Navigation Links
Study Sees Link Between Epilepsy, Infertility

MONDAY, Oct. 11 (HealthDay News) -- Women with epilepsy may be at increased risk of infertility, a study of women from India suggests.

The study included 375 women who planned to have a child, average age 26, who were followed until they became pregnant or for up to 10 years. During the study period, 62 percent of the women became pregnant.

The rate of infertility among women with epilepsy was more than twice the 15 percent rate in the general population. Women taking three or more drugs for epilepsy were 18 times more likely to be infertile than those taking no epilepsy drugs -- 60 percent versus 7 percent. Infertility rates were 41 percent for women taking two epilepsy drugs and 32 percent for those taking one epilepsy drug, the study authors found.

"This may be due to the adverse effects of taking multiple drugs or it could be a more indirect effect because people who are taking multiple drugs are more likely to have severe epilepsy that is difficult to treat," study author Sanjeev Thomas, of the Sree Chitra Tirunal Institute for Medical Sciences and Technology in Trivandrum, India, said in a news release from the American Academy of Neurology.

The researchers found that the drug phenobarbital was associated with significant risk of infertility, while no such link was noted with valproate or other drugs.

The study findings are published in the Oct. 12 print issue of the journal Neurology.

"Based on these findings, women with epilepsy should be counseled about the potential risk of infertility and referred for an evaluation if they have not conceived within two years" of trying to become pregnant, Dr. Alison M. Pack, an assistant professor of clinical neurology at Columbia University in New York City, wrote in an accompanying editorial in the journal.

Dr. Steven V. Pacia, director of the Comprehensive Epilepsy Center at Lenox Hill Hospital in New York City, said: "Certain antiepileptic medications (AEDs), including phenobarbital, may affect the metabolism of normal hormones in women with epilepsy. This effect will be enhanced at higher doses and by the addition of several other AEDS that may be expected in patients with more severe epilepsy.

"However, patients with more severe epilepsy can be expected to have a higher incidence of cognitive problems, mood disorders and hyposexuality, which may also lead to higher rates of infertility," he added.

More information

The U.S. National Women's Health Information Center has more about infertility.

-- Robert Preidt

SOURCES: American Academy of Neurology, news release, Oct. 11, 2010; Lenox Hill Hospital, news release, Oct. 11, 2010

Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Despite Treatment, Employees with Depression Generate Higher Absentee Costs, According to Thomson Reuters Study
2. American Council on Exercise (ACE) Study Reveals Kettlebells Provide Powerful Workout in Short Amount of Time
3. TV drama can be more persuasive than news program, study finds
4. Study carried out into biological risks of eating reptiles
5. Neuroimaging study may pave way for effective Alzheimers treatments
6. Study finds racial gaps continue in heart disease awareness
7. Luth Researchs IndicatorEDG(TM) Study Finds Americans Hopes of Achieving Their Dreams Are Fading
8. First blinded study of venous insufficiency prevalence in MS shows promising results
9. Soothing infants with food focus of childhood obesity study
10. People with anxiety disorder less able to regulate response to negative emotions, study shows
11. American Heart Association Rapid Access Journal Report: Study Finds Racial Gaps Continue in Heart Disease Awareness, Low Knowledge of Heart Attack Warning Signs Among Women
Post Your Comments:
(Date:11/27/2015)... ... November 27, 2015 , ... An inventor, ... to dispense prescription medications at home, so he invented the patent-pending ELECTRONIC M.D. ... dispense prescription medications. In doing so, it could help to prevent potential overdose ...
(Date:11/27/2015)... ... November 27, 2015 , ... The ... of USA Today in Atlanta, Dallas, New York, Minneapolis, South Florida, with a ... component is distributed nationally, through a vast social media strategy and across a ...
(Date:11/27/2015)... ... November 27, 2015 , ... Consistent with ... the 2016 Building Better Radiology Marketing Programs meeting will showcase some ... March 6, 2016, at Caesars Palace in Las Vegas with a pre-conference session ...
(Date:11/27/2015)... (PRWEB) , ... November 27, 2015 , ... ... failing. Secura Consultants has prided itself for not only fulfilling the needs of ... protection solutions at an affordable price and providing top-tier customer service. However, there's ...
(Date:11/27/2015)... ... November 27, 2015 , ... The men and ... nonprofit healthcare organizations in the country. They have overseen financial turnarounds, shown commitment ... advance the healthcare industry as a whole through their advocacy and professional efforts. ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... India , November 26, 2015 ... --> adds ... Report" and "Investigation Report on China ... and 2021 forecasts data and information ... . ...
(Date:11/26/2015)... 2015 ) ... "Radioimmunoassay Market by Type (Reagents & Kits, ... Clinical Diagnostic Labs), Application (Research, Clinical Diagnostics), ... report to their offering. --> ... of the "Radioimmunoassay Market by Type ...
(Date:11/25/2015)... , Nov. 26, 2015  The total global healthcare industry ... over 2015-2016. Latin America has the ... , (excluding Japan ), is second with ... continues to face increased healthcare expenditure. In 2013-2014, total government ... from 43.5% in 2008-2009 to 41.2% in 2013-2014. In real ...
Breaking Medicine Technology: