Navigation Links
Study Shows MammaPrint(R) Breast Cancer Test Provides Benefits to Patients from Personalized Treatment Regimen
Date:12/14/2007

- New Lancet Oncology publication provides important insights on the use of

MammaPrint(R) Breast Cancer Prognosis Test in clinical practice -

AMSTERDAM, The Netherlands, Dec. 14 /PRNewswire/ -- New research demonstrates that the MammaPrint(R) breast cancer prognosis test was successfully implemented in the diagnostic process of breast cancer patients in community hospitals in The Netherlands. MammaPrint(R) assigned up to one- third of the patients to different risk categories as compared to currently used risk assessment tools. In the majority of these situations, it may lead to a reduction in the use of adjuvant chemotherapy. The findings were published in the December issue of The Lancet Oncology.

In the study, breast tumors from 585 patients with lymph node-negative, invasive breast cancer, collected at 16 hospitals in The Netherlands. Fresh samples were shipped in RNAretain(R)* at ambient temperature and were subjected at Agendia Laboratories to MammaPrint(R) gene expression analysis. Results were available for 427 patients. Based on this, patients were classified as having either a poor prognosis (high risk for distant metastasis) or good prognosis (low risk for metastasis). These results were then compared by the study coordinators to risk assessments of commonly used guidelines, including the Dutch Institute for Health Improvement (Dutch CBO) Guidelines, St. Gallen Guidelines, Nottingham Prognostic Index, and Adjuvant! Online. Many guidelines use algorithms (based on the patient's age, tumor size, and node status) to determine a patient's prognosis and determine whether or not patients should receive chemotherapy.

"More than 70 percent of patients who have node-negative breast cancer are successfully treated without chemotherapy. Identifying which patients with breast cancer will most likely require adjuvant chemotherapy is an important step in personalizing a patient's treatment regimen, and ensuring that patients aren't receiving unnecessary treatment," said Dr Laura van 't Veer, chief research officer at Agendia, who participated in the study.

According to the results in The Lancet Oncology, adjuvant chemotherapy was advised less often when the patient's prognosis was based on the DUTCH CBO Guidelines -- which are considered the most restrictive -- compared with assessments based on MammaPrint(R). For the other guidelines assessed, however, less adjuvant therapy would be given based on the prognosis of MammaPrint(R). These results confirm previous findings and validations with the test.

"These data provide important information to patients and physicians that can effectively help guide treatment decisions in community-based hospitals. The prognosis provided by MammaPrint(R), together with guidance from clinical guidelines and patients' treatment preferences, are vital tools for physicians caring for breast cancer patients," said Bernhard Sixt, chief executive officer at Agendia.

About MammaPrint(R)

MammaPrint(R) laboratory service is the first and only FDA cleared (February 2007) DNA microarray-based 'in vitro diagnostic multivariate index assay' (IVDMIA). MammaPrint(R) measures the activity of 70 genes, providing information about the likelihood of tumor recurrence. The MammaPrint(R) test measures the level of expression of each of these genes in a sample of a woman's surgically-removed breast cancer tumor and then uses a specific formula or algorithm to produce a score that determines whether the patient is deemed low risk or high risk for spread of the cancer to another site. The result may help a doctor in planning treatment and appropriate follow-up for a patient when used with other clinical information and laboratory tests. All MammaPrint(R) tests are conducted in Agendia's CLIA-certified central service laboratory.

About Agendia

Agendia, located in Amsterdam, The Netherlands, is a world leader in gene expression analysis-based diagnostics with three products on the market. The company focuses on the development and commercialization of diagnostic tests using tumor gene expression profiling. Agendia was the first company to commercialize a prognostic test -- MammaPrint(R) -- that predicts the risk of breast cancer recurrence. Agendia maintains close ties with several leading academic centers to develop state of the art diagnostic tests for cancer. Agendia also offers its expertise to pharma companies focusing on development of highly effective personalized drugs in the area of oncology. For more information on Agendia, please visit http://www.agendia.com.

* RNARetain(R) is a trademark of Asuragen Inc.


'/>"/>
SOURCE Agendia
Copyright©2007 PR Newswire.
All rights reserved

Related medicine news :

1. Penn study finds pro-death proteins required to regulate healthy immune function
2. New study shows promise in reducing surgical risks associated with surgical bleeding
3. Study, meta-analysis examine factors associated with death from heatstroke
4. Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinsons symptoms
5. Study says COPD testing is not measuring up
6. Preclinical study suggests organ-transplant drug may aid in lupus fight
7. Ability to cope with stress can increase good cholesterol in older white men, study finds
8. High alcohol consumption increases stroke risk, Tulane study says
9. Mailman School of Public Health study examines link between racial discrimination and substance use
10. Pitt study finds inequality in tobacco advertising
11. Stanford study highlights cost-effective method of lowering heart disease risks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2017)... ... May 26, 2017 , ... Amir Qureshi, MD is ... powerfully versatile, patient-centric spinal cord stimulation system. The Nuvectra™ Algovita SCS System has been ... pleased to be the first in Arkansas to introduce the most powerful SCS system ...
(Date:5/26/2017)... ... ... A new analysis of community health data reveals that four out of ... With the average cost of healthcare rising and the U.S. senior population expected to ... affordability of where they live. An annual 2017 report looked at a variety of ...
(Date:5/26/2017)... ... 2017 , ... via seating is proud to partner with ... specifically designed for clinical areas. Genie Copper Mesh is a crossover chair for ... provide customers with a game changing chair that is affordably priced,” Chas Hepler ...
(Date:5/26/2017)... ... May 26, 2017 , ... After raising nearly $30,000 on ... will continue to be available at a discounted crowdfunding price on Indiegogo . ... they are, I also wanted to bring a fidget toy to the market that ...
(Date:5/26/2017)... (PRWEB) , ... May 26, 2017 , ... Silver Birch ... community, which is located on more than four acres of land at 5620 Sohl ... , The 103,000 square-foot building includes 125 studio and one-bedroom apartments. Each of ...
Breaking Medicine News(10 mins):
(Date:5/10/2017)... Inc. (Nasdaq: HOLX ) announced today the ... April 1, 2017 .   GAAP diluted earnings per ... prior year period as the sale of the blood ... diluted EPS of $0.50 increased 6.4%.  Revenue of $715.4 ... Excluding the effects of blood screening and the acquired ...
(Date:5/9/2017)... 2017 Zimmer Biomet Holdings, Inc. (NYSE and ... announced it has earned a spot on Forbes, ... Company was ranked among 500 U.S. employers as well ... Equipment and Services. The annual Forbes ... independent survey of over 30,000 employees across 25 industries. ...
(Date:5/8/2017)... , May 8, 2017  Diplomat Pharmacy, Inc. (NYSE: ... Inc. ("WRB"), a health care service center company ... WRB specializes in relationship management programs for leading ... WRB will join Envoy ... support services for manufacturers, biotech firms, and other service ...
Breaking Medicine Technology: