Navigation Links
Study Showing Improved Virologic Response with Nitazoxanide in Chronic Hepatitis C Published in Gastroenterology
Date:3/2/2009

ide plus peginterferon for an additional 36 weeks (n = 28);
  • Nitazoxanide monotherapy for 12 weeks followed by nitazoxanide plus both peginterferon and ribavirin for 36 weeks (n = 28).

    • The primary endpoint was sustained virological response (SVR), or serum HCV RNA <12 IU/mL 24 weeks after the end of treatment. Secondary endpoints included HCV RNA <12 IU/mL at week 4 (rapid virological response, or RVR), at week 12 (complete early virological response, cEVR), and at the end-of-treatment (ETR).

    Results

    The percentages of patients with RVR, defined as undetectable serum HCV RNA at week 4 of combination therapy, and SVR were significantly higher in patients given the triple therapy compared with the standard of care (64% versus 38%, p=0.048 and 79% versus 50%, p=0.023, respectively). Patients given nitazoxanide plus peginterferon alfa-2a had intermediate rates of RVR (54%) and SVR (61%). Adverse events were similar across treatment groups except for a higher rate of anemia in the groups receiving ribavirin. In the nitazoxanide group, virologic responses were maintained through the end of treatment with no virologic breakthroughs. Of note, the use of nitazoxanide was associated with reduced relapse rates (3/20 patients in the peginterferon plus nitazoxanide arm, and 1/23 patients in the triple arm with peginterferon, ribavirin and nitazoxanide) versus 10/30 patients in the standard-of-care arm.

    About Nitazoxanide and Hepatitis C

    Nitazoxanide, the first of a new class of broad spectrum antiviral drugs known as the thiazolides, is undergoing worldwide development as a treatment of chronic hepatitis C. Nitazoxanide is a potent inhibitor of hepatitis C virus (HCV) replication in HCV genotype 1-derived replicon cell lines, and in vitro studies have shown that it does not induce mutations in the virus that confer resistance. Phase II clinical trials
    '/>"/>

    SOURCE Romark Laboratories
    Copyright©2009 PR Newswire.
    All rights reserved

    1

    GOOD

    Page: 1 2 3 4

    Related medicine news :

    1. Penn study finds pro-death proteins required to regulate healthy immune function
    2. New study shows promise in reducing surgical risks associated with surgical bleeding
    3. Study, meta-analysis examine factors associated with death from heatstroke
    4. Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinsons symptoms
    5. Study says COPD testing is not measuring up
    6. Preclinical study suggests organ-transplant drug may aid in lupus fight
    7. Ability to cope with stress can increase good cholesterol in older white men, study finds
    8. High alcohol consumption increases stroke risk, Tulane study says
    9. Mailman School of Public Health study examines link between racial discrimination and substance use
    10. Pitt study finds inequality in tobacco advertising
    11. Stanford study highlights cost-effective method of lowering heart disease risks
    Post Your Comments:
    *Name:
    *Comment:
    *Email:
    (Date:5/24/2013)... With Memorial Day Weekend upon us, cookout season has officially ... to help prevent grill fires throughout the spring and summer. ... that gas grills led to an average of 7,100 home ... meanwhile, caused approximately 1,200 home fires per year during that ... the following tips from the NFPA to help protect your ...
    (Date:5/24/2013)... Calif.) (PRWEB) May 24, 2013 ... House Appropriators and the California congressional delegation, joined ... restore sequestered industry user fees paid to the ... to ensure that future across-the-board cuts will not ... of the FY14 Agriculture, Rural Development and FDA ...
    (Date:5/24/2013)... 2013 Let’s face it: very few are ... for the majority of people to be uncomfortable with the ... a coffee addiction or simply genetics, yellowish or stained teeth ... popular. , Herald Square Dental is proud to ... system: Venus White Max. , Teeth become discolored for ...
    (Date:5/24/2013)... The nation’s first trial of a ... da Vinci Surgical System concluded yesterday, Bernstein Liebhard LLP ... Court jury ruled in a 10-to-2 decision that Intuitive ... performed a da Vinci prostatectomy on a patient who ... alleged in their lawsuit that the da Vinci complications ...
    (Date:5/24/2013)... May 24, 2013 BestSatelliteProviders.com the ... helped thousands of consumers compare the features and ... reviews site recently released the rankings of the ... are available for viewing on their website. ... , According to Adam Matthews, the spokesperson for ...
    Breaking Medicine News(10 mins):Health News:Don’t Get Burned: Five Grilling Tips from Amica Insurance 2Health News:California Biomedical Industry Leaders Urge Congress to Take Action on FDA User Fees for FY2014 2Health News:California Biomedical Industry Leaders Urge Congress to Take Action on FDA User Fees for FY2014 3Health News:Herald Square Dental Introduces New In-office Whitening System: Venus White Max 2Health News:Da Vinci Robot Lawsuit News: Bernstein Liebhard LLP Comments on Verdict in Nation’s First Trial Involving Alleged Da Vinci Complications 2Health News:Da Vinci Robot Lawsuit News: Bernstein Liebhard LLP Comments on Verdict in Nation’s First Trial Involving Alleged Da Vinci Complications 3Health News:Best Rural Internet Service Provider in 2013 by BestSatelliteProviders.com 2
    ... ... 2008 SpeechNutrients introduced the supplement NourishLife speak™ which combines omega-3 and ... speech challenges. A recent study published in the July issue ... with verbal apraxia taking a combination of omega-3 and vitamin E ...
    ... ... Dysport. Dysport is the first rival for Botox. Dr. Pilest met with Medicis CEO Jonah ... who were involved in FDA trials for Dysport. , ... Irvine, CA (PRWEB) August 13, 2009 -- Dr. Nissan Pilest was ...
    ... , FRANKLIN LAKES, N.J. and LONDON, ... ), the world,s most advanced pharmacy(R) , today extended its ... with United Drug plc, a Pan-European healthcare leader, to provide home-based ... the country,s National Health Service (NHS). The NHS provides healthcare ...
    ... SILVER SPRING, Md., Aug. 12 The Association ... million in first-year funding through the President,s Emergency Plan ... laboratories and laboratory systems in participating countries. The five-year ... Centers for Disease Control and Prevention (CDC) will support ...
    ... survivors who lift weights are less likely than their ... arm- and hand-swelling condition that plagues many women following ... Pennsylvania School of Medicine research published in the August ... Medicine . The findings challenge the advice commonly given ...
    ... , , CHICAGO, Aug. 12 ... comments President Obama continues to make about the high-quality care provided by ... incorrect or not based in fact, we think he does a disservice ... facts about health care reform. We want to set the record ...
    Cached Medicine News:Health News:Newly Published Research Indicates 97% of Apraxic Children Improving with Novel Nutritional Combination 2Health News:Newly Published Research Indicates 97% of Apraxic Children Improving with Novel Nutritional Combination 3Health News:Newly Published Research Indicates 97% of Apraxic Children Improving with Novel Nutritional Combination 4Health News:Orange County Derm Nissan Pilest Selected to Become Physician Trainer for Dysport 2Health News:Orange County Derm Nissan Pilest Selected to Become Physician Trainer for Dysport 3Health News:Medco Health Solutions, United Drug Announce U.K. Homecare Pharmacy Joint Venture Serving Patients with Chronic and Complex Health Conditions; Innovations to Improve Clinical Quality, Reduce Costs 2Health News:Medco Health Solutions, United Drug Announce U.K. Homecare Pharmacy Joint Venture Serving Patients with Chronic and Complex Health Conditions; Innovations to Improve Clinical Quality, Reduce Costs 3Health News:APHL Chosen by PEPFAR to Develop Global Health Laboratory Systems 2Health News:Lifting weights reduces lymphedema symptoms following breast cancer surgery, Penn research shows 2Health News:Lifting weights reduces lymphedema symptoms following breast cancer surgery, Penn research shows 3Health News:Statement from the American College of Surgeons Regarding Recent Comments from President Obama 2
    (Date:5/24/2013)...  An international roster of experts on malignant pleural ... Santa Monica, Calif. , to discuss their ... a rare form of cancer that results from exposure ... of the chest. Hosted by UCLA and ... Annual International Symposium on Lung-Sparing Therapies for Malignant Pleural ...
    (Date:5/24/2013)... NEW YORK , May 24, 2013 In ... Takeover Rules and Rule 14e-1 of the United States Exchange ... levels its original offer for Elan Corporation (NYSE: ELN). ... Acquisition Limited ("Royalty Pharma") made an offer for the entire ... Elan Corporation, plc ("Elan") (the "Original Offer").  ...
    (Date:5/23/2013)... 24, 2013 3SBio Inc. (NASDAQ: ... leading China -based biotechnology company ... products, announced today that, at an extraordinary general ... voted in favor of the proposal to authorize ... of merger dated February 8, 2013, among Decade ...
    Breaking Medicine Technology:International Mesothelioma Experts Present Promising New Research Findings at the 3rd Annual International Symposium on Lung-Sparing Therapies for Malignant Pleural Mesothelioma 2International Mesothelioma Experts Present Promising New Research Findings at the 3rd Annual International Symposium on Lung-Sparing Therapies for Malignant Pleural Mesothelioma 3Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements 2Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements 3Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements 4Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements 5Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements 6Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements 7Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements 8Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements 93SBio Inc. Announces Shareholders' Approval of the Amended Merger Agreement 23SBio Inc. Announces Shareholders' Approval of the Amended Merger Agreement 3
    ... Presented at 2007 APA Meeting -, COLLEGEVILLE, ... four new studies examining safety and efficacy ... studied as a potential treatment for adults,with ... at the,2007 American Psychiatric Association annual meeting ...
    ... Childhood Condition, WASHINGTON, May 22, 2007 /PRNewswire-FirstCall/ ... pediatric patients,with gastroesophageal reflux disease (GERD) during ... Disease Week meeting held at the,Washington Convention ... support AstraZeneca's,commitment to research in the area ...
    Cached Medicine Technology:New Study Results Provide Additional Data about Short- and,Long-Term Use of Desvenlafaxine Succinate in the Treatment of,Adults with Major Depressive Disorder 2New Study Results Provide Additional Data about Short- and,Long-Term Use of Desvenlafaxine Succinate in the Treatment of,Adults with Major Depressive Disorder 3New Study Results Provide Additional Data about Short- and,Long-Term Use of Desvenlafaxine Succinate in the Treatment of,Adults with Major Depressive Disorder 4New Study Results Provide Additional Data about Short- and,Long-Term Use of Desvenlafaxine Succinate in the Treatment of,Adults with Major Depressive Disorder 5New Study Results Provide Additional Data about Short- and,Long-Term Use of Desvenlafaxine Succinate in the Treatment of,Adults with Major Depressive Disorder 6New Study Results Provide Additional Data about Short- and,Long-Term Use of Desvenlafaxine Succinate in the Treatment of,Adults with Major Depressive Disorder 7New Study Results Provide Additional Data about Short- and,Long-Term Use of Desvenlafaxine Succinate in the Treatment of,Adults with Major Depressive Disorder 8New Studies Evaluating NexiumIn Pediatric GERD To Be Presented At,Annual Digestive Disease Week Meeting 2New Studies Evaluating NexiumIn Pediatric GERD To Be Presented At,Annual Digestive Disease Week Meeting 3New Studies Evaluating NexiumIn Pediatric GERD To Be Presented At,Annual Digestive Disease Week Meeting 4New Studies Evaluating NexiumIn Pediatric GERD To Be Presented At,Annual Digestive Disease Week Meeting 5
    ... order tips. Each box contains 10,000 tips ... in easy-to-open, re-sealable Bulk Packs of 200 ... with a tamper-proof strip which can easily ... Diamond Tips. Bulk Packs are closed using ...
    Capillary section fits into a 0.3-mm well for accurate loading of sequencing gels - Ideal for use with CastAway System...
    This extended 10 ul combats contamination by keeping your pipettor out of 1.5 ul and 2.0 ul tubes. Utilizes MicroPoint design and 2 ul reference mark....
    ... powerful motor with a lightweight, comfortable design. ... three positions for maximum comfort and convenience.mum ... button on the top of the filler ... wide-angle position is ideal for restricted spaces ...
    Medicine Products: