Navigation Links
Study Probes Potential Link Between Welding, Parkinson's Disease
Date:4/6/2011

WEDNESDAY, April 6 (HealthDay News) -- Manganese in welding fumes may affect welders' brains over time, according to a new, small study.

Previous research has found a link between manganese and neurological disorders, including Parkinson's disease-like symptoms.

This study included 20 welders with no symptoms of Parkinson's disease, 20 Parkinson's disease patients who were not welders, and 20 healthy people who were not welders. The welders worked at shipyards and a metal fabrication plant in the Midwest and had an average of 30,000 hours of lifetime welding exposure. Their average manganese levels were two times the upper limits of normal.

All 60 participants underwent brain PET and MRI scans and motor skills tests, and were examined by a movement disorder specialist.

Compared to non-welders, the welders had an average 11.7 percent reduction in a marker of the neurotransmitter dopamine in the same area of the brain affected by Parkinson's disease. Dopamine helps nerve cells communicate.

The researchers also found that welders had mild movement disorders. However, the results merely show an association, not cause and effect.

"There are over one million workers who perform welding as part of their job functions in the United States," study author Dr. Brad A. Racette of the Washington University School of Medicine in St. Louis said in a journal news release. "If a link between neurotoxic effects and these fumes were proven, it would have a substantial public health impact for the U.S. workforce and economy," he said.

But one expert said it's too early to draw firm conclusions from the study.

"The dopaminergic reductions [observed] were not as dramatic as those seen in Parkinson's disease patients nor was the nature of the reduction exactly like that typically seen in Parkinson's," said Dr. Michael Pourfar, director of the division of movement disorders at North Shore-LIJ Health System, Great Neck, NY. He agreed that right now, all the findings suggest is an association with dopamine function.

"That is to say, exposure to manganese may affect dopamine function and cause a parkinsonian syndrome but it does not clearly cause the same classic Parkinson's that most people are familiar with," Pourfar said. "The number of subjects in the study was relatively small and prior PET studies have not consistently demonstrated the same findings, so many questions remain about the nature of the association between manganese and parkinsonism," he added.

The study appears online April 6 in the journal Neurology.

More information

We Move has more about Parkinson's disease.

-- Robert Preidt

SOURCE: Michael Pourfar, MD, director, Division of Movement Disorders, North Shore-LIJ Health System, Great Neck, NY; Neurology, news release, April 6, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Refusal skills help minority youths combat smoking, study finds
2. Children relate to stepparents based on perceived financial, emotional benefits, study finds
3. New drug shrinks cancer in animals, U-M study shows
4. An international study in China finds strawberries may slow precancerous growth in the esophagus
5. Study: Socioeconomics playing reduced role in autism diagnoses
6. Babies Born to Obese Moms Face Higher Death Risk: Study
7. Elevated levels of sodium blunt response to stress, study shows
8. NIH, USU study maps hotspots of genetic rearrangement
9. Soy Foods OK After Breast Cancer: Study
10. Grant helps UT Southwestern researcher study causes of preterm birth
11. Penn study sheds light on end of life management of implanted defibrillators
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study Probes Potential Link Between Welding, Parkinson's Disease
(Date:10/13/2017)... ... October 13, 2017 , ... Lori R. Somekh, founder of the Law ... organization of elder law and special needs planning attorneys. “Membership in ElderCounsel helps our ... a forum to network with elder law attorneys nationwide,” said Somekh. , ...
(Date:10/13/2017)... ... ... Global Healthcare Management’s 4th Annual Kids Fun Run brought out many kids ... sponsored by Global Healthcare Management’s CEO, Jon Letko, is aimed at getting kids excited ... all ages; it is a non-competitive, non-timed event, which is all about having fun ...
(Date:10/13/2017)... ... 2017 , ... “America On The Brink”: the Christian history of the United ... the creation of published author, William Nowers. Captain Nowers and his wife, Millie, ... spent thirty years in the Navy. Following his career as a naval aviator ...
(Date:10/12/2017)... ... 2017 , ... IsoComforter, Inc. ( https://isocomforter.com ), one of the ... new design of the shoulder pad. The shoulder pad provides optimal support and ... pain while using cold therapy. By utilizing ice and water that is circulated from ...
(Date:10/12/2017)... ... October 12, 2017 , ... HMP , a leader in healthcare events ... Magazine Eddie Digital Award for ‘Best B-to-B Healthcare Website.’ Winners were announced during the ... The annual award competition recognizes editorial and design excellence across a range of sectors. ...
Breaking Medicine News(10 mins):
(Date:9/27/2017)... Sept. 27, 2017  Commended for their devotion to personalized ... Ranked as number one in the South Florida Business Journal,s ... Inc. 5000 yearly list, the national specialty pharmacy has found ... Bardisa will soon be honored by SFBJ as the ... Set to receive his award in October, Bardisa ...
(Date:9/25/2017)...   Montrium , an industry leader in ... IQPC Trial Master Files & Inspection Readiness Conference ... Clinical Services has selected eTMF Connect ... EastHORN, a leading European contract research organization (CRO), ... to enable greater collaboration with sponsors, improve compliance ...
(Date:9/23/2017)... , Sept. 22, 2017 Janssen Biotech, ... complete response letter from the U.S. Food and Drug ... approval of sirukumab for the treatment of moderately to ... indicates additional clinical data are needed to further evaluate ... to severely active RA. ...
Breaking Medicine Technology: