Navigation Links
Study Spots Gene That Plays Role in Infertility
Date:1/31/2008

Deleting PTEN in mice led to premature ovarian failure, researchers report

THURSDAY, Jan. 31 (HealthDay News) -- Scientists think they have discovered a mechanism that prompts early menopause and might account for some infertility problems in women.

PTEN -- a gene that's known for suppressing tumor growth -- apparently also keeps immature eggs in the ovary from ripening too quickly. When researchers deleted the PTEN gene in mice, the rodents ran out of their entire supply of eggs while they were still in the mouse equivalent of early adulthood. If ultimately applicable in humans, the revelation could lead to better infertility treatments.

"This finding is believed to have broad physiological, clinical and practical significance," said senior study author Kui Liu, an assistant professor of medical biochemistry and biophysics at Umea University, in Sweden. The report is published in the Feb. 1 issue of Science.

A woman's ovaries are made up of follicles, each of which contains an oocyte (the germ cell which will eventually give rise to an egg).

Over time, the majority of follicles remain dormant, acting as holding pens for immature oocytes. Some of these dormant follicles, however, slowly move over to the growing active follicle pool, where they are available for immediate release and, perhaps, fertilization. Menopause occurs when there are no more follicles and, therefore, no more oocytes left.

The length of a woman's reproductive life is determined by the size of her follicle pool and the rate at which this pool is depleted.

Until now, scientists have not completely understood what mechanisms are involved in this process.

For this study, Liu and colleagues deleted the PTEN gene in mice and found that these mice produced, at the most, one normal-sized litter after which they could no longer give birth. They were still in early adulthood (12 to 13 weeks of age) when they
'/>"/>

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Page: 1 2

Related medicine news :

1. Penn study finds pro-death proteins required to regulate healthy immune function
2. New study shows promise in reducing surgical risks associated with surgical bleeding
3. Study, meta-analysis examine factors associated with death from heatstroke
4. Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinsons symptoms
5. Study says COPD testing is not measuring up
6. Preclinical study suggests organ-transplant drug may aid in lupus fight
7. Ability to cope with stress can increase good cholesterol in older white men, study finds
8. High alcohol consumption increases stroke risk, Tulane study says
9. Mailman School of Public Health study examines link between racial discrimination and substance use
10. Pitt study finds inequality in tobacco advertising
11. Stanford study highlights cost-effective method of lowering heart disease risks
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study Spots Gene That Plays Role in Infertility
(Date:8/29/2014)... (PRWEB) August 29, 2014 As a ... City, Fla., understands that there’s a direct connection between ... knees, hips and back. "Since conventional shoe inserts and ... a solution of my own," he said. , Customizable ... provides better support for the foot in order to ...
(Date:8/29/2014)... 29, 2014 Glendale Botox experts ... on Botox throughout the month of September. This special offer ... two syringes of Juvederm. Patients can take advantage of this ... The Glendale Botox experts will work with patients to determine ... What is Botox? , Botox is a treatment ...
(Date:8/29/2014)... (HealthDay News) -- The main strain of a ... and North Africa originated in sub-Saharan Africa, a ... methicillin-resistant Staphylococcus aureus (CA-MRSA) infections, which ... been hospitalized. These infections typically affect the skin ... through touching contaminated objects such as clothing or ...
(Date:8/29/2014)... 2014 (HealthDay News) -- The way that parents respond ... development, a new study suggests. Over six months, ... infants during free play. The sessions were 30 minutes ... 8 months old at the start of the study. ... babbling, infants began to form complex sounds. The babies ...
(Date:8/29/2014)... August 29, 2014 For the fifth ... (Meso Foundation) will be observing September 26th as Mesothelioma ... Plaza, in New York. , Members of the ... RSVP . The Foundation will be providing t-shirts and ... years, mesothelioma community members have received attention from ...
Breaking Medicine News(10 mins):Health News:Glenoaks Laser Center is Now Offering a Special Promotion on Botox for the Month of September 2Health News: European MRSA Originated in Sub-Saharan Africa, Study Finds 2Health News:Encouraging Your Baby's Babbling May Speed Language Development 2Health News:Organization to Raise Awareness of Mesothelioma on the Today Show 2
... mental function, study says , , THURSDAY, June 12 ... to fight cancer may reduce disease activity and disability ... small trial suggest. , In relapsing-remitting MS, the ... of symptoms followed by stretches of symptom-free remission when ...
... 12 Cancer Clinics of Excellence (CCE), the,nation,s ... has announced its management slate and Board of ... CCE. Most,recently, he was the interim President of ... Group was named Chief Medical,Officer. Dr. Bosserman had ...
... 12 Do you know a,Champion?, The ... working to improve Oklahoma,s health. The 2008 Champions ... are making a,significant difference in the health of ... Friday, Aug. 1., Nominations can be submitted ...
... June 12 The Arizona Board of Regents,recently ... of Arizona,College of Medicine Program in Integrative Medicine ... medicine has had on health-care,system transformation., Now ... (AzCIM), the,program underwent an intensive evaluation process and ...
... performance and lifestyle brand is paired with LensCrafters, ... 500 North American stores, MASON, Ohio, June ... at more than 500 select LensCrafters locations, North ... customers the,combined benefits of Oakley,s popular and innovative ...
... to call, write letters to Schwarzenegger,expressing their outrage, ... of home healthcare workers will rally to protest ... service, wages and,benefits. These dramatic reductions would force ... they serve deeper into poverty. It also,will force ...
Cached Medicine News:Health News:Cancer Drug Appears to Help With Aggressive MS 2Health News:Cancer Clinics of Excellence (CCE) Announces Management and Board of Directors Slate at 1st Annual General Membership Meeting 2Health News:Nominations Accepted for 2008 'Champions of Health' Awards 2Health News:The University of Arizona Program in Integrative Medicine Earns 'Center of Excellence' Designation 2Health News:The University of Arizona Program in Integrative Medicine Earns 'Center of Excellence' Designation 3Health News:Oakley Prescription Eyewear Now at Lenscrafters 2Health News:Oakley Prescription Eyewear Now at Lenscrafters 3Health News:Oakley Prescription Eyewear Now at Lenscrafters 4
(Date:8/28/2014)... 2014 Reportlinker.com announces that a ... its catalogue: Needle-Free Delivery: Technology ... http://www.reportlinker.com/p02332847/Needle-Free-Delivery-Technology-and-Market-Forecast-2014-2024.html Report Details ... commercial prospects What does the future hold ... new report shows you the potential revenues ...
(Date:8/28/2014)... , Aug. 28, 2014  Decision Resources Group ... will grow strongly through 2022 at a compound ... will be largely supported by strong population growth ... demand for imaging procedures. The Indian government,s greater ... facilities to purchase or upgrade diagnostic imaging equipment. ...
(Date:8/28/2014)... , Aug. 28, 2014 /PRNewswire-iReach/ -- EDGE Orthopaedics, ... space, is excited to announce they have received ... Plating System and REDUCE Fracture Plating System. ... used to support multiple indications within the mid-foot. ... First Metatarsophalangeal (MTP), Calcaneal-Cuboid (CC), Talonavicular (TN) and ...
Breaking Medicine Technology:Needle-Free Delivery: Technology and Market Forecast 2014-2024 2Needle-Free Delivery: Technology and Market Forecast 2014-2024 3Needle-Free Delivery: Technology and Market Forecast 2014-2024 4Needle-Free Delivery: Technology and Market Forecast 2014-2024 5Needle-Free Delivery: Technology and Market Forecast 2014-2024 6Needle-Free Delivery: Technology and Market Forecast 2014-2024 7Needle-Free Delivery: Technology and Market Forecast 2014-2024 8Needle-Free Delivery: Technology and Market Forecast 2014-2024 9Needle-Free Delivery: Technology and Market Forecast 2014-2024 10Needle-Free Delivery: Technology and Market Forecast 2014-2024 11Needle-Free Delivery: Technology and Market Forecast 2014-2024 12Needle-Free Delivery: Technology and Market Forecast 2014-2024 13Needle-Free Delivery: Technology and Market Forecast 2014-2024 14Needle-Free Delivery: Technology and Market Forecast 2014-2024 15Needle-Free Delivery: Technology and Market Forecast 2014-2024 16Needle-Free Delivery: Technology and Market Forecast 2014-2024 17Needle-Free Delivery: Technology and Market Forecast 2014-2024 18Indian Diagnostic Imaging System Market Will Grow at 6 Percent Annually Through 2022 2Indian Diagnostic Imaging System Market Will Grow at 6 Percent Annually Through 2022 3EDGE Orthopaedics Receives Second FDA Clearance 2
... NEW YORK, Aug. 25 Reportlinker.com ... report is available in its catalogue: ... the Asia-Pacific Region – India and ... still dominates high value transactions ...
... (Nasdaq: BIOD ) today announced that it has ... 2,398,200 shares of its common stock and warrants to purchase ... warrants are being sold as units, with each unit consisting ... purchase one share of common stock.   The ...
Cached Medicine Technology:Reportlinker Adds Pharmaceutical M&A in the Asia-Pacific Region - India and China drive regional activity but Japan still dominates high value transactions 2Reportlinker Adds Pharmaceutical M&A in the Asia-Pacific Region - India and China drive regional activity but Japan still dominates high value transactions 3Reportlinker Adds Pharmaceutical M&A in the Asia-Pacific Region - India and China drive regional activity but Japan still dominates high value transactions 4Reportlinker Adds Pharmaceutical M&A in the Asia-Pacific Region - India and China drive regional activity but Japan still dominates high value transactions 5Reportlinker Adds Pharmaceutical M&A in the Asia-Pacific Region - India and China drive regional activity but Japan still dominates high value transactions 6Reportlinker Adds Pharmaceutical M&A in the Asia-Pacific Region - India and China drive regional activity but Japan still dominates high value transactions 7Reportlinker Adds Pharmaceutical M&A in the Asia-Pacific Region - India and China drive regional activity but Japan still dominates high value transactions 8Reportlinker Adds Pharmaceutical M&A in the Asia-Pacific Region - India and China drive regional activity but Japan still dominates high value transactions 9Biodel to Raise $9.4 Million Through Registered Direct Offering 2Biodel to Raise $9.4 Million Through Registered Direct Offering 3
... eye-nasal. High volume/low pressure cuff. X-ray ... surgical access. Designed to reduce kinking ... preformed curvature. Thin-walled, large volume low-pressure ... the anatomical situation at body temperature. ...
Ruschelit® PVC. Siliconized. Stainless steel spiral reinforced. High volume/low pressure cuff. Permanent connector. X-ray opaque. Single use. Sterile...
Tube for Right Bronchus - Ruschelit™ PVC. Color coded for easy identification of ports, balloons and 15mm connectors. High volume/low pressure cuffs. With Carina hook. X-ray opaque line. Gradua...
... For Laryngotracheal Instillation of Topical Anesthetic, ... populations, this cuffed tube incorporates an ... spray application of topical anesthetic above ... offers three endotracheal tubes designs which ...
Medicine Products: