Navigation Links
Study Spotlights a Natural Infection Fighter
Date:1/3/2008

The body produces its own hydrogen peroxide, but it must be kept in balance

THURSDAY, Jan. 3 (HealthDay News) -- The human body makes its own hydrogen peroxide --- the same disinfectant found in many first-aid kits and bathroom cabinets -- to help fight infections and keep cells healthy.

But when levels of hydrogen peroxide in the body get too high, this can endanger cell structures.

Now, researchers at Wake Forest University School of Medicine, in Winston-Salem, N.C., have released a detailed description of the way in which two proteins work together to keep hydrogen peroxide levels where they should be.

Writing in the Jan 3 issue of Nature, they describe the activity of a molecule called peroxiredoxin (Prx), which helps keep hydrogen peroxide levels below the amount that would cause damage to cellular structures. According to the researchers, Prx turns extra hydrogen peroxide into water, but when levels of the compound are very high, Prx starts calling on other proteins to help with the task.

"It basically acts as a sensor and warns the cell that levels are too high, and that the cell needs to respond," lead author Thomas J. Jonsson, a postdoctoral fellow at Wake Forest, said in a prepared statement. "Once that threat is gone, Prx needs to go back to its normal state."

The question the team wanted to answer was how Prx returned to its normal state. Previous research indicated that a protein called sulfiredoxin (Srx) participated in that process. The team used X-ray crystallography to understand how Srx worked with Prx. The technology allowed the team to capture the process in three dimensions.

What the research team found is a process they refer to as an "embrace": Prx unfolds, flips around and attaches itself to the back of Srx. That embrace creates a chemical reaction that repairs Prx.

According to the researchers, understanding the ways in which proteins work to keep cells healthy may give insight into the way in which damage occurs when the process does not work correctly.

More information

To learn more about cell structure visit the U.S. National Cancer Institute.



-- Madeline Vann



SOURCE: Wake Forest University Baptist Medical Center, news release, Jan. 2, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Carnegie Mellon study identifies where thoughts of familiar objects occur inside the human brain
2. American College of Physicians receives grant to study cost of patient-centered medical home
3. New study in the journal Sleep finds that catathrenia can be successfully treated with CPAP
4. Allergic reactions to gadolinium-based contrast agents are rare, study finds
5. LASIK works well, according to long-term study of highly myopic patients
6. Study Sheds Light on Origins of Sudden Cardiac Death
7. Study Spotlights Exercise-Friendly Day-Care Centers
8. Breast cancer gene mutation more common in Hispanic, young black women, Stanford/NCCC study finds
9. Study suggests some brain injuries reduce the likelihood of post-traumatic stress disorder
10. Kaiser Permanente -- Group Health study shows depression worsens HIV treatment
11. Most breast cancer surgeons dont talk to patients about reconstruction options, U-M study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... 13, 2017 , ... While it’s often important to take certain medications during ... Austin, Texas, has identified a solution. , She developed a prototype for MOTION LIGHT-UP ... such, it eliminates the need to turn on a light when taking medication during ...
(Date:10/13/2017)... ... October 13, 2017 , ... PurhealthRX , a ... utilizing Purzorb™ technology. Applying the Purzorb™process to full spectrum CBD oil will revolutionize the ... a CBD form that can be easily incorporated into liquid products, while reducing costs ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Apple Rehab ... services, staged a mock evacuation of the facility as part of a disaster drill ... Department, Echo Hose EMS and Shelton City Emergency Manager, as well as the ...
(Date:10/13/2017)... ... October 13, 2017 , ... Ellevate Network, the leading network ... advocate for action towards gender equality at their inaugural Summit in New York City ... and reached a social audience of over 3 million. To watch the Mobilize Women ...
(Date:10/13/2017)... ... October 13, 2017 , ... Talented host, actor ... on sciatica in a new episode of "Success Files," which is an award-winning ... innovation and investigates each subject in-depth with passion and integrity. , Sciatica occurs ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... Oct. 11, 2017  Hill-Rom Holdings, Inc. ("Hill-Rom") (NYSE: ... facility in Las Piedras, Puerto Rico ... blades. Following ... facility sustained minor structural damage, temporary loss of power ... have been completed, manufacturing operations have resumed, and the ...
(Date:10/4/2017)...  South Korean-based healthcare product Development Company I.M. Lab ... Kickstarter. The device will educate the user about ,proper, ... efficiency compared to the dated and pricey CPR training ... of the compression for a more informed CPR training. ... raise $5,000. cprCUBE ...
(Date:10/2/2017)...  AllianceRx Walgreens Prime, the combined central specialty pharmacy ... benefit manager Prime Therapeutics LLC (Prime), today officially began ... unveiling of new signage at its headquarters in ... a few other company-owned facilities across the country. This ... of whom will begin to see the AllianceRx Walgreens ...
Breaking Medicine Technology: