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Study Shows a Link Between Schizophrenia & Genetic Mutations
Date:7/20/2009

ge, it is actually a very substantial and significant finding since schizophrenia is believed to be associated with a variety of causes and a particular cause that may be responsible for 4% of the disease would be quite significant. Biochemical tests of the ultra-rare variants demonstrated alterations in miRNA function or expression levels.

The overwhelming majority of the miRNAs are NOT on the X-chromosome, so it is possible that mutations in the miRNA genes can predispose to 20% or more of all schizophrenia.

"While confirmation is required", says Dr Sommer, "this study suggests that microRNA gene mutations can contribute to schizophrenia. If correct, it offers early diagnosis with the promise of subsequent therapy to delay or perhaps even prevent schizophrenia in the subset of patients with miRNA deficiencies".

Says Dr. Rossi, "I am excited by the prospect of using micro RNAs as diagnostic markers for mental illness. It may be feasible to treat schizophrenia by restoring expression of normal microRNAs in the central nervous system with current technologies".

About MEDomics

MEDomics is a molecular diagnostic laboratory founded in 2008 by Steve S. Sommer, MD, PhD, with the mission of providing Mutation Expert-based Diagnosis ("MED") to support the physician in delivering personalized medicine based on analysis of the patient's genome ("omics"). The mutation experts at MEDomics provide unparalleled quality interpretation to aid the practicing physician.

Dr. Sommer is a Founding Fellow of the American College of Medical Genetics with 25 years experience in Clinical Molecular Diagnosis and 300(+ )scientific publications and patents. During the past few years, his neuropsychiatric genetics team helped to define the first genes for which high risk mutations can strongly predispose to schizophrenia or autism. His personalized cancer g
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