Navigation Links
Study Shows a Link Between Schizophrenia & Genetic Mutations
Date:7/20/2009

LOS ANGELES, July 20 /PRNewswire/ -- A link between schizophrenia and ultra-rare variants in microRNA genes on the X-chromosome has been identified. Mutations in a subset of these regulatory RNA genes may strongly predispose to schizophrenia. The recently published study in PLoS ONE by the laboratories of Steve S. Sommer, MD, PhD and John J. Rossi, PhD reports the first association of microRNA dysfunction with schizophrenia. This breakthrough may have preventive or therapeutic implications.

Schizophrenia is a common and devastating brain disease, often presenting in the teens or twenties and affecting about 1% of the population. As affected individuals are typically handicapped for many decades, it is one of the costliest of diseases, roughly comparable with the aggregate cost of a serious cancer. Schizophrenia affects people of all races, ethnic groups, and socioeconomic status, including the economics professor with mild schizophrenia described in the movie "A Beautiful Mind". Some of the homeless population are affected with schizophrenia, as illustrated by the recent movie "The Soloist".

MicroRNAs (miRNA) are a large family of small, non-coding RNAs that down-regulate the expression of a variety of genes and are scattered over the genome. Components required for miRNA processing and/or function have been implicated in X-linked mental retardation, neurological diseases and cancer, suggesting wide ranging involvement of miRNAs in disease.

In this study, the sequences of 59 miRNA genes on the X-chromosome were determined in 193 men with schizophrenia and 191 without the disease. Men were chosen because they are much more commonly affected by mutations in genes on the X-chromosome. Eight ultra-rare variants in eight distinct miRNA genes were detected in 4% of the men with schizophrenia while none were detected in normal men. While 4% may seem to be a small percenta
'/>"/>

SOURCE MEDomics
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine news :

1. Penn study finds pro-death proteins required to regulate healthy immune function
2. New study shows promise in reducing surgical risks associated with surgical bleeding
3. Study, meta-analysis examine factors associated with death from heatstroke
4. Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinsons symptoms
5. Study says COPD testing is not measuring up
6. Preclinical study suggests organ-transplant drug may aid in lupus fight
7. Ability to cope with stress can increase good cholesterol in older white men, study finds
8. High alcohol consumption increases stroke risk, Tulane study says
9. Mailman School of Public Health study examines link between racial discrimination and substance use
10. Pitt study finds inequality in tobacco advertising
11. Stanford study highlights cost-effective method of lowering heart disease risks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/31/2014)... Daily Gossip writes in its Xtreme Fat Loss review ... fat loss program ever developed. It promises to provide users ... is no wonder after all that this has become the ... nutrition and workout fat loss program was created by Joel ... to the author of this fat loss system, the method ...
(Date:10/31/2014)... Oaks, CA (PRWEB) October 31, 2014 ... tummy also has amazing health effects for practitioners. ... created by a Doctor of Science and Movement ... through his dedication to pelvic floor reeducation that ... of urinary incontinence, Diastasis Recti, Prolepses, etc. , ...
(Date:10/31/2014)... 31, 2014 With all the preparations ... optometrist feels they may overlook one critical area – ... like concentration, school performance and even behavior. Typical children’s ... to identify progressive vision problems, and to address this ... a new initiative: The Awesome Eyes Student Vision Program. ...
(Date:10/31/2014)... 31, 2014 Energy Textiles has recently ... new gear is now available online, and Energy Textile ... of Celliant infrared-active athletic gear over compression gear. , ... contract has been signed for Under Armour to provide ... next eight years. In light of this decision, Energy ...
(Date:10/31/2014)... Sleep apnea may make it hard for you to remember ... left your house keys, a small study suggests. Tests ... ability -- called spatial memory -- was impaired when sleep ... stages of sleep weren,t affected. REM sleep is the deepest ... shown for the first time that sleep apnea, an increasingly ...
Breaking Medicine News(10 mins):Health News:Xtreme Fat Loss Diet Review Reveals How to Transform Your Body in 25 Days 2Health News:Super Models and European Celebrities’ Secret Flat Tummy System Comes to America 2Health News:Super Models and European Celebrities’ Secret Flat Tummy System Comes to America 3Health News:New School Vision Initiative Announced by Dr. Rosenak’s Optical Options; Program Aims to Help Recognize Unseen Vision Problems That Impact School Success 2Health News:New School Vision Initiative Announced by Dr. Rosenak’s Optical Options; Program Aims to Help Recognize Unseen Vision Problems That Impact School Success 3Health News:Compression Gear--Is There a Better Alternative? 2Health News:Compression Gear--Is There a Better Alternative? 3Health News:Compression Gear--Is There a Better Alternative? 4Health News:Sleep Apnea May Steal Some of Your Memory: Study 2
... challenges, experts say , , THURSDAY, April 30 (HealthDay News) -- ... health officials are already collecting information and ingredients with an ... though experts say there,s no guarantee such a shot -- ... agree it,s the logical next step. , There are ...
... Study Gives North Dakotans Access to Nursing Home, Assisted Living, ... Every Zip Code StatewideRICHMOND, Va., April 30 The cost ... a rate outpacing inflation, putting significant financial pressure on those ... Genworth Financial. At the same time, the current economic ...
... Study Gives New Hampshire Residents Access to Nursing Home, Assisted ... Nearly Every Zip Code StatewideRICHMOND, Va., April 30 The ... Hampshire is rising at a rate outpacing inflation, putting significant ... an annual study by Genworth Financial. At the same ...
... ANTIOCH, Ill., April 30 The World Health Organization ... April 27th. Meanwhile, health officials around the globe are ... demand for containing infectious disease has never been greater.One ... deadly germs: Intelligent Healthcare Displays. Responding to recommendations from ...
... Birner Dental Management Services, Inc. (Nasdaq: BDMS ... conduct a conference call to review first quarter 2009 results. ... include discussion of management,s expectations of future financial and operating ... 14, 2009 at 9:00 a.m. MT.Dial in to 1-866-283-8244; refer ...
... Residents Access to Nursing Home, Assisted Living, Home Care ... Zip Code StatewideRICHMOND, Va., April 30 The cost ... a rate outpacing inflation, putting significant financial pressure on ... annual study by Genworth Financial. At the same time, ...
Cached Medicine News:Health News:Swine Flu Vaccine Still Months Away 2Health News:Swine Flu Vaccine Still Months Away 3Health News:Growth in North Dakota Long Term Care Costs Outpacing the Rate of Inflation, According to Annual Genworth Financial Study 2Health News:Growth in North Dakota Long Term Care Costs Outpacing the Rate of Inflation, According to Annual Genworth Financial Study 3Health News:Growth in North Dakota Long Term Care Costs Outpacing the Rate of Inflation, According to Annual Genworth Financial Study 4Health News:Growth in New Hampshire Long Term Care Costs Outpacing the Rate of Inflation, According to Annual Genworth Financial Study 2Health News:Growth in New Hampshire Long Term Care Costs Outpacing the Rate of Inflation, According to Annual Genworth Financial Study 3Health News:Growth in New Hampshire Long Term Care Costs Outpacing the Rate of Inflation, According to Annual Genworth Financial Study 4Health News:The Best Defense Against Swine Flu 2Health News:Growth of Long Term Care Costs Outpacing the Rate of Inflation in Minnesota, According to Annual Genworth Financial Study 2Health News:Growth of Long Term Care Costs Outpacing the Rate of Inflation in Minnesota, According to Annual Genworth Financial Study 3Health News:Growth of Long Term Care Costs Outpacing the Rate of Inflation in Minnesota, According to Annual Genworth Financial Study 4
(Date:10/30/2014)... WuXi PharmaTech (Cayman) Inc. (NYSE: WX ), a ... the pharmaceutical, biotechnology, and medical device industries, with operations ... the United States , today announced the establishment ... Aviv area of Israel.  ... integrated R&D services to local customers. It will also ...
(Date:10/30/2014)... Mass. , Oct. 30, 2014 Boston ... to participate in the 2014 Credit Suisse Annual Healthcare ... Phoenix , AZ.  Dan Brennan , executive ... presentation about the company beginning at approximately 8:00 a.m. ... A live webcast of the presentation and question ...
(Date:10/30/2014)... 2014   ViaDerma, Inc. (OTCQB: VDRM), ... products to market, has recently released a revolutionary ... a topical liquid tetracycline-based antibiotic that uses a ... oral medication active ingredients into topical drugs. The ... antibiotic to help prevent skin infection in minor ...
Breaking Medicine Technology:WuXi AppTec Launches Representative Office in Israel, Forms Strategic Collaboration with Pontifax 2Boston Scientific To Participate In 2014 Credit Suisse Annual Healthcare Conference 2ViaDerma, Inc. Lead Product TetraStem Shown Effective in Fighting Staph Infections including MRSA 2ViaDerma, Inc. Lead Product TetraStem Shown Effective in Fighting Staph Infections including MRSA 3
... The cost-effective line of compact CO2 ... units feature an extremely accurate laser beam, ... lasers are especially advantageous for small operating ... office sites. Use of special contact tips ...
... ideal for small clinics and offices. Based ... combines the advantages of laser precision and ... Novapulse system delivers short-duration, high amplitude pulses ... is allowed to cool thus minimizing charring ...
... MD Super Pulse sealed CO2 surgical lasers ... by the experience and support services of ... surgical laser experience. All settings are available ... Ultra MD Super Pulse surgical lasers are ...
... System is a Q-switched 532 Nd Yag ... fluid output, lowering intraocular pressure. The Selecta ... produces a 3-nanosecond high-energy beam of light, ... as traditional argon laser therapy (ALT), but ...
Medicine Products: