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Study Shows Organon's Asenapine Demonstrates Efficacy and Tolerability in Treating Acute Schizophrenia
Date:11/14/2007

ridone) experienced at least one adverse event (AEs) during the study. AEs were generally mild to moderate in severity. The most commonly reported AEs (greater than or equal to 10% of the patients) were: insomnia, somnolence, nausea, anxiety, and agitation in the asenapine group; insomnia, somnolence, anxiety, agitation, and headache in the risperidone group and agitation, headache, anxiety and dizziness in the placebo group. There was no difference between the treatment groups on the incidence of extrapyramidal symptoms. Prolactin levels (greater than or equal to 2 times the laboratory upper limit of normal) were higher in the risperidone group (79%) than in the asenapine or placebo groups (9% and 2%, respectively). Asenapine-treated patients reported a lower rate of clinically significant weight gain (greater than or equal to 7%) versus risperidone-treated patients (4.3% vs. 17%; 1.9% for placebo).

The study, Efficacy and Tolerability of Asenapine in Acute Schizophrenia: A Placebo- and Risperidone-Controlled Trial, is published in the Journal of Clinical Psychiatry (2007;68:1492-1500).

About schizophrenia

Schizophrenia is a chronic, disabling brain disorder characterized by hallucinations, delusions, and disordered thinking. About 24 million people worldwide (or seven in every 1,000 adults in the population) have schizophrenia,(1) including more than two million people in the U.S.(2) and more than four million people in Europe.(3) People with schizophrenia may hear voices other people don't hear or may believe others are trying to harm them. As a result, they may become socially withdrawn, fearful, and agitated.(2)

References

(1) World Health Organization. Available online at:

http://www.who.int/mental_health/management/schizophrenia/en/.

Accessed on October 2, 2007.

(2) National Institute of Mental Health. Availabl
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SOURCE Organon
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