S100A8 and S100A9. Nearby lung monocytes respond to these messages by producing the third and final message, called SAA3. This causes immune cells called macrophages to amplify the signal even further, driving both immune cells and tumor cells to migrate to the lungs.

Both of those cell types express the receptor for SAA3 -- a protein called TLR4. According to Maru, "that's a big problem," because TLR4, in a healthier context, induces immune cells to get on the move. But in this case deadly cancer cells get moving, too.

In this way, "the tumor prepares the soil, the pre-metastatic site, prior to its settlement," Maru said.

According to Egeblad, this study suggests "how the tumor is preparing organs, and particularly lungs, so that when the cancer cells arrive, they have an easier time staying and growing."

Added Lichtenfeld, "If they can interfere with that mechanism, they can prevent that [metastasis] from happening, and this could then become an important part of cancer treatment in the future."

More information

For more on lung cancer, visit the U.S. National Cancer Institute.



SOURCES: Yoshiro Maru, M.D., Ph.D., professor and chair, Department of Pharmacology, Tokyo Women's Medical University, Japan; Mikala Egeblad, Ph.D., assistant researcher, University of California, San Francisco; Len Lichtenfeld M.D., deputy chief medical officer, American Cancer Society, Atlanta; Sept. 28, 2008, Nature Cell Biology, online


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Access to Physicians Is Consumers Highest Priority When Choosing a Health Plan, According to New Study
2. Study Confirms Effectiveness of Magnetic Therapy in Pain Relief
3. 27 National Nursing Organizations Join Together to Commission a Study of the Impact of Advanced Practice Registered Nurses on Healthcare Quality, Safety, and Effectiveness
4. Potential treatment option for severe emphysema under study
5. OHSU Cancer Institute researchers study breathing during radiation
6. Geisinger study: Increasing health care value improves health care quality
7. New Study Confirms Link Between Pain Pumps and Cartilage Damage -- Searcy Denney Law Firm Investigates Claims
8. UNC study: Parenting can override effect of genes in how babies respond to stress
9. Results From IMPROVE Study Show Therapeutic Effect of New Formulation of Rebif(R) at 16 Weeks in Patients With Multiple Sclerosis
10. Estrogen flooding our rivers, Université de Montréal study
11. Study suggests why heart attack victims do better with social support
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/20/2017)... ... ... As a leading dental practice, Wall Centre Dental supports Stroke Awareness Month ... bleeding gums in Vancouver, BC, may be developing gingivitis, the first stage of ... and diabetes. Drs. Parviz Roshan, Siamak Tehrani and Milton Reskovich offer laser gum therapy ...
(Date:6/20/2017)... ... June 20, 2017 , ... This year, participants in the ... finding product improvements that could reduce the occurrence of unplanned extubations (UEs). ... breathing or to provide medication. Sometimes, patient movement can cause unplanned extubations which ...
(Date:6/20/2017)... ... June 20, 2017 , ... Uniform Advantage ... featuring seven new products designed to create tailored looks and athleisure-inspired outfits. UA Flex ... cotton easy care stretch twill. , With trendy looks hitting the medical community, UA ...
(Date:6/20/2017)... ... , ... John D'Eri, CEO of Rising Tide Car Wash , will ... during the Autism Society of America 's 49th annual conference to be held ... (DJFF) was founded in 2002 as the nation's first autism organization focused exclusively ...
(Date:6/20/2017)... ... June 20, 2017 , ... International water ... The Sharon Kleyne Hour Power of Water, Global Climate Change and Your Health ... world’s water crisis and how it affects the human eyes. , According ...
Breaking Medicine News(10 mins):
(Date:6/9/2017)... , June 9, 2017 AirXpanders, Inc. ... focused on the design, manufacture, sale and distribution of ... on the progress of its commercial roll-out in ... available in more than one hundred (100) medical institutions ... AeroForm offers a needle-free alternative for women who ...
(Date:6/7/2017)... -- Endo International plc (NASDAQ: ENDP ) ... Joseph R. Goodwin , U.S. District Court Judge for ... , entered a case management order in MDL 2325, ... Litigation (the "MDL") that includes a provision requiring plaintiffs ... on specific causation within one hundred twenty (120) days ...
(Date:6/3/2017)... June 3, 2017  Eli Lilly and Company ... results from the Phase 3 MONARCH 2 study ... 6 inhibitor, in combination with fulvestrant, significantly improved ... alone in women with hormone-receptor-positive (HR+), human epidermal ... who have relapsed or progressed after endocrine therapy ...
Breaking Medicine Technology: