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Study Shows Organon's Asenapine Demonstrates Efficacy and Tolerability in Treating Acute Schizophrenia
Date:11/14/2007

OSS, Netherlands, Nov. 14 /PRNewswire/ -- Asenapine -- a fast- dissolving, sublingual tablet being developed by Organon -- was shown to be effective and well-tolerated in patients with acute schizophrenia, according to a six-week study published in the current issue of the Journal of Clinical Psychiatry. These data were previously presented at the American Psychiatric Association's (APA) annual meeting and at the annual congress of the European College of Neuropsychopharmacology's (ECNP).

In the study, asenapine 5 mg twice daily was significantly more effective than placebo in improving both positive and negative symptoms associated with schizophrenia, based on the Positive and Negative Syndrome Scale (PANSS). This difference was seen starting at the second week of treatment. Positive symptoms include hallucinations and delusions; negative symptoms include lack of emotional expression.

"Currently available atypical antipsychotic drugs like risperidone are effective at reducing hallucinations and other positive symptoms associated with schizophrenia," said Steven G. Potkin, M.D., Department of Psychiatry and Human Behavior, University of California, Irvine. "Asenapine's effect on negative symptoms, as seen in our trial, is an interesting finding."

"These results further confirm asenapine's benefits in schizophrenia, and support our continued confidence in this agent as a potential treatment for this disorder," said Dr. Willem de Laat, executive vice president, medical affairs, Organon.

About the Study

In the study, 174 patients with schizophrenia were randomized to asenapine 5 mg twice daily, risperidone 3 mg twice daily, or placebo for six weeks. Asenapine was more effective than placebo in reducing total PANSS score as well as positive symptoms and negative symptoms when measured alone. Risperidone was more effective than placebo in reducing positive symptoms.

The majority of patients (83% asenapine, 79% placebo, 90% rispe
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SOURCE Organon
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