Navigation Links
Study Spots Gene That Plays Role in Infertility
Date:1/31/2008

Deleting PTEN in mice led to premature ovarian failure, researchers report

THURSDAY, Jan. 31 (HealthDay News) -- Scientists think they have discovered a mechanism that prompts early menopause and might account for some infertility problems in women.

PTEN -- a gene that's known for suppressing tumor growth -- apparently also keeps immature eggs in the ovary from ripening too quickly. When researchers deleted the PTEN gene in mice, the rodents ran out of their entire supply of eggs while they were still in the mouse equivalent of early adulthood. If ultimately applicable in humans, the revelation could lead to better infertility treatments.

"This finding is believed to have broad physiological, clinical and practical significance," said senior study author Kui Liu, an assistant professor of medical biochemistry and biophysics at Umea University, in Sweden. The report is published in the Feb. 1 issue of Science.

A woman's ovaries are made up of follicles, each of which contains an oocyte (the germ cell which will eventually give rise to an egg).

Over time, the majority of follicles remain dormant, acting as holding pens for immature oocytes. Some of these dormant follicles, however, slowly move over to the growing active follicle pool, where they are available for immediate release and, perhaps, fertilization. Menopause occurs when there are no more follicles and, therefore, no more oocytes left.

The length of a woman's reproductive life is determined by the size of her follicle pool and the rate at which this pool is depleted.

Until now, scientists have not completely understood what mechanisms are involved in this process.

For this study, Liu and colleagues deleted the PTEN gene in mice and found that these mice produced, at the most, one normal-sized litter after which they could no longer give birth. They were still in early adulthood (12 to 13 weeks of age) when they
'/>"/>

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Page: 1 2

Related medicine news :

