Navigation Links
Study Spotlights a Natural Infection Fighter

The body produces its own hydrogen peroxide, but it must be kept in balance

THURSDAY, Jan. 3 (HealthDay News) -- The human body makes its own hydrogen peroxide --- the same disinfectant found in many first-aid kits and bathroom cabinets -- to help fight infections and keep cells healthy.

But when levels of hydrogen peroxide in the body get too high, this can endanger cell structures.

Now, researchers at Wake Forest University School of Medicine, in Winston-Salem, N.C., have released a detailed description of the way in which two proteins work together to keep hydrogen peroxide levels where they should be.

Writing in the Jan 3 issue of Nature, they describe the activity of a molecule called peroxiredoxin (Prx), which helps keep hydrogen peroxide levels below the amount that would cause damage to cellular structures. According to the researchers, Prx turns extra hydrogen peroxide into water, but when levels of the compound are very high, Prx starts calling on other proteins to help with the task.

"It basically acts as a sensor and warns the cell that levels are too high, and that the cell needs to respond," lead author Thomas J. Jonsson, a postdoctoral fellow at Wake Forest, said in a prepared statement. "Once that threat is gone, Prx needs to go back to its normal state."

The question the team wanted to answer was how Prx returned to its normal state. Previous research indicated that a protein called sulfiredoxin (Srx) participated in that process. The team used X-ray crystallography to understand how Srx worked with Prx. The technology allowed the team to capture the process in three dimensions.

What the research team found is a process they refer to as an "embrace": Prx unfolds, flips around and attaches itself to the back of Srx. That embrace creates a chemical reaction that repairs Prx.

According to the researchers, understanding the ways in which proteins work to keep cells healthy may give insight into the way in which damage occurs when the process does not work correctly.

More information

To learn more about cell structure visit the U.S. National Cancer Institute.

-- Madeline Vann

SOURCE: Wake Forest University Baptist Medical Center, news release, Jan. 2, 2008

Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Carnegie Mellon study identifies where thoughts of familiar objects occur inside the human brain
2. American College of Physicians receives grant to study cost of patient-centered medical home
3. New study in the journal Sleep finds that catathrenia can be successfully treated with CPAP
4. Allergic reactions to gadolinium-based contrast agents are rare, study finds
5. LASIK works well, according to long-term study of highly myopic patients
6. Study Sheds Light on Origins of Sudden Cardiac Death
7. Study Spotlights Exercise-Friendly Day-Care Centers
8. Breast cancer gene mutation more common in Hispanic, young black women, Stanford/NCCC study finds
9. Study suggests some brain injuries reduce the likelihood of post-traumatic stress disorder
10. Kaiser Permanente -- Group Health study shows depression worsens HIV treatment
11. Most breast cancer surgeons dont talk to patients about reconstruction options, U-M study finds
Post Your Comments:
(Date:11/28/2015)... PITTSBURGH, PA (PRWEB) , ... November 28, 2015 , ... ... Manalapan, N.J., has created the COUCH BUDDY. "I conceived of this design due to ... more comfort for couch users. It promotes relaxation and convenience, as well as increases ...
(Date:11/27/2015)... Angeles, CA (PRWEB) , ... November 27, 2015 , ... ... conversation at the recent 2015 American Dental Association meeting in Washington D.C. revolved around ... help protect a patient’s overall health. The talk stressed the link between periodontal disease ...
(Date:11/27/2015)... Raleigh, NC (PRWEB) , ... November 27, 2015 , ... ... most effective ways to treat it. Surviving Mesothelioma has just posted the findings ... Researchers at University Hospital Zurich analyzed the cases of 136 mesothelioma patients who were ...
(Date:11/27/2015)... ... November 27, 2015 , ... The print component of ... in Atlanta, Dallas, New York, Minneapolis, South Florida, with a circulation of approximately ... nationally, through a vast social media strategy and across a network of top ...
(Date:11/27/2015)... ... November 27, 2015 , ... Intellitec ... Dynamics SL User Group (MSDSLUG). Recognized as Microsoft’s official group for end users ... Dynamics SL software users, partners, industry experts and representatives. Intellitec Solutions’ membership status ...
Breaking Medicine News(10 mins):
(Date:11/27/2015)... ) ... "2016 Global Tumor Marker Testing Market: Supplier ... Segment Forecasts, Innovative Technologies, Instrumentation Review, Competitive ... offering. --> ) has ... Global Tumor Marker Testing Market: Supplier Shares ...
(Date:11/26/2015)... --> --> ... immunotherapy with Bremachlorin-photodynamic therapy for advanced cancer.   ... with Bremachlorin-photodynamic therapy for advanced cancer.   ... with Bremachlorin-photodynamic therapy for advanced cancer.   ... immunotherapy can be efficiently combined with photodynamic therapy (PDT) ...
(Date:11/26/2015)... , November 26, 2015 3D ... by 2022, according to a new report by Grand View ... Kidney Disease (CKD) which demands kidney transplantation is expected to ... cost effective substitute for organ transplantation. --> 3D ... by 2022, according to a new report by Grand View ...
Breaking Medicine Technology: