Navigation Links
Study Questions Dead-End Cancer Clinical Trials
Date:9/10/2007

Just 13% of 'positive' phase II studies go forward despite promise

MONDAY, Sept. 10 (HealthDay News) -- Little more than one in eight phase II cancer clinical trials with encouraging results go forward to the larger, phase III stage that's needed to bring a new therapy to patients, a new study finds.

In many cases, the researchers conducting the phase II effort knew beforehand that, due to financial or other constraints, a phase III trial was unlikely.

According to experts, that raises the troubling question of why the phase II study was done at all.

"If all of this effort in supporting phase II trials doesn't go anywhere, it means that the patients included -- and the efforts of their doctors -- could have been spent in finishing potentially practice-changing phase III studies," said the study's lead author, Ian Tannock, professor of medical oncology at Princess Margaret Hospital and the University of Toronto, Canada.

The bench-to-bedside evolution of any new cancer treatment occurs in three stages once a drug clears animal testing. First, a small phase I trial assesses the therapy's safety and calibrates the best dose. Next, a phase II trial (usually less than 100 patients) looks at how effective the therapy might be against a particular type of tumor.

If those results are positive, the drug should next go on to a much larger -- and expensive -- randomized trial comparing the new agent against the current standard of care. Positive results from phase III trials are required for U.S. Food and Drug Administration approval of most new agents.

Given the scarcity of both money and willing volunteers for cancer research, "a phase II trial shouldn't even be started unless there is an intention -- if the phase II results look promising -- to take it forward," said Tannock, who presented the study findings in June at the American Society of Clinical Oncology annual meeting.

And y
'/>"/>

Copyright©2007 ScoutNews,LLC.
All rights reserved

Page: 1 2 3 4 5

Related medicine news :

1. Gene study links endometriosis, infertility
2. Study reveals how stress can make you sick
3. Study points out that HIV vaccine may not be accepted easily
4. A new study surpasses Gene Therapy Hurdle
5. Tomato Sauce reduces Cancer Risk- Study
6. A question on study of Adult Stem Cell
7. Study on obesity and heart failure
8. National Lung Study in the process
9. Marijuana gateway theory strengthened by study of twins
10. Old theory of adaptation confirmed by new study
11. Study casts doubt on keyboard ills
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2014)... Fancyflyingfox.com, the well-known wedding dress manufacturer and retailer, has recently ... dresses . In addition, the company has also deiced to ... Each item in the new range is now provided with ... The company has thousands of unique special occasion outfits for ... affordable prices. Its products are brand new and made with ...
(Date:9/21/2014)... the birth of an infant prior to 37 ... that has increased over the past two decades. ... (CDC), preterm birth affects nearly 500,000 babies each year, ... While medical care has improved survival rates for preterm ... neurodevelopmental outcomes of preterm infants. , Research led by ...
(Date:9/21/2014)... UNIWIGS, one of the leading online stores of real ... a line of human hair lace wigs inspired by 6 ... people what the latest celebrity hairstyles are. , ... 4 different hairstyles to choose from: a style of yaki ... and a hot ombre red lace wig. People can go ...
(Date:9/21/2014)... authorities focus on the physical activity benefits of active ... reveals that for children, playing has no goal ... is fun, done alone or with friends, and it ... also to combat boredom, sadness, fear, or loneliness." "By ... put aside several aspects of play that are beneficial ...
(Date:9/21/2014)... peanuts are more likely to trigger an allergy to ... involving mice. , The researchers say that specific chemical ... roasting process are recognised by the body,s immune system, ... response the next time it sees any peanuts. , ... of people with peanut allergies in the Western world ...
Breaking Medicine News(10 mins):Health News:Discounted Plus Size Wedding Dresses Available At Fancyflyingfox.com 2Health News:Research evaluates neurodevelomental and medical outcomes in single family room NICU 2Health News:Research evaluates neurodevelomental and medical outcomes in single family room NICU 3Health News:UniWigs New Arrivals Just In- Human Hair Lace Wigs Inspired By Famous Celebrities 2Health News:Narrow focus on physical activity could be ruining kids' playtime 2Health News:Dry roasting could help trigger peanut allergy 2
... ... brought another family together for the holidays , ... (PRWEB) December 31, 2009 -- Celebrating the holidays under the grip of ... story evoking the true spirit of the holidays. "Before he began using drugs like ...
... ... year right , ... (PRWEB) -- Massage Envy , the nation’s largest massage therapy provider, recommends ringing in ... program. Along with resolving to eat healthier, take vitamins and exercise more frequently, incorporating ...
... a little extra incentive to kick the habit? Just ... that even after age 80, smoking continues to increase one,s ... blindness in Americans over 65. The ... January edition. "The take-home message is that it,s never ...
... , GAINESVILLE, Fla., ... the delegation at the Florida House on Capitol Hill in Washington, ... efforts to establish a gallery and learning center in Ft. Myers, ... while bridging differences and strengthening relationships. , (Photo: ...
... of the Streptococcus pneumoniae in samples that ... may predict risk of severe disease in H1N1 pandemic ... associated with higher morbidity and mortality than in other ... Immunity (CII) at the Mailman School of Public Health ...
... , , , , WOONSOCKET, ... will provide H1N1 flu vaccinations at select CVS/pharmacy ... and New York as well at MinuteClinic locations in Massachusetts ... ) , Public health officials are now encouraging everyone ...
Cached Medicine News:Health News:Mother and Son Spend Holidays Free of Drug Addiction 2Health News:Ring in a Healthy New Year with Massage Therapy in 2010 2Health News:It's never too late to quit smoking and save your vision 2Health News:Founders of the Sebastian Ferrero Foundation Join HSH Prince Albert II of Monaco in Support of the New Art of the Olympians Museum 2Health News:Founders of the Sebastian Ferrero Foundation Join HSH Prince Albert II of Monaco in Support of the New Art of the Olympians Museum 3Health News:Founders of the Sebastian Ferrero Foundation Join HSH Prince Albert II of Monaco in Support of the New Art of the Olympians Museum 4Health News:Severity of H1N1 influenza linked to presence of Streptococcus pneumoniae 2Health News:CVS/pharmacy and MinuteClinic to Provide H1N1 Vaccines in 8 New States 2Health News:CVS/pharmacy and MinuteClinic to Provide H1N1 Vaccines in 8 New States 3Health News:CVS/pharmacy and MinuteClinic to Provide H1N1 Vaccines in 8 New States 4
(Date:9/19/2014)... Conn. , Sept. 19, 2014 UBM ... , a leading online community to help oncologists and ... information available regarding the use of targeted therapies and ... cancer research and treatment.  Every September, ... a way to raise awareness about blood cancers—helping to ...
(Date:9/19/2014)... 19, 2014  Alere Inc. (NYSE: ALR ... following statement today in support of President Barack ... "As the global leader in rapid diagnostics for infectious ... strategy to address the serious threat of antibiotic resistance. ... Administration on initiatives to promote the development of rapid ...
(Date:9/19/2014)... ORLANDO, Fla. , Sept. 19, 2014 /PRNewswire/ ... to grow, with the publication of two papers this ... Otolaryngology – Head and Neck Surgery , ... both objective and subjective measures of sleep disordered breathing, ... for the reduction in obstructive sleep apnea severity and ...
Breaking Medicine Technology:OncoTherapy Network Highlights National Blood Cancer Awareness Month 2OncoTherapy Network Highlights National Blood Cancer Awareness Month 3OncoTherapy Network Highlights National Blood Cancer Awareness Month 4Alere Applauds President's Executive Order Combating Antibiotic-Resistant Bacteria 2New Data shows Reductions in obstructive sleep apnea (OSA) severity and improvement of quality of life with Inspire therapy 2New Data shows Reductions in obstructive sleep apnea (OSA) severity and improvement of quality of life with Inspire therapy 3New Data shows Reductions in obstructive sleep apnea (OSA) severity and improvement of quality of life with Inspire therapy 4
... 14, 2011 WaferGen Biosystems, Inc. (OTC Bulletin Board: ... systems, today reported financial results for the three months and ... revenue growth in 2010 to a total of $2.2 million ... $1.5 to $2 million for the year," said Alnoor Shivji, ...
... Inc. (Nasdaq: BNVI ) announced today that it will ... ended December 31, 2010 on Tuesday, March 15, 2011. The Company ... results on Tuesday, March 15, 2011, at 5:30 p.m. ET. ... can listen via a live audio only webcast, which can be ...
Cached Medicine Technology:WaferGen Reports Fourth Quarter and Full Year 2010 Financial Results 2WaferGen Reports Fourth Quarter and Full Year 2010 Financial Results 3WaferGen Reports Fourth Quarter and Full Year 2010 Financial Results 4WaferGen Reports Fourth Quarter and Full Year 2010 Financial Results 5WaferGen Reports Fourth Quarter and Full Year 2010 Financial Results 6WaferGen Reports Fourth Quarter and Full Year 2010 Financial Results 7WaferGen Reports Fourth Quarter and Full Year 2010 Financial Results 8
... closes various plastic primary and secondary tubes in ... heights and diameters can be sealed in one ... send-outs. The integration into other PVT Systems (e.g. ... and High Throughput Sorter RSD ProVolume ) ...
... MGB Alert Detection Reagents provide molecular ... PCR based assays. By using our MGB ... analysis, Nanogen is now able to provide ... nucleic acid sequences of specific organisms or ...
... for the detection of two genetic ... mutation on the Factor V (Leiden) ... the Prothrombin gene. Laboratories may use ... *Analyte Specific Reagents. Analytical ...
... the latest and most advanced fecal occult ... line. An immunochemical FOBT (iFOBT) with high ... proven to detect bleeding associated with more ... Because of its superior specificity for lower ...
Medicine Products: