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Study Shows MammaPrint(R) Breast Cancer Test Provides Benefits to Patients from Personalized Treatment Regimen
Date:12/14/2007

ing unnecessary treatment," said Dr Laura van 't Veer, chief research officer at Agendia, who participated in the study.

According to the results in The Lancet Oncology, adjuvant chemotherapy was advised less often when the patient's prognosis was based on the DUTCH CBO Guidelines -- which are considered the most restrictive -- compared with assessments based on MammaPrint(R). For the other guidelines assessed, however, less adjuvant therapy would be given based on the prognosis of MammaPrint(R). These results confirm previous findings and validations with the test.

"These data provide important information to patients and physicians that can effectively help guide treatment decisions in community-based hospitals. The prognosis provided by MammaPrint(R), together with guidance from clinical guidelines and patients' treatment preferences, are vital tools for physicians caring for breast cancer patients," said Bernhard Sixt, chief executive officer at Agendia.

About MammaPrint(R)

MammaPrint(R) laboratory service is the first and only FDA cleared (February 2007) DNA microarray-based 'in vitro diagnostic multivariate index assay' (IVDMIA). MammaPrint(R) measures the activity of 70 genes, providing information about the likelihood of tumor recurrence. The MammaPrint(R) test measures the level of expression of each of these genes in a sample of a woman's surgically-removed breast cancer tumor and then uses a specific formula or algorithm to produce a score that determines whether the patient is deemed low risk or high risk for spread of the cancer to another site. The result may help a doctor in planning treatment and appropriate follow-up for a patient when used with other clinical information and laboratory tests. All MammaPrint(R) tests are conducted in Agendia's CLIA-certified central service laboratory.

About Agendia

Agendia, located in Amsterdam, The Netherlands, is a world leader in gene expression analysis-based diagnostic
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SOURCE Agendia
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