1. Penn study finds pro-death proteins required to regulate healthy immune function
2. New study shows promise in reducing surgical risks associated with surgical bleeding
3. Study, meta-analysis examine factors associated with death from heatstroke
4. Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinsons symptoms
5. Study says COPD testing is not measuring up
6. Preclinical study suggests organ-transplant drug may aid in lupus fight
7. Ability to cope with stress can increase good cholesterol in older white men, study finds
8. High alcohol consumption increases stroke risk, Tulane study says
9. Mailman School of Public Health study examines link between racial discrimination and substance use
10. Pitt study finds inequality in tobacco advertising
11. Stanford study highlights cost-effective method of lowering heart disease risks
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study Spots Gene That Plays Role in Infertility
(Date:12/17/2014)... -- Expectant parents should leave prenatal picture-taking to medical ... Use of ultrasound imaging and heartbeat monitors to get ... agency warns. "Although there is a lack ... and heartbeat monitors, prudent use of these devices by ... FDA biomedical engineer, said in an agency news release. ...
(Date:12/17/2014)... HealthDay Reporter , TUESDAY, Dec. 16, 2014 (HealthDay ... work commitment is a big reason why, new research suggests. ... Mathias Basner, an assistant professor of sleep and chronobiology in ... A time-use survey of nearly 125,000 Americans, ages 15 ... exchanged for sleep. Short sleepers -- those who slept six ...
(Date:12/15/2014)... December 15, 2014 South Florida’s leading urgent ... holidays can be a daze of hassle, hustle, and bustle ... while decking halls, to burns when making special meals and ... that can happen at any time. To prevent this season ... has made a list of helpful and healthful holiday tips ...
(Date:12/15/2014)... News) -- Expert pilots process visual information more efficiently ... better decisions during landings, a new study shows. ... pilots to master, and 36 percent of all airplane ... final approach and landing. Researchers monitored the brain ... pilots while they were at the controls of a ...
(Date:12/15/2014)... 15, 2014 At the leading, long-established ... AutismOne and Focus Autism will welcome ... research on the effects of toxins to children’s health, ... information. , Luminaries such as Dr. Lucija Tomljenovic ... with esteemed, credentialed colleagues of the United States to ...
Breaking Medicine News(10 mins):Health News:FDA Warns Against Fetal 'Keepsake' Videos 2Health News:Work Steals Valuable Sleep Time, Study Finds 2Health News:Work Steals Valuable Sleep Time, Study Finds 3Health News:MD Now Urgent Care Presents Healthy Holiday Tips 2Health News:MD Now Urgent Care Presents Healthy Holiday Tips 3Health News:Study Shows Why Expert Pilots Are Experts 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 3
... Fostering innovation to speed the improvement of health care ... researchers at Cincinnati Children,s Hospital Medical Center. "The ... broken," says Peter Margolis, MD, PhD, co-Principal Investigator of ... our previous successes, is to create a totally new ...
... , , , ... today that it has changed its corporate name to Ocular Therapeutix, ... more clearly articulates our mission in the ophthalmic marketplace as we ... and develop ocular drug delivery therapies." , , ...
... the psychological distress and burnout experienced by many physicians ... Center researchers report in today,s issue of the ... ). The training also can expand a physician,s ... according to the researchers, who were led by Michael ...
... , Former Vermont Governor to sign new book ... Sept. 23 -- Governor Howard Dean will be in Philadelphia, PA and ... and sign copies of his new book, Howard Dean,s Prescription for Real ... at the Philadelphia Free Library for a noon book signing and discussion. ...
... , , , , ... & Lione, one of the largest intellectual property law firms in the U.S., ... its long-time client Cook Incorporated in a patent infringement case brought by Edwards ... Appeals for the Federal Circuit affirmed the previous ruling of the U.S. District ...
... though, that biggest risk factor is the brain attack itself ... reduce the chances of developing dementia such as Alzheimer,s disease ... concentrating on all the known stroke risk factors, a new ... analysis of 30 previous studies that involved more than 7,500 ...
Cached Medicine News:Health News:Open innovation networks are one key to improved care 2Health News:Open innovation networks are one key to improved care 3Health News:Open innovation networks are one key to improved care 4Health News:Open innovation networks are one key to improved care 5Health News:Mindful meditation, shared dialogues reduce physician burnout 2Health News:Mindful meditation, shared dialogues reduce physician burnout 3Health News:Mindful meditation, shared dialogues reduce physician burnout 4Health News:Brinks Hofer Gilson & Lione Wins Patent Appeal for Cook Incorporated 2Health News:Brinks Hofer Gilson & Lione Wins Patent Appeal for Cook Incorporated 3Health News:Preventing Second Stroke May Stave Off Dementia 2Health News:Preventing Second Stroke May Stave Off Dementia 3
(Date:12/17/2014)... December 17, 2014 Revenue and earnings ... on research and development In the past 2013/14 ... by two percent to EUR 4.287 billion (last year: EUR ... 14 percent to EUR 360 million. "Overall, 2013/14 was a ... Michael Kaschke , President and CEO of Carl Zeiss AG. ...
(Date:12/17/2014)... 2014  Beamz Interactive, Inc. (OTCQB: BZIC), a ... announced that it has signed an agreement with ... of innovative prosthetic, orthotic and assistive technology products ... agreement, RSL Steeper will promote and supply the ... use within UK residential care facilities through its ...
(Date:12/17/2014)... , Dec. 17, 2014  RXi Pharmaceuticals Corporation ... focused on discovering, developing and commercializing innovative therapies ... today announced completion of enrollment in its first Phase ... 3-month observations confirmed the 1-month findings that were ... Logo - http://photos.prnewswire.com/prnh/20130917/NE80755LOGO , ...
Breaking Medicine Technology:ZEISS Asserts its Position in Difficult Environment 2Beamz Interactive, Inc. Signs UK Distribution Agreement with RSL Steeper Limited 2Beamz Interactive, Inc. Signs UK Distribution Agreement with RSL Steeper Limited 3RXi Pharmaceuticals Announces Sustained Effect of RXI-109 at Three Months Post Scar Revision Surgery and the Completion of Enrollment for its Phase 2a Trial RXI-109-1301 2RXi Pharmaceuticals Announces Sustained Effect of RXI-109 at Three Months Post Scar Revision Surgery and the Completion of Enrollment for its Phase 2a Trial RXI-109-1301 3RXi Pharmaceuticals Announces Sustained Effect of RXI-109 at Three Months Post Scar Revision Surgery and the Completion of Enrollment for its Phase 2a Trial RXI-109-1301 4RXi Pharmaceuticals Announces Sustained Effect of RXI-109 at Three Months Post Scar Revision Surgery and the Completion of Enrollment for its Phase 2a Trial RXI-109-1301 5
Straight chisel for scoring, cutting, scraping, cleaning and sculpting bone....
Custom-made chisels....
Lewin Bone Forceps, serrated and slightly curved. To hold, stabilize, rotate, reduce and,compress bone....
To elevate, dissect, scrape and apply traction to bone and soft tissue....
Medicine Products: